Temperature dependent electrical resistivity of a single strand of ferromagnetic single crystalline nanowire

We have measured the electrical resistivity of a single strand of a ferromagnetic Ni nanowire of diameter 55 nm using a 4-probe method in the temperature range 3 K-300 K. The wire used is chemically pure and is a high quality oriented single crystalline sample in which the temperature independent residual resistivity is determined predominantly by surface scattering. Precise evaluation of the temperature dependent resistivity ($\rho$) allowed us to identify quantitatively the electron-phonon contribution (characterized by a Debye temperature $\theta_R$) as well as the spin-wave contribution which is significantly suppressed upon size reduction

Buckling without bending: a new paradigm in morphogenesis

A curious feature of organ and organoid morphogenesis is that in certain cases, spatial oscillations in the thickness of the growing "film" are out-of-phase with the deformation of the slower-growing "substrate," while in other cases, the oscillations are in-phase. The former cannot be explained by elastic bilayer instability, and contradict the notion that there is a universal mechanism by which brains, intestines, teeth, and other organs develop surface wrinkles and folds. Inspired by the microstructure of the embryonic cerebellum, we develop a new model of 2d morphogenesis in which system-spanning elastic fibers endow the organ with a preferred radius, while a separate fiber network resides in the otherwise fluid-like film at the outer edge of the organ and resists thickness gradients thereof. The tendency of the film to uniformly thicken or thin is described via a "growth potential". Several features of cerebellum, +blebbistatin organoid, and retinal fovea morphogenesis, including out-of-phase behavior and a film thickness amplitude that is comparable to the radius amplitude, are readily explained by our simple analytical model, as may be an observed scale-invariance in the number of folds in the cerebellum. We also study a nonlinear variant of the model, propose further biological and bio-inspired applications, and address how our model is and is not unique to the developing nervous system.Comment: version accepted by Physical Review

Metabolism of ticagrelor in patients with acute coronary syndromes.

© The Author(s) 2018Ticagrelor is a state-of-the-art antiplatelet agent used for the treatment of patients with acute coronary syndromes (ACS). Unlike remaining oral P2Y12 receptor inhibitors ticagrelor does not require metabolic activation to exert its antiplatelet action. Still, ticagrelor is extensively metabolized by hepatic CYP3A enzymes, and AR-C124910XX is its only active metabolite. A post hoc analysis of patient-level (n = 117) pharmacokinetic data pooled from two prospective studies was performed to identify clinical characteristics affecting the degree of AR-C124910XX formation during the first six hours after 180 mg ticagrelor loading dose in the setting of ACS. Both linear and multiple regression analyses indicated that ACS patients presenting with ST-elevation myocardial infarction or suffering from diabetes mellitus are more likely to have decreased rate of ticagrelor metabolism during the acute phase of ACS. Administration of morphine during ACS was found to negatively influence transformation of ticagrelor into AR-C124910XX when assessed with linear regression analysis, but not with multiple regression analysis. On the other hand, smoking appears to increase the degree of ticagrelor transformation in ACS patients. Mechanisms underlying our findings and their clinical significance warrant further research.Peer reviewedFinal Published versio

Inequalities Detecting Quantum Entanglement for 2⊗d2\otimes d Systems

We present a set of inequalities for detecting quantum entanglement of $2\otimes d$ quantum states. For $2\otimes 2$ and $2\otimes 3$ systems, the inequalities give rise to sufficient and necessary separability conditions for both pure and mixed states. For the case of $d>3$, these inequalities are necessary conditions for separability, which detect all entangled states that are not positive under partial transposition and even some entangled states with positive partial transposition. These inequalities are given by mean values of local observables and present an experimental way of detecting the quantum entanglement of $2\otimes d$ quantum states and even multi-qubit pure states.Comment: 6 page

How do Doctors Decide When to Prescribe Antibiotics in Upper Respiratory Tract Infections?

Purpose: To examine the predictive features which doctors use when prescribing antibiotics in upper respiratory tract infections (URTIs). Method: This is a cross sectional, prospective study done in a teaching university primary care centre in Kuala Lumpur from June to August 2000. Twelve primary care practitioners participated in the study. Each practitioner was asked to record clinical data and prescriptions given to twenty consecutive patients with URTIs using a structured questionnaire for each patient

Reliable Green Routing Using Two Disjoint Paths

Network robustness and throughput can be improved by routing each demand d via two disjoint paths (2DP). However, 2DP routing increases energy usage while providing lower linkutilization and redundancy. In this paper, we address an NP-complete problem, called 2DP-EAR, that aims to switch off redundant nodes and links while guaranteeing two constraints:traffic demands must be afforded 2DP, and maximum link utilization. We design an efficient heuristic, called 2DP by Nodes First (2DP-NF). We have extensively evaluated the performance of 2DP-NF on both real and/or synthetic topologies and traffic demands. As compared to using Shortest Path routing, on the GÉANT network, 2DP-NF can save around 20% energy by switching off links only with negligible effects on path delays and link utilization, even for MLU below 30%. Furthermore, 2DP-NF can obtain 39.7% power savings by switching off both nodes and links on the GÉANT network

First order magnetic transition in CeFe2_2 alloys: Phase-coexistence and metastability

First order ferromagnetic (FM) to antiferromagnetic (AFM) phase transition in doped-CeFe$_2$ alloys is studied with micro-Hall probe technique. Clear visual evidence of magnetic phase-coexistence on micrometer scales and the evolution of this phase-coexistence as a function of temperature, magnetic field and time across the first order FM-AFM transition is presented. Such phase-coexistence and metastability arise as natural consequence of an intrinsic disorder-influenced first order transition. Generality of this phenomena involving other classes of materials is discussed.Comment: 11 pages of text and 3 figure

An objective method for the assessment of fluid injection-induced seismicity and application to tectonically active regions in central California

Changes in seismicity rates, whether of tectonic or of induced origin, can readily be identified in regions where background rates are low but are difficult to detect in seismically active regions. We present a novel method to identify likely induced seismicity in tectonically active regions based on short-range spatiotemporal correlations between changes in fluid injection and seismicity rates. The method searches through the entire parameter space of injection rate thresholds and determines the statistical significance of correlated changes in injection and seismicity rates. Applying our method to Kern County, central California, we find that most earthquakes within the region are tectonic; however, fluid injection contributes to seismicity in four different cases. Three of these are connected to earthquake sequences with events above M4. Each of these sequences followed an abrupt increase in monthly injection rates of at least 15,000 m^3. The probability that the seismicity sequences and the abrupt changes in injection rates in Kern County coincide by chance is only 4%. The identified earthquake sequences display low Gutenberg-Richter b values of ∼0.6–0.7 and at times systematic migration patterns characteristic for a diffusive process. Our results show that injection-induced pressure perturbations can influence seismic activity at distances of 10 km or more. Triggering of earthquakes at these large distances may be facilitated by complex local geology and faults in tectonically active regions. Our study provides the first comprehensive, statistically robust assessment of likely injection-induced seismicity within a large, tectonically active region