Flatness, weakly lex colimits, and free exact completions

We capture in the context of lex colimits, introduced by Garner and Lack, the universal property of the free regular and Barr-exact completions of a weakly lex category. This is done by introducing a notion of flatness for functors $F\colon\mathcal C\to\mathcal E$ with lex codomain, and using this to describe the universal property of free $\Phi$-exact completions in the absence of finite limits, for any given class $\Phi$ of lex weights. In particular, we shall give necessary and sufficient conditions for the existence of free lextensive and free pretopos completions in the non-lex world, and prove that the ultraproducts, in the categories of models of such completions, satisfy an universal property

Pengaruh kebiasaan belajar dan lingkungan sekolah terhadap hasil belajar matematika melalui sikap berpikir kritis siswa SMP di kecamatan Samarinda seberang

Penelitian ini bertujuan untuk mengetahui (1) pengaruh kebiasaan belajar terhadap hasil belajar matematika, (2) pengaruh lingkungan sekolah terhadap hasil belajar matematika, (3) pengaruh berpikir kritis terhadap hasil belajar matematika, (4) pengaruh kebiasaan belajar Terhadap berpikir kritis, (5) pengaruh lingkungan sekolah pengaruh lingkungan sekolah, (6) pengaruh kebiasaan belajar terhadap hasil belajar matematika melalui berpikir kritis, (7) pengaruh lingkungan sekolah terhadap hasil belajar matematika melalui berpikir kritis, (8) pengaruh kebiasaan belajar, pengaruh lingkungan sekolah dan berpikir kritis terhadap hasil belajar matematika. Jenis penelitian ini adalah penelitian kuantitatif menggunakan metode cross sectional correlation. Populasi penelitian ini adalah siswa kelas VIII SMP Kecamatan Samarinda Seberang yang berjumlah 392 siswa dengan ukuran sampel 80 responden dan pengambilan sampel menggunakan simple random sampling. Instrumen yang digunakan dalam penelitian ini adalah angket dengan teknik analisis data menggunakan analisis jalur (path analysis). Hasil penelitian ini menunjukkan bahwa pertama tidak terdapat pengaruh yang signifikan kebiasaan belajar terhadap hasil belajar sebesar 0,4%, kedua terdapat pengaruh yang signifikan lingkungan terhadap hasil belajar sebesar 13,4%, ketiga terdapat pengaruh yang signifikan berpikir kritis terhadap hasil belajar sebesar 29%, keempat terdapat pengaruh yang signifikan kebiasaan belajar terhadap berpikir kritis sebesar 29,2%, kelima tidak terdapat pengaruh yang signifikan lingkungan terhadap berpikir kritis sebesar 1,7%, keenam terdapat pengaruh yang signifikan kebiasaan belajar terhadap hasil belajar melalui berpikir kritis sebesar 8,86%, ketujuh terdapat pengaruh yang signifikan lingkungan terhadap hasil belajar melalui berpikir kritis sebesar 13,89%, kedelapan pengaruh kebiasaan belajar, lingkungan dan berpikir kritis terhadap hasil belajar sebesar 14,4%

Evaluasi kegiatan diklat pembuatan butir soal ujian nasional (UN) jenjang SMP/MTs kabupaten Kutai Timur tahun 2017

Evaluasi kegiatan diklat Pembuatan Butir Soal UN Jenjang SMP/MTs. Kab. Kutim Tahun 2017 ini bertujuan untuk mendeskripsikan tentang: (1) tingkat kepuasan peserta diklat, (2) terjadi atau tidaknya prningkatan pengetahuan dan keterampilan peserta diklat. Untuk mencapai tujuan evaluai tersebut digunakan model evaluasi dari Donald L. Kirkpatrick atau biasa disingkat Modeln Kirkpatrick yang dibatasi pada level I (Reaksi) dan level II (Pengetahuan). Hasil analisis evaluasi dan pembahasan menunjukan bahwa pada diklat Pembuatan Butir Soal Ujian Nasional Jenjang SMP/MTs. Kab. Kutim Tahun 2017: (1) tingkat kepuasan peserta diklat di kedua kelas MIPA dan Bahasa dari hari ke hari selalu terjadi peningkatan, dan pada hari ke – 4 seluruh peserta diklat (100 %) merasa puas (senang dan sangat senang) dalam mengikuti kegiatan diklat, (2) telah terjadi peningkatan pengetahuan dan keterampilan yang tinggi pada peserta diklat, yakni sebesar 24.85 di kelas MIPA dan 14.38 di kelas Bahasa

Fotoaferesi extracorporea come terapia di prima linea nel trattamento della GVHD cronica dopo trapianto allogenico di cellule staminali

Introduzione. La malattia del trapianto verso l’ospite cronica (cGVHD) è la più importante complicanza dopo trapianto di cellule staminali emopoietiche. La terapia standard è l’associazione di ciclosporina (CyA) e cortisone; le complicanze infettive correlate alla terapia immunosoppressiva (ISS) o la insoddisfacente risposta al trattamento sono la principale causa di mortalità. La fotoaferesi extracorporea (ECP) si è dimostrata efficace nel trattamento della cGVHD, ma il suo utilizzo è stato prevalentemente limitato alla cGVHD resistente a trattamento di prima linea. Scopo dello studio. Il presente studio pilota ha l’obiettivo di valutare la fattibilità di un programma di ECP in associazione a terapia standard per il trattamento di prima linea della cGVHD ad alto rischio. Il rischio elevato si definisce in base alla presenza di parametri che predicono una elevata mortalità cGVHD correlata. Obiettivi secondari sono la risposta e la incidenza di complicanze (sicurezza). Pazienti. Su 10 pazienti che rispettavano i criteri di arruolamento, 2 hanno rifiutato di aderire allo studio per problemi logistici o rifiuto di un protocollo sperimentale, 8 sono stati arruolati. L’età media è stata di 40 anni. Il donatore era un donatore familiare HLA identico in 7 casi e un donatore non familiare in 1 caso. Tutti i pazienti presentavano cGVHD estesa o moderato/severa; lo score prognostico (secondo Akpek) era >0 in 3/8 pazienti. Trattamento. I pazienti hanno iniziato il trattamento con Prednisone (PDN) 1 mg/kg e CyA alla diagnosi di cGVHD; la ECP è stata iniziata con una frequenza di 4 sedute / mese nei primi 3 mesi e 2 / mese per i successivi 9 mesi; PDN e CyA sono stati lentamente scalati sino alla sospensione se possibile, altrimenti modulati. La durata dello studio è stata di 1 anno. I criteri di uscita dallo studio erano la sospensione della ECP, la necessità di inserire altri farmaci immunosoppressivi per progressione della cGVHD o infezioni severe. La risposta è stata valutata secondo criteri standard come progressione, risposta parziale (PR), ottima PR (vgPR) o risposta completa (CR). Risultati. La aderenza al protocollo è stata: 6/8 pazienti a 3 mesi, 4/8 a 6 e 9 mesi, 3/8 a 12 mesi; l’uscita dallo studio è stata determinata da complicanze infettive in 2 pazienti, sospensione della ECP in 1 paziente a acusa di una trombosi correlata al catetere venoso (CV) femorale inserito per le procedure di ECP, in 2 pazienti per chiara progressione della cGVHD. Nei pazienti valutabili la risposta (CR + vgPR / <=PR) per trimestre è stata 4/6, 2/4 and 3/4 al I, II e III trimestre rispettivamente; dopo il IV trimestre di trattemento sono state osservate 1 vgPR, 2 PR e 1 progressione. Complicanze sono state osservate in 4 pazienti per un totale di 9 episodi: 1 caso di polmonite, 1 caso di infezione delle vie urinarie, 3 casi di riattivazione di CMV, 1 caso di condilomatosi, 1 caso di infezione CVC correlata, 1 caso di trombosi CV femorale correlata, 1 caso di sindrome uremicoemolitica. Ad 1 anno 2 pazienti su 8 sono deceduti (1 caso per mortalità trapianto correlata, 1 caso per recidiva). Conclusioni. La ECP in associazione a terapia standard è fattibile; la incidenza di complicanze sembra essere sovrapponibile a quella osservata nei pazienti non sottoposti a ECP. Per valutare adeguatamente la risposta e la sicurezza di questo trattamento sarà necessario un numero più ampio di pazienti.Background. Chronic graft versus host disease (cGVHD) is the major late complication after allogeneic stem cell transplantation. Standard therapy is steroid and Cyclosporine-A (CyA); however, immune suppression (ISS) related infections or unresponsiveness to ISS, are major mortality causes. Extracorporeal photopheresis (ECP) has shown activity in treatment of cGVHD, but its use has been limited to first-line-unresponsive cGVHD. Aim of the study. This is a single center pilot study testing feasibility of a programme of photopheresis in association with standard therapy as first line treatment in high risk cGVHD. High risk was defined as the presence of parameters predicting high cGVHD-related mortality. Secondary objectives were response and complications incidence. Patients. Among 10 pts fitting enrolling criteria, 2 refused due to logistic problem or low compliance with the procedure, 8 were enrolled. Median age was 40. Donor was HLA identical sibling in 7 cases and MUD in 1. All cases presented with extensive/moderate-severe cGVHD; Akpek score was > 0 in 3/8 pts. Treatment plan. Pts started with Prednison (PDN) 1 mg/kg and CyA at cGVHD diagnosis; ECP was started with a frequency of 4 application/month in the first 3 months and 2/month for the subsequent 9 months; PDN and CyA were slowly reduced until suspension, or otherwise modulated. Study duration was 1 year. Pts were ruled out the study in case of ECP suspension, requirement of other ISS drugs in case of GVHD progression unresponsive to standard therapy, or severe infections. Response was evaluated with standard criteria, as progression, partial response (PR), very good PR (vgPR) or complete response (CR). Results. Adherence to protocol was: 6/8 pts at 3 months, 4/8 at 6 and 9 months, 3/8 at 12 mm; exit from the study was due to infectious complications (2), ECP suspension due to venous access related thrombosis (1) and clear cGVHD progression (2). In evaluable pts, response (CR+very good PR / <=PR) per trimester was 4/6, 2/4 and 3/4 at I, II and III respectively; at the IV trimester, 1 very good PR, 2 PR and 1 progression were observed. Complications were observed in 4 pts with : 1 case of pneumonia, 1 case of urinary tract infection, 3 cases of CMV antigenemia activation, 1 case of condilomatosis, 1 case of catheter related infection, 1 case of catheter related thrombosis and 1 case of hemolitic uremic syndrome. At 1 year, 2/8 pts died (1 TRM, 1 relapse). Conclusion. ECP in association with standard therapy is feasible; complications incidence seems to be similar to those observed in patients not treated with ECP; a larger group of patients is needed to evaluate response in this setting

Enriched universal algebra

Following the classical approach of Birkhoff, we introduce enriched universal algebra. Given a suitable base of enrichment $\mathcal V$, we define a language $\mathbb L$ to be a collection of $(X,Y)$-ary function symbols whose arities are taken among the objects of $\mathcal V$. The class of $\mathbb L$-terms is constructed recursively from the symbols of $\mathbb L$, the morphisms in $\mathcal V$, and by incorporating the monoidal structure of $\mathcal V$. Then, $\mathbb L$-structures and interpretations of terms are defined, leading to enriched equational theories. In this framework we prove several fundamental theorems of universal algebra, including the characterization of algebras for finitary monads on $\mathcal V$ as models of an equational theories, and several Birkhoff-type theorems

Flat vs. filtered colimits in the enriched context

The importance of accessible categories has been widely recognized; they can be described as those freely generated in some precise sense by a small set of objects and, because of that, satisfy many good properties. More specifically finitely accessible categories can be characterized as: (a) free cocompletions of small categories under filtered colimits, and (b) categories of flat presheaves on some small category. The equivalence between (a) and (b) is what makes the theory so general and fruitful. Notions of enriched accessibility have also been considered in the literature for various bases of enrichment, such as $\mathbf{Ab},\mathbf{SSet},\mathbf{Cat}$ and $\mathbf{Met}$. The problem in this context is that the equivalence between (a) and (b) is no longer true in general. The aim of this paper is then to: (1) give sufficient conditions on $\mathcal V$ so that (a) $\Leftrightarrow$ (b) holds; (2) give sufficient conditions on $\mathcal V$ so that (a) $\Leftrightarrow$ (b) holds up to Cauchy completion; (3) explore some examples not covered by (1) or (2).Comment: Revised version: major changes to the introduction, added some words at the beginning of Sect. 3 and 4. To appear on Advances in Mathematic

Accessible categories with a class of limits

In this paper we characterize those accessible $\mathcal V$-categories that have limits of a specified class. We do this by introducing the notion of companion $\mathfrak C$ for a class of weights $\Psi$, as a collection of special types of colimit diagrams that are compatible with $\Psi$. We then characterize the accessible $\mathcal V$-categories with $\Psi$-limits as those accessibly embedded and $\mathfrak C$-virtually reflective in a presheaf $\mathcal V$-category, and as the $\mathcal V$-categories of $\mathfrak C$-models of sketches. This allows us to recover the standard theorems for locally presentable, locally multipresentable, and locally polypresentable categories as instances of the same general framework. In addition, our theorem covers the case of any weakly sound class $\Psi$, and provides a new perspective on the case of weakly locally presentable categories.Comment: Journal version. Some references added, as well as 4.10, 4.11, 4.18, 4.20(4

A prospective study comparing quantitative Cytomegalovirus (CMV) polymerase chain reaction in plasma and pp65 antigenemia assay in monitoring patients after allogeneic stem cell transplantation

BACKGROUND: Low levels of Cytomegalovirus (CMV) viral load are frequently detected following allogeneic stem cell transplantation (SCT) and CMV disease may still develop in some allogeneic SCT patients who have negative pp65-antigenemia (pp65-Ag) or undetectable DNA. Pp65Ag is a sensitive method to diagnose CMV infection. Quantitative CMV-DNA PCR assay in plasma has been proposed to monitor CMV infection in SCT patients. We evaluated the clinical utility of pp65Ag and PCR assay in plasma of SCT recipients. METHODS: In a prospective longitudinal study, 38 consecutive patients at risk of CMV infection (donor and/or recipient CMV seropositive) were weekly monitored for CMV infection by both quantitative CMV-PCR in plasma (COBAS AMPLICOR CMV MONITOR) and pp65 Ag, during the first 100 days after SCT. RESULTS: A total of 534 blood samples were simultaneously analysed for pp65Ag and PCR. Overall, 28/38 patients (74%) had active CMV infection within 100 days from SCT. In 16 patients, CMV was first detected by pp65 Ag alone; in 5 patients by both methods and in 6 by PCR assay alone; one patient had CMV biopsy-proven intestinal disease without pp65Ag and PCR assays positivity before CMV disease. Overall, three patients developed intestinal CMV disease (7.9%): one had negative both pp65Ag and PCR assays before CMV disease, one had disease and concomitant positivity of both methods, while in the remaining patient, only pp65Ag was positive before CMV disease. CONCLUSION: Plasma PCR(COBAS AMPLICOR CMV MONITOR) and pp65Ag assays were effective in detecting CMV infection, however, discordance between both methods were frequently observed. Plasma PCR and pp65Ag assays may be complementary for diagnosis and management of CMV infection

Borneo, Jurnal Ilmu Pendidikan volume XI, nomor 2, Desember 2017

1. Penerapan Model Make A Match pada Pokok Bahasan Tata Nama Senyawa untuk Meningkatkan Hasil Belajar Siswa Kelas X IPA 2 SMA Negeri 1 Sebulu 2. Membangun Integritas di Satuan Pendidikan M. Yani 3. Meningkatkan Prestasi Belajar Pendidikan Agama Kristen dalam Materi Menjaga dan Memelihara Alam dengan Menggunakan Model Pembelajaran Problem Solving di SMP Negeri 1 Rantau Pulung Tatag Setyawan 4. Meningkatkan Hasil Belajar Matematika melalui Metode Pembelajaran Tuntas pada Materi Komposisi Fungsi di Kelas XI MIA 3 SMA Negeri 1 Sangatta Utara Hasnah Sahabuddin 5. Upaya Meningkatkan Kinerja Guru melalui Supervisi di SMP Negeri 2 Sangatta Selatan Jamalludin 6. Peningkatan Hasil Belajar Sosiologi melalui Pembelajaran Kooperatif Jigsaw II di Kelas XI IPS 2 SMA Negeri 1 Sangatta Selatan Esti Lugondang 7. Pengaruh Kebiasaan Belajar dan Lingkungan Sekolah terhadap Hasil Belajar Matematika melalui Sikap Berpikir Kritis Siswa SMP di Kecamatan Samarinda Seberang Tendas Teddy Soesilo 8. Implementasi Sistem Penjaminan Mutu Internal (SPMI) melalui Program Pendampingan di SMP Negeri 2 Sajira Kabupaten Lebak Lela Foni Sulistiyowati 9. Optimaliasi Peran LPMP Papua dalam Peningkatan Kualitas Guru IPA di Propinsi Papua Gendro Mulyono 10. Penerapan Teori Belajar Bruner dalam Pembelajaran Penjumlahan dan Pengurangan Dua Bilangan Sampai 20 di Kelas I SD/MI Dalyana 11. Upaya Meningkatkan Keterampilan Peserta Diklat Dalam Membuat Laporan Karya Inovatif Menggunakan Metode PPT Pada Diklat Karya Tulis Ilmiah (KTI) Samodro 12. Penerapan Sistem Penjaminan Mutu Internal dan Benchmarking untuk Meningkatkan Mutu pada Satuan Pendidikan Kaolan 13. Evaluasi Program Pendidikan Haksan Darwangsa 14. Meningkatkan Kompetensi Pedagogil Guru Pendidikan Dasar di daerah 3T melalui Pelatihan Wiwik Setiawati 15. Implementasi Kurikulum 2013 Jenjang Sekolah Dasar di Kabupaten Berau Kalimantan Timur Suharman 16. Pengaruh Pemberian Tugas terhadap Peningkatan Kompetensi Guru dalam Sistim Penjaminan Mutu Internal di SDN 008 Mamahak Besar Mahakam Ulu Ahmad Husain

Borneo Jurnal Ilmu Pendidikan LPMP Kalimantan Timur Vol. VII, No. 2, Juni 2013

Pada edisi ini semua tulisan yang dimuat dalam Jurnal Borneo berasal dari luar LPMP yaitu Dosen, pengawas, Kepala Sekolah, dan guru. Buku ini terdiri dari beberapa judul jurnal yaitu, Perbedaan hasil belajar matematika menggunakan model pembelajaran kooperatif dan pembelajaran konvensional siswa kelas X SMA Negeri 1 Tenggarong tahun pembelajaran 2011/2012, Potret mutu pendidikan Provinsi Kalimantan Timur berbasis EDS tahun 2012, Peningkatan hasil belajar matematika dengan model pembelajaran Picture And Picture materi pokok keliling dan luas bidang datar di kelas VII-4 SMP Negeri 1 Balikpapan tahun pembelajaran 2011/2012, Upaya peningkatan kemampuan/prestasi belajar Bahasa Indonesia dalam pembelajaran apresiasi sastra dengan menggunakan Teknik Media Power Poin terpadu bagi siswa SMK Negeri 3 Balikpapan, Meningkatkan hasil belajar seni rupa SMP Negeri 2 Anggana melalui model pembelajaran Kooperatif Jigsaw, Penerapan metode demonstrasi dalam pembelajaran praktek sholat di kelas III SDN 026 Sungai Kunjang, Peningkatan kemampuan guru dalam menyusun Rencana Pelaksanaan Pembelajaran (RPP) melalui supervisi akademik di SMA Negeri 7 Penajam Paser Utara, Meningkatkan hasil belajar siswa pada materi teks melalui pembelajaran Kooperatif Deskriptif Number Head Together (NHT) di kelas B VII D SMP Negeri 1 Sengatta Selatan, Peningkatan hasil belajar matematika siswa melalui pembelajaran model Tutor Sebaya di kelas X AP-2 SMK Negeri 2 Balikpapan tahun pembelajaran 2008/2009, Upaya membangkitkan minat siswa dalam pembelajaran praktek ansambel melalui kegiatan ekstra kurikuler menggunakan metode Eksperiental Learning bagi siswi - siswi kelas V dan kelas VI di SDN 004 Sepaku PPU, Hubungan pengelolaan kelas dengan prestasi belajar fisika melalui monitoring di SMP Negeri 11 Samarinda Tahun 2011/2012, Pembelajaran konsep pengukuran dengan menggunakan model penemuan terbimbing pada kelas 7C SMP Negeri 1 Penajam Paser Utara, Upaya peningkatan prestasi belajar fisika dengan metode eksperimen secara efektif kompetensi dasar bunyi kelas VII SBI – 1 Semester II tahun pembelajaran 2008/2009 SMP Negeri 1 Balikpapan rintisan sekolah bertaraf internasional, Pelaksanaan sekolah berwawasan gender di Kota Bontang: analisis Gap (Gender Analysis Pathway), Manajemen keuangan sekolah berbasis mutu pendidikan