Urinary Bisphenol A and Hypertension in a Multiethnic Sample of US Adults

Background. Bisphenol A (BPA) is a common chemical used in the manufacture of polycarbonate plastics and epoxy resins, with >93% of US adults having detectable BPA levels in urine. Recent animal studies have suggested that BPA exposure may have a role in several mechanisms involved in the development of hypertension, including weight gain, insulin resistance, thyroid dysfunction, endothelial dysfunction, and oxidative stress. However, no previous human study has examined the association between markers of BPA exposure and hypertension. Methods. We examined urinary BPA levels in 1380 subjects from the National Health and Nutritional Examination Survey 2003-2004. Main outcome-of-interest was hypertension, defined as blood pressure-reducing medication use and/or blood pressures >140/90 mm of Hg (n = 580). Results. We observed a positive association between increasing levels of urinary BPA and hypertension independent of confounding factors such as age, gender, race/ethnicity, smoking, body mass index (BMI), diabetes mellitus and total serum cholesterol levels. Compared to tertile 1 (referent), the multivariate-adjusted odds ratio (95% confidence interval) of hypertension associated with tertile 3 was 1.50 (1.12−2.00); P-trend = 0.007. The association was consistently present in subgroup analyses by race/ethnicity, smoking status, BMI, and diabetes mellitus. Conclusions. Urinary BPA levels are associated with hypertension, independent of traditional risk factors

Markers of Sleep Disordered Breathing and Diabetes Mellitus in a Multiethnic Sample of US Adults: Results from the National Health and Nutrition Examination Survey (2005–2008)

We examined gender and ethnic differences in the association between sleep disordered breathing (SDB) and diabetes among 6,522 participants aged ≥20 years from the National Health and Nutrition Examination Survey 2005–08. SDB severity was defined based on an additive summary score including sleep duration, snoring, snorting, and daytime sleepiness. We found that the summary SDB score was significantly associated with diabetes after adjusting for potential confounders in the whole population. Compared to those without any sleep disturbance, the multivariable odds ratio (OR) (95% confidence interval (CI)) of diabetes among those with ≥3 sleep disturbances was 2.04 (1.46–2.87). In sex-specific analyses, this association was significant only in women (OR (95% CI) = 3.68 (2.01–6.72)) but not in men (1.10 (0.59–2.04)), P-interaction = 0.01. However, there were no ethnic differences in this association, P-interaction = 0.7. In a nationally representative sample of US adults, SDB was independently associated with diabetes only in women, but not in men

Bisphenol A and Metabolic Syndrome: Results from NHANES

Background. Bisphenol A (BPA) is detected in the urine of 95% of US adults. Recent evidence from population-based studies suggests that BPA is associated with individual components for metabolic syndrome (MetS). However, no previous study has examined the direct association between BPA and MetS. Methods. We examined 2,104 participants from the National Health and Nutrition Examination Survey 2003–2008. The main outcome was the presence of MetS (). Results. Increasing levels of urinary BPA were positively associated with MetS, independent of confounders such as age, gender, race/ethnicity, smoking, alcohol intake, physical activity, and urinary creatinine. Compared to tertile 1 (referent), the multivariable adjusted odds ratio (95% confidence interval) of MetS in tertile 3 was 1.51 (1.07–2.12); -trend was 0.02. Conclusions. Urinary BPA levels are positively associated with MetS, in a representative sample of US adults and independent of traditional risk factors for MetS. Future, prospective studies are needed to confirm our findings

Markers of sleep disordered breathing and diabetes mellitus in a multiethnic sample of US adults: results from the national health and nutrition examination survey (2005–2008

We examined gender and ethnic differences in the association between sleep disordered breathing (SDB) and diabetes among 6,522 participants aged ≥20 years from the National Health and Nutrition Examination Survey 2005-08. SDB severity was defined based on an additive summary score including sleep duration, snoring, snorting, and daytime sleepiness. We found that the summary SDB score was significantly associated with diabetes after adjusting for potential confounders in the whole population. Compared to those without any sleep disturbance, the multivariable odds ratio (OR) (95% confidence interval (CI)) of diabetes among those with ≥3 sleep disturbances was 2.04 (1.46-2.87). In sex-specific analyses, this association was significant only in women (OR (95% CI) = 3.68 (2.01-6.72)) but not in men (1.10 (0.59-2.04)), P-interaction = 0.01. However, there were no ethnic differences in this association, P-interaction = 0.7. In a nationally representative sample of US adults, SDB was independently associated with diabetes only in women, but not in men

Dwarf galaxies show little ISM evolution from z∼1z\sim1 to z∼0z\sim0: a spectroscopic study of metallicity, star formation, and electron density

We present gas-phase metallicity measurements for 583 emission line galaxies at $0.3<z<0.85$, including 388 dwarf galaxies with $log(M_{\star}/M_{\odot}) < 9.5$, and explore the dependence of the metallicity on the stellar mass and star formation properties of the galaxies. Metallicities are determined through the measurement of emission lines in very deep ($\sim$7 hr exposure) Keck/DEIMOS spectra taken primarily from the HALO7D survey. We measure metallicity with three strong-line calibrations (O3H$\beta$, R23, and O3O2) for the overall sample, as well as with the faint [Ne III]$\lambda$3869 and [O III]$\lambda$4363 emission lines for 112 and 17 galaxies where robust detections were possible. We construct mass-metallicity relations (MZR) for each calibration method, finding MZRs consistent with other strong-line results at comparable redshift, as well as with $z\sim0$ galaxies. We quantify the intrinsic scatter in the MZR as a function of mass, finding it increases with lower stellar mass. We also measure a weak but significant correlation between increased MZR scatter and higher specific star formation rate. We find a weak influence of SFR in the fundamental metallicity relation as well, with an SFR coefficient of $\alpha=0.21$. Finally, we use the flux ratios of the [O II]$\lambda\lambda$3727,3729 doublet to calculate gas electron density in $\sim$1000 galaxies with $log(M_{\star}/M_{\odot}) < 10.5$ as a function of redshift. We measure low electron densities ($n_e\sim25$ cm$^{-3}$) for $z<1$ galaxies, again consistent with $z\approx0$ conditions, but measure higher densities ($n_e\sim100$ cm$^{-3}$) at $z>1$. These results all suggest that there is little evolution in star-forming interstellar medium conditions from $z\sim1$ to $z=0$, confirmed with a more complete sample of low-mass galaxies than has previously been available in this redshift range.Comment: 22 pages, 10 figures, accepted to Ap

A Review of the Synthesis of Compositionally Complex Ultra-High-Temperature Ceramics

Ultra-high temperature ceramics (UHTC) are a class of ceramics that possess melting points greater than 3000 °C and can withstand temperatures higher than 2000 °C without structural failure. The need to increase the performance inherently leads to the implementation of extreme temperatures, leading to the search for a new class of materials with better thermal properties. Compositionally complex ultra-high temperature ceramics with the inclusion of additional elements, whether resulting in an equimolar or non-equimolar site occupation in the respective sublattices, can improve properties due to the contributions of the configurational entropy. The term compositional complexity can be used as an umbrella term for the class of compositions with 3 or more elements and also their non-equimolar parts. The current review paper is based on the classification of the different compositionally complex ultrahigh temperature ceramics as borides, carbides, nitrides, etc., and reviews the different procedures employed for the bulk or powder synthesis thereof

The Dwarf Galaxy Population at z ∼ 0.7: A Catalog of Emission Lines and Redshifts from Deep Keck Observations

We present a catalog of spectroscopically measured redshifts over $0 < z < 2$ and emission line fluxes for 1440 galaxies. The majority ($\sim$65\%) of the galaxies come from the HALO7D survey, with the remainder from the DEEPwinds program. This catalog includes redshifts for 646 dwarf galaxies with $\log(M_{\star}/M_{\odot}) < 9.5$. 810 catalog galaxies did not have previously published spectroscopic redshifts, including 454 dwarf galaxies. HALO7D used the DEIMOS spectrograph on the Keck II telescope to take very deep (up to 32 hours exposure, with a median of $\sim$7 hours) optical spectroscopy in the COSMOS, EGS, GOODS-North, and GOODS-South CANDELS fields, and in some areas outside CANDELS. We compare our redshift results to existing spectroscopic and photometric redshifts in these fields, finding only a 1\% rate of discrepancy with other spectroscopic redshifts. We measure a small increase in median photometric redshift error (from 1.0\% to 1.3\%) and catastrophic outlier rate (from 3.5\% to 8\%) with decreasing stellar mass. We obtained successful redshift fits for 75\% of massive galaxies, and demonstrate a similar 70-75\% successful redshift measurement rate in $8.5 < \log(M_{\star}/M_{\odot}) < 9.5$ galaxies, suggesting similar survey sensitivity in this low-mass range. We describe the redshift, mass, and color-magnitude distributions of the catalog galaxies, finding HALO7D galaxies representative of CANDELS galaxies up to \textit{i}-band magnitudes of 25. The catalogs presented will enable studies of star formation (SF), the mass-metallicity relation, SF-morphology relations, and other properties of the $z\sim0.7$ dwarf galaxy population.Comment: 23 pages, 19 Figures, updated to version accepted by ApJ

Age at Menarche, the Leg Length to Sitting Height Ratio, and Risk of Diabetes in Middle-Aged and Elderly Chinese Men and Women

To evaluate the associations of age at menarche and the leg length-to-sitting-height ratio, markers of adolescent growth, with risk of diabetes in later life.Information from 69,385 women and 55,311 men, aged 40-74 years from the Shanghai Women's Health Study and Shanghai Men's Health Study, were included in the current analyses. Diabetes status was ascertained through biennial in person follow-up. Cox models, with age as the time scale, were used.There were 2369 cases of diabetes (1831 women; 538 men) during an average of 7.3 and 3.6 years of follow-up of the women and men, respectively. In females, menarche age was inversely associated with diabetes risk after adjustment for birth cohort, education, and income (HR = 0.95, 0.92-0.98). In both genders, leg length-to-sitting-height ratio was inversely related to diabetes (HR = 0.88, 0.80-0.97 for men; HR = 0.91, 0.86-0.96 for women) after adjustment for birth cohort, education, and income. Further adjustment for adult BMI at study enrollment completely eliminated the associations of age at menarche (HR = 0.99, 0.96-1.02) and the leg length-to-sitting-height ratio (HR = 1.00, 0.91-1.10 for men; HR = 1.01, 0.96-1.07 for women) with diabetes risk.Our study suggests that markers of an early age at peak height velocity, i.e. early menarche age and low leg-length-to-sitting height ratio, may be associated with diabetes risk later in life and this association is likely to be mediated through obesity