1 research outputs found
Synthesis and Functionalization of Tertiary Propargylic Boronic Esters by Alkynyllithium-Mediated 1,2-Metalate Rearrangement of Borylated Cyclopropanes
Implementing
the use of alkynyllithium reagents in a stereospecific
1,2-metalate rearrangement-mediated ring opening of polysubstituted
cyclopropyl boronic esters provides a variety of tertiary pinacol
boranes bearing adjacent tertiary or quaternary carbon stereocenters
with high levels of diastereomeric purity. The potential of this strategy
was demonstrated through a selection of α- and γ-functionalization
of the propargyl boronic esters