Unilaterale ulzerationen der fingerspitzen [Unilateral finger tip ulcerations]

none5Eine 56-jährige Frau stellte sich vor mit seit 4 Monaten bestehenden chronisch-rezidivierenden bullösen nekrotischen Läsionen an den Endgliedern des Zeige- und Mittelfi ngers der linken Hand. An denselben Fingern litt sie unter Taubheitsgefühl, Lähmung, nachts verstärktem Schmerz sowie Verlust des Feingefühls. Die Behandlung mit topischen Antibiotika und Kortikosteroiden sowie systemischem Ibuprofen und Prednison führte nicht zur Besserung. Die Patientin hatte keine weiteren Erkrankungen, war Nichtraucherin und verneinte eine Verletzung bei der Arbeit oder im Haushalt [Carpal tunnel syndrome (CTS) is caused by the compression of the median nerve throughout the carpal tunnel. CTS usually presents with the classic triad of nocturnal pain, thenar atrophy and hypoesthesia [1], but other common neurologic symptoms include numbness, unrelenting pins and needles paresthesia, loss of sensitivity and motor defi cits [2]. Moreover, CTS may show cutaneous involvement of the distal phalanges of the second and third fi ngers of the hand [1], as in our patient, who had no thenar atrophy. There are few reports that describe this cutaneous variant [2]]openSavoia F.; Tengattini V.; Valenti L.; Gaddoni G.; Patrizi A.Savoia F.; Tengattini V.; Valenti L.; Gaddoni G.; Patrizi A

Pyoderma gangrenosum in the genital area: successful treatment using adalimumab

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Sudden swelling and redness of the toe

The presence of history of redness and swelling of toe in an infant without history of trauma is typical of hair threat tourniquet syndrome. The treatment simply involves incision and removal of hair fibers. Physicians should be aware of this syndrome because early diagnosis and treatment avoid serious complications

Halolike Phenomenon Around a Café au Lait Spot Superimposed on a Mongolian Spot

An 8-month-old Caucasian infant with neurofibromatosis type 1 presented with a congenital plexiform neurofibroma and multiple caf\ue9 au lait spots. A pale area surrounded one of the caf\ue9 au lait spots located on the left gluteus in the area of dermal melanocytosis. This halolike phenomenon results from the disappearance of the Mongolian spot around the caf\ue9 au lait spots, revealing normal pigmented skin. This sign has been described rarely in the literature and the pathogenic mechanism is unclear

Clubbing/Pseudoclubbing only in Fingernails Previously Affected by Psoriasis

Abstract We report a case of fingernails clubbing in a 55-year-old man suffered since the age of 40 from cutaneous psoriasis. The patient had no clubbing before and had no familial cases of clubbing. Cardiological and pneumological visits revealed no abnormalities. All laboratory tests were within normal limits and X-rays excluded the presence of pachyodermoperiostosis. We made the diagnosis of atypical clubbing exclusively in the fingernails previously affected by psoriasis. It may be that a common mechanism lies at the root of these two phenomena

Focus on five patients treated with cyclosporine up to 62 months

Background: Cyclosporine is a validated treatment for moderate to severe psoriasis. Long-term cyclosporine administration may induce toxic effects. The duration of treatment usually ranges from 10 to 16 weeks. However, some patients may take cyclosporine for a longer time. Aim: The objective of the present study is to evaluate the dose, efficacy and safety in long-term cyclosporine therapy. Patients and methods: We studied the hospital records of patients with psoriasis treated with cyclosporine between 1 January 2009, and 30 April 2015. We decided to focus on patients who, for different reasons, have continued cyclosporine for more than 2 years. Results: Five patients (2.69%) had been assuming cyclosporine for up to 62 months and had achieved a substantial response with no toxic effects. All of them were concerned about recurrence and all patients had personal reasons to prefer Cyclosporine over other drugs, including: familiar history of neurodegenerative disease, desire for motherhood, easy availability on prescription, systemic scleroderma, belenophobia. Conclusion: Cyclosporine is an acceptable monotherapy for psoriasis in selected patients. The prompt discontinuation of treatment usually results in resolution of any eventual toxicity

Focus on pemphigoid associated with malignancies

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Pseudoxanthoma elasticum-ähnliche papilläre dermale Elastolyse bei frontal fibrosierender Alopezie.

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