Diseño e implementación de una herramienta de email marketing para la Universidad Politécnica Salesiana utilizando tecnologías abiertas

En el presente trabajo se desarrolló una aplicación web, el cual tiene como finalidad el envío masivo de diferentes tipos de correos electrónicos mediante plantillas HTML5 a un grupo determinado de usuarios sin detección de SPAM, se utilizaron tecnologías abiertas como Angular, Java, WildFly, PostgreSQL, etc.In this work a web application was developed, which aims to send different types of mass emails using HTML5 templates to a specific group of users without SPAM detection, open technologies such as Angular, Java, WildFly, PostgreSQL, etc. were used

Distancia entre los ápices del segundo molar y el piso del seno maxilar mediante tomografías computarizadas enero 2019 - septiembre 2020

Antecedentes: El seno maxilar (SM) es una estructura de gran interés debido a su proximidad con las piezas posterosuperiores (1). Conocer la distancia que existe entre dichas estructuras resulta fundamental al realizar la planificación prequirúrgica (2), más aún en el caso del segundo molar por su proximidad con el piso del seno maxilar (PSM) (3–7). Objetivos: Determinar la distancia entre los ápices del segundo molar y el piso del seno maxilar mediante tomografías computarizadas de haz cónico. Metodología: Se recopilaron las tomografías computarizadas de un centro radiológico de Cuenca (enero 2019 - septiembre 2020). Mediante el software Sindexis 4 versión 4.3, se midió la distancia ápico-sinusal, en un corte coronal. La recolección de datos se realizó mediante una plantilla y los resultados se analizaron en el programa IBM SPSS. Resultados: El valor promedio de la distancia ápico-sinusal fue de 0,45mm, 1,36mm y 2,36mm para la raíz mesiovestibular, distovestibular y palatina del lado derecho respetivamente. En el lado izquierdo los valores fueron 0,16mm, 0,66mm y 1,12mm correspondientemente a cada raíz. En ambos casos la raíz mesiovestibular fue la más próxima al PSM. Conclusiones: La raíz mesiovestibular del segundo molar presenta la relación más estrecha con el PSM. En cuanto al grupo etario, la menor distancia se observa en el grupo 3 (lado derecho), y grupo 2 (lado izquierdo). Según el sexo, el valor promedio es similar en los dos grupos.Introduction: The maxillary sinus (MS) is a structure of great interest due to its proximity to the posterior superior dental structures (1). Knowing the distance between these structures is essential when performing pre-surgical planning (2), especially in case of the second molar due to its proximity to the maxillary sinus floor (MSF) (3–7). Objectives: Determine the distance between the apices of the second molar and the maxillary sinus floor using cone beam computed tomography. Methodology: Computed tomography scans were collected from a radiological center in Cuenca (January 2019 - September 2020). Using the Sydexis 4 software version 4.3, the apico-sinus distance was measured in a coronal cut section. The data collection was carried out using a template and the results were analyzed in the IBM SPSS program. Results: The average value of the apico-sinus distance was 0.45mm, 1.36mm and 2.36mm for the mesiobuccal, distobuccal and palatal roots on the right side. On the left side the values were 0.16mm, 0.66mm and 1.12mm respectively. In both cases the mesiobuccal root was the closest to the MSF. Conclusions: The mesiobuccal root of the second molar has the closest relationship with the MSF. Regarding the age group, the shortest distance is observed in group 3 (right side), and group 2 (left side). According to the sex, the average value is similar in the two groups.OdontólogoCuenc

Powering prescription:Mitochondria as "Living Drugs" - Definition, clinical applications, and industry advancements

Mitochondria's role as engines and beacons of metabolism and determinants of cellular health is being redefined through their therapeutic application as "Living Drugs" (LDs). Artificial mitochondrial transfer/transplant (AMT/T), encompassing various techniques to modify, enrich, or restore mitochondria in cells and tissues, is revolutionizing acellular therapies and the future of medicine. This article proposes a necessary definition for LDs within the Advanced Therapeutic Medicinal Products (ATMPs) framework. While recognizing different types of LDs as ATMPs, such as mesenchymal stem cells (MSCs) and chimeric antigen receptor T (CAR T) cells, we focus on mitochondria due to their unique attributes that distinguish them from traditional cell therapies. These attributes include their inherent living nature, diverse sources, industry applicability, validation, customizability for therapeutic needs, and their capability to adapt and respond within recipient cells. We trace the journey from initial breakthroughs in AMT/T to the current state-of-the-art applications by emerging innovative companies, highlighting the need for manufacturing standards to navigate the transition of mitochondrial therapies from concept to clinical practice. By providing a comprehensive overview of the scientific, clinical, and commercial landscape of mitochondria as LDs, this article contributes to the essential dialogue among regulatory agencies, academia, and industry to shape their future in medicine