Adjusted likelihood of death from hemorrhagic and ischemic stroke in HIV/HCV-coinfected patients compared with HIV-monoinfected patients in Spain (1997–2013).

<p>Abbreviations: HCV, hepatitis C virus; HIV, human immunodeficiency virus; aOR, adjusted odds ratio; 95%CI, 95% confidence interval.</p

Incidence rates of hospitalization for hemorrhagic stroke (Fig 1A) and for ischemic stroke (Fig 1B) in the four study periods.

<p>P-values: (*), differences between HIV-monoinfected patients and HIV/HCV-coinfected patients by the exact confidence intervals for incidence; (§), linear trend from 1997–1999 to 2008–2013 in HIV-monoinfected patients by the Extended Mantel-Haenszel chi-square; (†), linear trend from 1997–1999 to 2008–2013 in HIV-infected patients by the Extended Mantel-Haenszel chi-square; (‡), linear trend from 1997–1999 to 2008–2013 in HIV/HCV-coinfected patients by the Extended Mantel-Haenszel chi-square. The numbers at the base of the panels are the total numbers of hospitalizations in each calendar period and study group. Abbreviations: HCV, hepatitis C virus; HIV, human immunodeficiency virus; p-yr, patient-years.</p

Epidemiological and clinical characteristics of HIV-infected patients with a hospital admission and diagnosis of stroke from 1997 to 2013 in Spain.

<p>Epidemiological and clinical characteristics of HIV-infected patients with a hospital admission and diagnosis of stroke from 1997 to 2013 in Spain.</p

Case fatality rates for hemorrhagic stroke (Fig 2A) and for ischemic stroke (Fig 2B) in the four study periods stratified by HCV status.

<p>P-values: (*), differences between HIV-monoinfected patients and HIV/HCV-coinfected patients by the exact confidence intervals for incidence; (§), linear trend from 1997–1999 to 2008–2013 in HIV-monoinfected patients by the Extended Mantel-Haenszel chi-square; (†), linear trend from 1997–1999 to 2008–2013 in HIV-infected patients by the Extended Mantel-Haenszel chi-square; (‡), linear trend from 1997–1999 to 2008–2013 in HIV/HCV-coinfected patients by the Extended Mantel-Haenszel chi-square. The numbers at the base of the panels are the total numbers of deaths in each calendar period and study group. Abbreviations: HCV, hepatitis C virus; HIV, human immunodeficiency virus.</p

Accuracy of sICAM-1 and sVCAM-1 serum levels for the prediction of liver-related events.

<p>The <i>P</i> value refers to the comparison of ROC curves according to the method of Hanley and McNeil. Abbreviations: AUROC, area under the receiver operating characteristic curves.</p

Hazard of events for sICAM-1 and sVCAM-1 serum levels higher the optimized cutoff values^*.

<p>Hazard of events for sICAM-1 and sVCAM-1 serum levels higher the optimized cutoff values^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0148537#t002fn001" target="_blank">*</a>}.</p

Characteristics of 182 HIV/HCV coinfected patients who had both a liver biopsy and simultaneous frozen plasma samples taken between 2000 and 2007.

<p>Characteristics of 182 HIV/HCV coinfected patients who had both a liver biopsy and simultaneous frozen plasma samples taken between 2000 and 2007.</p