The Specific Feature in the Development of Modem Japanese Monogamy

福島四郎教授還暦記念特

The Social Condition of the Monogamy

伊沢孝平教授還暦記念特

The Character of Japanese Succession Law

創立八十周年記念特

The comparison of endothelial function between conduit artery and microvasculature in patients with coronary artery disease

Background: Flow-mediated dilation (FMD) and reactive hyperemia-peripheral arterial tonometry (RH-PAT) are both established modalities to assess vascular endothelial function. However, clinical significance of FMD and RH-PAT may be different because these methods measure vascular function in different vessels (conduit arteries and resistance vessels). Methods: To elucidate differences in the clinical significance of FMD and RH-PAT, a simultaneous determination of FMD was performed and reactive hyperemia index (RHI) measured by RH-PAT in 131 consecutive patients who underwent coronary angiography for suspicion of coronary artery disease (CAD). Results: There was no significant correlation between FMD and RHI in patients overall. When patients were divided into four groups: FMD ≥ 6%/RHI ≥ 1.67 group, FMD ≥ 6%/RHI < 1.67 group, FMD < 6%/RHI ≥ 1.67 group and FMD < 6%/RHI < 1.67 group, the highest incidence of multivessel CAD was seen in the FMD < 6%/RHI < 1.67 group (52%). Multiple logistic regression analysis showed that a prevalence of both FMD < 6% and RHI < 1.67 was an independent predictor of multivessel CAD (odds ratio: 4.160, 95% confidence interval: 1.505–11.500, p = 0.006). RHI was negatively correlated with the baseline vessel diameter (R = –0.268, p = 0.0065) and maximum vessel diameter (R = –0.266, p = 0.0069) in patients with FMD < 6%, whereas these correlations were absent in patients with FMD ≥ 6%. Conclusions: Present results suggest that noninvasive assessment of vascular endothelial functions provide pathophysiological information on both conduit arteries and resistance vessels in patients with CAD

Sensing of Oxygen Concentration in a Microfluidic Device mimicking Liver 3D Microarchitecture

International audienceWe designed a microfluidic structure which closely reproduces liver microarchitecture, constraining primary rat hepatocytes at a high density and in three dimensions (3D), and in which a gradient of oxygen can be generated. The device includes an oxygen sensitive membrane that could map the oxygen consumption of hepatocytes. INTRODUCTION Compared to classical two-dimensional cell culture, microfluidic devices or/and 3D culture conditions were evidenced to increase the period of time during which primary hepatocytes retain their functions [1]. Moreover, microfluidic techniques offer the opportunity to mimic the in vivo hepatocyte zonation, by subjecting hepatocytes to oxygen gradients [1-2]. Such oxygen gradients that can be estimated by numerical simulations, were recently experimentally assessed using an oxygen sensitive fluorescent membrane [3]. We proposed to include the oxygen sensitive membrane within a miniaturized fluidic device mimicking several hepatic cords in series, and inducing a gradient of oxygen on those. Moreover each of those hepatic cord units was inducing 3D organization of hepatocytes, due to the 72 µm height of culture chambers in which they can aggregate

Result from surgical treatment on the terrible triad of the elbow

AbstractObjectiveTo evaluate the results from surgical treatment of the terrible triad of the elbow, with a minimum of six months of follow-up, taking elbow function into consideration.MethodsThe analyzed aspects of 20 patients, who underwent surgical treatment of the terrible triad of the elbow, were given as follows: Dash score (Disabilities of the Arm, Shoulder and Hand), Meps (Mayo Elbow Performance Score), pain according to VAS (visual analog scale), ROM (range of motion), patient satisfaction, degree of energy of the trauma, complications and radiographs.ResultsThe mean length of follow-up among the patients was 38 months. There were statistically significant relationships between the following set of parameters: trauma mechanism and patient satisfaction; radiological outcome of “heterotopic ossification” and satisfaction; functional flexion–extension ROM and satisfaction; and between type of radial head fracture and presence of a radiological outcome.ConclusionThe surgical treatment for the terrible triad of the elbow generally provided satisfactory results, when the functioning of this joint upon the return to activities was taken into consideration