Multidimensional scaling for orthodontic root resorption

The paper investigates the risk factors for the severity of orthodontic root resorption. The multidimensional scaling (MDS) visualization method is used to investigate the experimental data from patients who received orthodontic treatment at the Department of Orthodontics and Dentofacial Orthopedics, Faculty of Dentistry, “Carol Davila” University of Medicine and Pharmacy, during a period of 4 years. The clusters emerging in the MDS plots reveal features and properties not easily captured by classical statistical tools. The results support the adoption of MDS for tackling the dentistry information and overcoming noise embedded into the data. The method introduced in this paper is rapid, efficient, and very useful for treating the risk factors for the severity of orthodontic root resorption

Mitochondrial respiratory complex I probed by delayed luminescence spectroscopy.

The role of mitochondrial complex I in ultraweak photon-induced delayed photon emission (delayed luminescence (DL)) of human leukemia Jurkat T cells was probed by using complex I targeting agents like rotenone, menadione, and quercetin. Rotenone, a complex I-specific inhibitor, dose-dependently increased the mitochondrial level of reduced nicotinamide adenine dinucleotide (NADH), decreased clonogenic survival, and induced apoptosis. A strong correlation was found between the mitochondrial levels of NADH and oxidized flavin mononucleotide (FMNox) in rotenone-, menadione- and quercetin-treated cells. Rotenone enhanced DL dose-dependently, whereas quercetin and menadione inhibited DL as well as NADH or FMNox. Collectively, the data suggest that DL of Jurkat cells originates mainly from mitochondrial complex I, which functions predomi- nantly as a dimer and less frequently as a tetramer. In individual monomers, both pairs of pyridine nucleotide (NADH/reduced nicotinamide adenine dinucleotide phosphate) sites and flavin (FMN-a/FMN-b) sites appear to bind cooperatively their specific ligands. Enhancement of delayed red-light emission by rotenone suggests that the mean time for one-electron reduction of ubiquinone or FMN-a by the terminal Fe/S center (N2) is 20 or 284 μs, respectively. All these findings suggest that DL spectroscopy could be used as a reliable, sensitive, and robust technique to probe electron flow within complex I in situ. © 2013 Society of Photo-Optical Instrumentatio

LINK BETWEEN SKELETAL RELATIONS AND ROOT RESORPTION IN ORTHODONTIC PATIENTS

External root resorption is one of the possible complications of the orthodontic treatment, severe cases presenting a higher frequency. The aim of the present study was to test the existence of a relation between the severity of root resorption and the sagittal or vertical skeletal relations. A cross-sectional study was conducted on a group of 55 patients with fixed orthodontic devices, applied bimaxillarily for at least 6 months. The sample presented mostly mild or moderate apical root resorption, with an average value of 1.31 mm (standard deviation 0.60). Patients with abnormal sagittal skeletal relations presented a more severe root resorption compared to those with a normal pattern. The tendency towards more severe external root resorption was also noticed in cases with mandibular clockwise rotation and hiperdivergent facial pattern. A good knowledge on the variables associated to severe root resorption is essential for the identification of the high risk patients, as well as for the selection of the best suited treatment alternative in terms of low probability of root resorption occurrence

Total Intravenous Versus Inhalation Anesthesia in Patients Undergoing Laparoscopic Cholecystectomies. Effects on Two Proinflammatory Cytokines Serum Levels: Il-32 and TNF-Alfa.

Introduction: It has been reported that as compared with total intravenous anesthesia (TIVA), inhalation anesthesia is increasing the postoperative level of proinflammatory interleukins

Analyzing Performance in Wholesale Trade Romanian SMEs: Framing Circular Economy Business Scenarios

The study analyzes the performance levels achieved by Romanian wholesaler SMEs from Hunedoara County and to advance some practical courses of action designed to support local entrepreneurs in improving efficiency and in embracing circular economy (CE) practices. We employed cluster and discriminant analyses with a focus on providing an accurate classification of trade SMEs, according to their performance. Three distinct classifications of SMEs resulted in: (i) a class of enterprises displaying high levels of the rates of return, whose business owners exhibited an increased risk appetite and applied investment policies focusing on future development by means of incorporating digital instruments; (ii) a class of SMEs displaying average levels of rates of return, which manage to survive in situations of crisis through maintaining the position previously gained on the market; and (iii) a class of SMEs exhibiting a precarious financial position and employing defensive strategies, with managers who are reluctant to take risks in the innovation processes. Furthermore, we present a cloud computing solution which was tailored for one of the companies from our sample that appeared to be the most likely to carry out the transition from the average SME performance class to the higher class. The main advantages that are brought about by the IT solution in terms of environmental sustainability consist of: improvements in energy efficiency, the decrease in carbon footprints, the lowering of operational costs and the diminishing of the amount of e-waste

Analyzing Performance in Wholesale Trade Romanian SMEs: Framing Circular Economy Business Scenarios

The study analyzes the performance levels achieved by Romanian wholesaler SMEs from Hunedoara County and to advance some practical courses of action designed to support local entrepreneurs in improving efficiency and in embracing circular economy (CE) practices. We employed cluster and discriminant analyses with a focus on providing an accurate classification of trade SMEs, according to their performance. Three distinct classifications of SMEs resulted in: (i) a class of enterprises displaying high levels of the rates of return, whose business owners exhibited an increased risk appetite and applied investment policies focusing on future development by means of incorporating digital instruments; (ii) a class of SMEs displaying average levels of rates of return, which manage to survive in situations of crisis through maintaining the position previously gained on the market; and (iii) a class of SMEs exhibiting a precarious financial position and employing defensive strategies, with managers who are reluctant to take risks in the innovation processes. Furthermore, we present a cloud computing solution which was tailored for one of the companies from our sample that appeared to be the most likely to carry out the transition from the average SME performance class to the higher class. The main advantages that are brought about by the IT solution in terms of environmental sustainability consist of: improvements in energy efficiency, the decrease in carbon footprints, the lowering of operational costs and the diminishing of the amount of e-waste

Potential for Natural Attenuation of Domestic and Agricultural Pollution in Karst Groundwater Environments

In karst areas, anthropogenic contaminants reach the subsurface with detrimental effects on the groundwater ecosystem and downstream springs, which often serve as drinking water sources for the local human communities. We analyzed the water chemistry and microbial community composition in upstream and downstream locations of five hydrokarst systems (HKS) during four seasons. Conductivity and nitrates were higher in the downstream springs than in the pre-karst waters, whereas the concentration of organic matter, considered here as a pollution indicator, was lower. The microbial community composition varied largely between upstream and downstream locations, with multiple species of potentially pathogenic bacteria decreasing in the HKS. Bacteria indicative of pollution decreased as well when passing through the HKS, but potential biodegraders increased. This suggests that the HKS can filter out part of the polluting organic matter and, with it, part of the associated microorganisms. Nevertheless, the water quality, including the presence of pathogens in downstream springs, must be further monitored to control whether the water is appropriate for consumption. In parallel, the human populations located upstream must be advised of the risks resulting from their daily activities, improper stocking of their various wastes and dumping of their refuse in surface streams

Consumption of nutritive supplements during physical activities in Romania: A qualitative study

Abstract The consumption of nutritional supplements by the population that practices physical activities in a regular, organized manner represents a form of scientific interest for professionals interested in analyzing the somatic and biological changes that occur under the influence of the stimuli provided by nutritional supplements. In this context, based on a new statistical model proposed by the authors, we aimed at assessing nutritional supplement consumption efficiency and the effects felt by the consumers in relation to both the achievement of their health goals and the destructuring of the biological processes following the consumption of these supplements. The new model, created by the authors, can be applied to the population of any other state in the world. The methods used in this article are analytical and prospective, and they are based on a qualitative questionnaire applied to 310 Romanian people who practice sports regularly; the sample group being considered representative for the entire population of Romania by the Cochran W.G. test. The results of the study are useful to both the specialists and the people who take nutritional supplements, and they help in improving the perception regarding the efficiency of these products on various categories, as will be seen from the data provided in this study. Moreover, the results of this analysis are also interesting for the providers of products such as pharmacies and authorized distributors, which can scientifically quantify their supply in the market