Carcinogenicity of a Single Administration of N-Nitrosomethylurea: a Comparison Between New-born and 5-Week-Old Mice and Rats

N-Nitrosomethylurea (NMUrea) was given as a single intraperitoneal injection either to newborn or to 5-week-old (C57BL * C3Hf)F1 mice and Wistar rats. Newborn mice were more susceptible than 5-week-old mice to the development of lymphosarcomas, lung adenomas and hepatomas, whereas newborn rats were more susceptible than their weaned counterparts to the development of renal anaplastic tumours. Other tumours occured with the same frequency in newborn and mature animals. Tumours of the forestomach in mice were more frequenty found in animals treated at 5 weeks than in those treated at birth. Since NMUrea persists for only a very short time and breaks down spontaneously it seems that the paucity of enzymes related to immaturity in newborns is not a major factor in determining the different susceptibility of newborn animals to NMUrea carcinogenicity

Regularity of the optimal sets for some spectral functionals

In this paper we study the regularity of the optimal sets for the shape optimization problem min{λ1(Ω)+⋯+λk(Ω) : Ω⊂Rd open, |Ω|=1}, where λ1(·) , … , λk(·) denote the eigenvalues of the Dirichlet Laplacian and | · | the d-dimensional Lebesgue measure. We prove that the topological boundary of a minimizer Ωk∗ is composed of a relatively open regular part which is locally a graph of a C∞ function and a closed singular part, which is empty if d< d∗, contains at most a finite number of isolated points if d= d∗ and has Hausdorff dimension smaller than (d- d∗) if d> d∗, where the natural number d∗∈ [ 5 , 7 ] is the smallest dimension at which minimizing one-phase free boundaries admit singularities. To achieve our goal, as an auxiliary result, we shall extend for the first time the known regularity theory for the one-phase free boundary problem to the vector-valued case

Increased risk of malignant mesothelioma of the pleura after residential or domestic exposure to asbestos: a case-control study in Casale Monferrato, Italy.

The association of malignant mesothelioma (MM) and nonoccupational asbestos exposure is currently debated. Our study investigates environmental and domestic asbestos exposure in the city where the largest Italian asbestos cement (AC) factory was located. This population-based case-control study included pleural MM (histologically diagnosed) incidents in the area in 1987-1993, matched by age and sex to two controls (four if younger than 60). Diagnoses were confirmed by a panel of five pathologists. We interviewed 102 cases and 273 controls in 1993-1995, out of 116 and 330 eligible subjects. Information was checked and completed on the basis of factory and Town Office files. We adjusted analyses for occupational exposure in the AC industry. In the town there were no other relevant industrial sources of asbestos exposure. Twenty-three cases and 20 controls lived with an AC worker [odds ratio (OR) = 4.5; 95% confidence interval (CI), 1.8-11.1)]. The risk was higher for the offspring of AC workers (OR = 7.4; 95% CI, 1.9-28.1). Subjects attending grammar school in Casale also showed an increased risk (OR = 3.3; 95% CI, 1.4-7.7). Living in Casale was associated with a very high risk (after selecting out AC workers: OR = 20.6; 95% CI, 6.2-68.6), with spatial trend with increasing distance from the AC factory. The present work confirms the association of environmental asbestos exposure and pleural MM, controlling for other sources of asbestos exposure, and suggests that environmental exposure caused a greater risk than domestic exposure

Multipulse phases in k-mixtures of Bose-Einstein condensates

For a competitive system of k coupled nonlinear Schroedinger equations we prove the existence, when the competition parameter is large, of positive radial solutions on R^N. We show that, when the competition parameter goes to infinity, the profile of each component separates, in many pulses, from the others. Moreover, we can prescribe the location of such pulses in terms of the oscillations of the changing-sign solutions of the scalar nonlinear Schroedinger equation. Within an Hartree-Fock approximation, this provides a theoretical indication of phase separation into many nodal domains for the k-mixtures of Bose-Einstein condensates.Comment: 21 page

Multicentric study on malignant pleural mesothelioma and non-occupational exposure to asbestos

Insufficient evidence exists on the risk of pleural mesothelioma from non-occupational exposure to asbestos. A population-based case–control study was carried out in six areas from Italy, Spain and Switzerland. Information was collected for 215 new histologically confirmed cases and 448 controls. A panel of industrial hygienists assessed asbestos exposure separately for occupational, domestic and environmental sources. Classification of domestic and environmental exposure was based on a complete residential history, presence and use of asbestos at home, asbestos industrial activities in the surrounding area, and their distance from the dwelling. In 53 cases and 232 controls without evidence of occupational exposure to asbestos, moderate or high probability of domestic exposure was associated with an increased risk adjusted by age and sex: odds ratio (OR) 4.81, 95% confidence interval (CI) 1.8–13.1. This corresponds to three situations: cleaning asbestos-contaminated clothes, handling asbestos material and presence of asbestos material susceptible to damage. The estimated OR for high probability of environmental exposure (living within 2000 m of asbestos mines, asbestos cement plants, asbestos textiles, shipyards, or brakes factories) was 11.5 (95% CI 3.5–38.2). Living between 2000 and 5000 m from asbestos industries or within 500 m of industries using asbestos could also be associated with an increased risk. A dose–response pattern appeared with intensity of both sources of exposure. It is suggested that low-dose exposure to asbestos at home or in the general environment carries a measurable risk of malignant pleural mesothelioma. © 2000 Cancer Research Campaig