The God particle: if the universe is the answer, what is the question ?

In this extraordinarily accessible and enormously witty book, the Nobel Prize-winning physicist Leon Lederman guides us on a fascinating tour of the history of particle physics. The book takes us from the Greeks' earliest scientific observations through Einstein and beyond in an inspiring celebration of human curiosity. It ends with the quest for the Higgs boson, nicknamed the God Particle, which scientists hypothesize will help unlock the last secrets of the subatomic universe. With a new preface by Lederman, The God Particle will leave you marveling at our continuing pursuit of the infinitesIn this extraordinarily accessible and enormously witty book, the Nobel Prize-winning physicist Leon Lederman guides us on a fascinating tour of the history of particle physics. The book takes us from the Greeks' earliest scientific observations through Einstein and beyond in an inspiring celebration of human curiosity. It ends with the quest for the Higgs boson, nicknamed the God Particle, which scientists hypothesize will help unlock the last secrets of the subatomic universe. With a new preface by Lederman, The God Particle will leave you marveling at our continuing pursuit of the infinitesimal

Concurrent Validity and Reliability of Suicide Risk Assessment Instruments: A Meta-Analysis of 20 Instruments Across 27 International Cohorts

Objective: A major limitation of current suicide research is the lack of power to identify robust correlates of suicidal thoughts or behavior. Variation in suicide risk assessment instruments used across cohorts may represent a limitation to pooling data in international consortia. Method: Here, we examine this issue through two approaches: (a) an extensive literature search on the reliability and concurrent validity of the most commonly used instruments and (b) by pooling data (N ∼ 6,000 participants) from cohorts from the Enhancing NeuroImaging Genetics Through Meta-Analysis (ENIGMA) Major Depressive Disorder and ENIGMA–Suicidal Thoughts and Behaviour working groups, to assess the concurrent validity of instruments currently used for assessing suicidal thoughts or behavior. Results: We observed moderate-to-high correlations between measures, consistent with the wide range (κ range: 0.15–0.97; r range: 0.21–0.94) reported in the literature. Two common multi-item instruments, the Columbia Suicide Severity Rating Scale and the Beck Scale for Suicidal Ideation were highly correlated with each other (r = 0.83). Sensitivity analyses identified sources of heterogeneity such as the time frame of the instrument and whether it relies on self-report or a clinical interview. Finally, construct-specific analyses suggest that suicide ideation items from common psychiatric questionnaires are most concordant with the suicide ideation construct of multi-item instruments. Conclusions: Our findings suggest that multi-item instruments provide valuable information on different aspects of suicidal thoughts or behavior but share a modest core factor with single suicidal ideation items. Retrospective, multisite collaborations including distinct instruments should be feasible provided they harmonize across instruments or focus on specific constructs of suicidality