CADUCEUS, SCIPIO, ALCADIA: Cell therapy trials using cardiac-derived cells for patients with post myocardial infarction LV dysfunction, still evolving.

The early results of the CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction study were recently published in the Lancet [1]. This study is a phase 1 prospective randomised study, performed at two centres. The study was designed to test the hypothesis that intracoronary infusion of autologous cardiac-derived cells following myocardial infarction can reduce the size of the infarct and increase the amount of viable myocardium. The eligible patients were randomised in a 2:1 ratio to receive CDCs or standard care. In all, 17 patients were randomised to cell therapy and 8 to standard care. The cell therapy consisted of an infusion of 25 million cells into the infarct related artery, 1.5–3 months after successful primary angioplasty in patients who developed LV dysfunction (EF less than 37 per cent). The cells were derived from RV endomyocardial biopsies performed within the previous 37 days. The number of cells was determined from previous experimental studies of the maximum number of cells which can be injected without inducing infarction. The study was not blinded because of ethical considerations regarding performing right ventricular biopsy on the controls. The exclusion criteria included patients who had evidence of right ventricular infarction, or could not have an MRI examination because of claustrophobia or prior insertion of devices. There was no death, myocardial infarction or serious arrhythmia reported in either group during the period of follow up, which was between 6-12 months. Serious adverse events were observed in 24 percent of the intervention group versus 12 per cent in the controls (p not significant)

Privacy Preservation by Disassociation

In this work, we focus on protection against identity disclosure in the publication of sparse multidimensional data. Existing multidimensional anonymization techniquesa) protect the privacy of users either by altering the set of quasi-identifiers of the original data (e.g., by generalization or suppression) or by adding noise (e.g., using differential privacy) and/or (b) assume a clear distinction between sensitive and non-sensitive information and sever the possible linkage. In many real world applications the above techniques are not applicable. For instance, consider web search query logs. Suppressing or generalizing anonymization methods would remove the most valuable information in the dataset: the original query terms. Additionally, web search query logs contain millions of query terms which cannot be categorized as sensitive or non-sensitive since a term may be sensitive for a user and non-sensitive for another. Motivated by this observation, we propose an anonymization technique termed disassociation that preserves the original terms but hides the fact that two or more different terms appear in the same record. We protect the users' privacy by disassociating record terms that participate in identifying combinations. This way the adversary cannot associate with high probability a record with a rare combination of terms. To the best of our knowledge, our proposal is the first to employ such a technique to provide protection against identity disclosure. We propose an anonymization algorithm based on our approach and evaluate its performance on real and synthetic datasets, comparing it against other state-of-the-art methods based on generalization and differential privacy.Comment: VLDB201

Local and global recoding methods for anonymizing set-valued data

In this paper, we study the problem of protecting privacy in the publication of set-valued data. Consider a collection of supermarket transactions that contains detailed information about items bought together by individuals. Even after removing all personal characteristics of the buyer, which can serve as links to his identity, the publication of such data is still subject to privacy attacks from adversaries who have partial knowledge about the set. Unlike most previous works, we do not distinguish data as sensitive and non-sensitive, but we consider them both as potential quasi-identifiers and potential sensitive data, depending on the knowledge of the adversary. We define a new version of the k-anonymity guarantee, the k m-anonymity, to limit the effects of the data dimensionality, and we propose efficient algorithms to transform the database. Our anonymization model relies on generalization instead of suppression, which is the most common practice in related works on such data. We develop an algorithm that finds the optimal solution, however, at a high cost that makes it inapplicable for large, realistic problems. Then, we propose a greedy heuristic, which performs generalizations in an Apriori, level-wise fashion. The heuristic scales much better and in most of the cases finds a solution close to the optimal. Finally, we investigate the application of techniques that partition the database and perform anonymization locally, aiming at the reduction of the memory consumption and further scalability. A thorough experimental evaluation with real datasets shows that a vertical partitioning approach achieves excellent results in practice. © 2010 Springer-Verlag.postprin

Local Suppression and Splitting Techniques for Privacy Preserving Publication of Trajectories

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Parallel In-Memory Evaluation of Spatial Joins

The spatial join is a popular operation in spatial database systems and its evaluation is a well-studied problem. As main memories become bigger and faster and commodity hardware supports parallel processing, there is a need to revamp classic join algorithms which have been designed for I/O-bound processing. In view of this, we study the in-memory and parallel evaluation of spatial joins, by re-designing a classic partitioning-based algorithm to consider alternative approaches for space partitioning. Our study shows that, compared to a straightforward implementation of the algorithm, our tuning can improve performance significantly. We also show how to select appropriate partitioning parameters based on data statistics, in order to tune the algorithm for the given join inputs. Our parallel implementation scales gracefully with the number of threads reducing the cost of the join to at most one second even for join inputs with tens of millions of rectangles.Comment: Extended version of the SIGSPATIAL'19 paper under the same titl

Two-layer Space-oriented Partitioning for Non-point Data

Non-point spatial objects (e.g., polygons, linestrings, etc.) are ubiquitous. We study the problem of indexing non-point objects in memory for range queries and spatial intersection joins. We propose a secondary partitioning technique for space-oriented partitioning indices (e.g., grids), which improves their performance significantly, by avoiding the generation and elimination of duplicate results. Our approach is easy to implement and can be used by any space-partitioning index to significantly reduce the cost of range queries and intersection joins. In addition, the secondary partitions can be processed independently, which makes our method appropriate for distributed and parallel indexing. Experiments on real datasets confirm the advantage of our approach against alternative duplicate elimination techniques and data-oriented state-of-the-art spatial indices. We also show that our partitioning technique, paired with optimized partition-to-partition join algorithms, typically reduces the cost of spatial joins by around 50%.Comment: To appear in the IEEE Transactions on Knowledge and Data Engineerin