R０LE OF α1-ADRENERGIC RECEPTORS AND THE EFFECT OF BUNAZOSIN ON THE HISTOPATHOLOGY OF CARDIOMYOPATHIC SYRIAN HAMSTERS OF STRAIN BIO 14.6

In order to clarify the pathological involvement of the sympathetic nervous system in the development of cardiomyopathy, a receptor-binding study was carried out on cardiomyopathic Syrian hamsters of strain BIO 14.6 (BIO) at 21 days (prenecrotic stage); 35-42 days (onset of cardiomyopathy); and 70-84 days of life (early cardiac hypertrophy). The newly developed α_1-blocker (bunazosin hydrochloride) was initially administered at doses of 100 μg/kg or 10 mg/kg BIO hamsters at 21 days of life and continued for 70 days. At the onset of cardiomyopathy and early cardiac hypertrophy, there was an increase in the number of α_1-receptors in the BIO hamsters compared to controls, but there were no significant changes at the prenecrotic stage. On histopathological examination, 10 mg/kg bunazosin had a singnificant beneficial effect on cardiomyopathy [area of necrosis 1.38% in untreated vs 0.33% in treated animals; area of calcification 2.70% (untreated) vs 0.60% (treated); area of all myocardial injuries 6.97% (untreated) vs 3.19% (treated)]. However, 100 μg/kg bunazosin had no effect. It was concluded that the increase in the number of α_1-receptors may not be involved in the pathogenesis of cardiomyopathy but that α_1-receptors could be implicated in the later progression of the condition.浜松医科大学学位論文　医博第91号(平成02年03月26日）rights:社団法人日本循環器学会rights:本文データは学協会の許諾に基づきCiNiiから複製したものであ