Case Study: Armenian and Cuban Ethnic Interest Groups in American Foreign Policy

Current academic research has moved away from comparative models as a mechanism by which to assess and understand socio-political as well as historical phenomena. In addition, comparative analysis when it comes to addressing ethnic lobbies is almost nonexistent within contemporary research. This work implements a comparative framework and as a result has unlocked a new approach when addressing ethnic advocacy organizations. The purpose of this research is to assess and document the history and impact of both Armenian and Cuban ethnic interest groups within the United States. Specifically, focusing upon the Armenian National Committee of America and the Cuban American National Foundation. The work centers upon two case studies that embody the relative successes and achievements of both institutions. The first being Section 907 of the Freedom and Support Act of 1992 that banned direct US aid to the Republic of Azerbaijan. The second case study is the passage of The Radio Broadcasting To Cuba Act of 1983 that resulted in what became known as Radio Marti. This work attempts to illustrate the degree to which these Armenian and Cuban ethnic interest groups influenced legislation and by so doing, legitimized their status within their ethnic communities. The passage of these foreign policy initiatives portrayed these diasporan advocacy groups as crucial to the long-term viability of their communities. The comparative model used within this work illustrates that the ethnic interest groups listed above shaped and altered their host nation; the processes they utilized can best be described by four key factors. The relative success and long-term viability of both the legislative acts and the ethnic organizations themselves would be driven by the realization and attainment of these four factors. The comparative model provides a platform by which these four factors are realized, allowing for a broader context by which to understand the impact ethnic interest groups have on US foreign policy development. The corresponding success of these two ethnic interest groups can be directly associated with their ability to advance within as well as successfully employ these four factors

Enabling a High Throughput Real Time Data Pipeline for a Large Radio Telescope Array with GPUs

The Murchison Widefield Array (MWA) is a next-generation radio telescope currently under construction in the remote Western Australia Outback. Raw data will be generated continuously at 5GiB/s, grouped into 8s cadences. This high throughput motivates the development of on-site, real time processing and reduction in preference to archiving, transport and off-line processing. Each batch of 8s data must be completely reduced before the next batch arrives. Maintaining real time operation will require a sustained performance of around 2.5TFLOP/s (including convolutions, FFTs, interpolations and matrix multiplications). We describe a scalable heterogeneous computing pipeline implementation, exploiting both the high computing density and FLOP-per-Watt ratio of modern GPUs. The architecture is highly parallel within and across nodes, with all major processing elements performed by GPUs. Necessary scatter-gather operations along the pipeline are loosely synchronized between the nodes hosting the GPUs. The MWA will be a frontier scientific instrument and a pathfinder for planned peta- and exascale facilities.Comment: Version accepted by Comp. Phys. Com

HST Measurements of the Expansion of NGC 6543: Parallax Distance and Nebular Evolution

The optical expansion parallax of NGC 6543 has been detected and measured using two epochs of HST images separated by a time baseline of only three years. We have utilized three separate methods of deriving the angular expansion of bright fiducials, the results of which are in excellent agreement. We combine our angular expansion estimates with spectroscopically obtained expansion velocities to derive a distance to NGC 6543 of 1001$\pm$269 pc. The deduced kinematic age of the inner bright core of the nebula is 1039$\pm$259 years; however, the kinematic age of the polar caps that surround the core is larger - perhaps the result of deceleration or earlier mass ejection. The morphology and expansion patterns of NGC 6543 provide insight into a complex history of axisymmetric, interacting stellar mass ejections.Comment: Accepted for publication in AJ. 18 pages. 6 figure

Hubble-type outflows of the high-excitation, poly-polar planetary nebula NGC 6302 -- from expansion proper motions

The ouflowing proper motions of fifteen knots in the dominant northwestern lobe of the high-excitation poly-polar planetary nebula NGC 6302 have been determined by comparing their positions relative to those of faint stars in an image taken at the San Pedro Martir Observatory in 2007 to those in a South African Astronomical Observatory archival plate obtained by Evans in 1956. The Hubble-type expansion of this lobe is now directly confirmed in a model independent way from these measurements. Furthermore, an unambiguous distance to NGC 6302 of 1.17 +/- 0.14 kpc is now determined. Also all the velocity vectors of the fifteen knots (and two others) point back to the central source. An eruptive event from within the central torus, approximately 2200 years previously must have created the high speed lobes of NGC 6302.Comment: 12 pages, 5 figures, MNRAS in pres

A search for periodicity in the light curves of selected blazars

We present an analysis of multifrequency light curves of the sources 2223-052 (3C 446), 2230+114 (CTA 102), and 2251+158 (3C 454.3), which had shown evidence of quasi-periodic activity. The analysis made use of data from the University of Michican Radio Astronomy Observatory (USA) at 4.8, 8, and 14.5 GHz, as well as the Metsahovi Radio Astronomy Observatory (Finland) at 22 and 37 GHz. Application of two different methods (the discrete autocorrelation function and the method of Jurkevich) both revealed evidence for periodicity in the flux variations of these sources at essentially all frequencies. The periods derived for at least two of the sources -- 2223-052 and 2251+158-- are in good agreement with the time interval between the appearance of successive VLBI components. The derived periods for 2251+158 (P = 12.4 yr and 2223-052 (P = 5.8 yr) coincide with the periods found earlier by other authors based on optical light curves.Comment: 27 pages, 11 figures, accepted for publication in Astronomy Report

Hubble Space Telescope Expansion Parallaxes of the Planetary Nebulae NGC 6578, NGC 6884, NGC 6891, and IC 2448

We have combined two epochs of Hubble Space Telescope WFPC2 imaging data with ground-based expansion velocities to determine distances to three planetary nebulae (NGC 6578, NGC 6884, and IC 2448). We used two variants of the expansion parallax technique--a gradient method and a magnification method--to determine the distances. The results from the two methods agree to within the errors. A fourth nebula was included in the study (NGC 6891), but the expansion was too small to determine the distance, and only a lower limit was obtained. This is the first paper in a series which will examine at least 24 nebulae in total.Comment: 26 pages, 6 figures, figure 2 is color. accepted AJ, March 200

The extraordinary evolutionary history of the reticuloendotheliosis viruses

The reticuloendotheliosis viruses (REVs) comprise several closely related amphotropic retroviruses isolated from birds. These viruses exhibit several highly unusual characteristics that have not so far been adequately explained, including their extremely close relationship to mammalian retroviruses, and their presence as endogenous sequences within the genomes of certain large DNA viruses. We present evidence for an iatrogenic origin of REVs that accounts for these phenomena. Firstly, we identify endogenous retroviral fossils in mammalian genomes that share a unique recombinant structure with REVs—unequivocally demonstrating that REVs derive directly from mammalian retroviruses. Secondly, through sequencing of archived REV isolates, we confirm that contaminated Plasmodium lophurae stocks have been the source of multiple REV outbreaks in experimentally infected birds. Finally, we show that both phylogenetic and historical evidence support a scenario wherein REVs originated as mammalian retroviruses that were accidentally introduced into avian hosts in the late 1930s, during experimental studies of P. lophurae, and subsequently integrated into the fowlpox virus (FWPV) and gallid herpesvirus type 2 (GHV-2) genomes, generating recombinant DNA viruses that now circulate in wild birds and poultry. Our findings provide a novel perspective on the origin and evolution of REV, and indicate that horizontal gene transfer between virus families can expand the impact of iatrogenic transmission events

Novel Use of Surveillance Data to Detect HIV-Infected Persons with Sustained High Viral Load and Durable Virologic Suppression in New York City

Background: Monitoring of the uptake and efficacy of ART in a population often relies on cross-sectional data, providing limited information that could be used to design specific targeted intervention programs. Using repeated measures of viral load (VL) surveillance data, we aimed to estimate and characterize the proportion of persons living with HIV/AIDS (PLWHA) in New York City (NYC) with sustained high VL (SHVL) and durably suppressed VL (DSVL). Methods/Principal Findings: Retrospective cohort study of all persons reported to the NYC HIV Surveillance Registry who were alive and $12 years old by the end of 2005 and who had$2 VL tests in 2006 and 2007. SHVL and DSVL were defined as PLWHA with 2 consecutive VLs $100,000 copies/mL and PLWHA with all VLs #400 copies/mL, respectively. Logistic regression models using generalized estimating equations were used to model the association between SHVL and covariates. There were 56,836 PLWHA, of whom 7 % had SHVL and 38 % had DSVL. Compared to those without SHVL, persons with SHVL were more likely to be younger, black and have injection drug use (IDU) risk. PLWHA with SHVL were more likely to die by 2007 and be younger by nearly ten years, on average. Conclusions/Significance: Nearly 60 % of PLWHA in 2005 had multiple VLs, of whom almost 40 % had DSVL, suggesting successful ART uptake. A small proportion had SHVL, representing groups known to have suboptimal engagement in care. This group should be targeted for additional outreach to reduce morbidity and secondary transmission. Measures based o

Intermediate and extreme mass-ratio inspirals — astrophysics, science applications and detection using LISA

Black hole binaries with extreme (gtrsim104:1) or intermediate (~102–104:1) mass ratios are among the most interesting gravitational wave sources that are expected to be detected by the proposed laser interferometer space antenna (LISA). These sources have the potential to tell us much about astrophysics, but are also of unique importance for testing aspects of the general theory of relativity in the strong field regime. Here we discuss these sources from the perspectives of astrophysics, data analysis and applications to testing general relativity, providing both a description of the current state of knowledge and an outline of some of the outstanding questions that still need to be addressed. This review grew out of discussions at a workshop in September 2006 hosted by the Albert Einstein Institute in Golm, Germany

DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway

Stabilization of mutant p53 (mutp53) in tumours greatly contributes to malignant progression. However, little is known about the underlying mechanisms and therapeutic approaches to destabilize mutp53. Here, through high-throughput screening we identify statins, cholesterol-lowering drugs, as degradation inducers for conformational or misfolded p53 mutants with minimal effects on wild-type p53 (wtp53) and DNA contact mutants. Statins preferentially suppress mutp53-expressing cancer cell growth. Specific reduction of mevalonate-5-phosphate by statins or mevalonate kinase knockdown induces CHIP ubiquitin ligase-mediated nuclear export, ubiquitylation, and degradation of mutp53 by impairing interaction of mutp53 with DNAJA1, a Hsp40 family member. Knockdown of DNAJA1 also induces CHIP-mediated mutp53 degradation, while its overexpression antagonizes statin-induced mutp53 degradation. Our study reveals that DNAJA1 controls the fate of misfolded mutp53, provides insights into potential strategies to deplete mutp53 through the mevalonate pathway–DNAJA1 axis, and highlights the significance of p53 status in impacting statins’ efficacy on cancer therapy