Reproducibility and validity of a diet quality index for children assessed using a FFQ

The diet quality index (DQI) for preschool children is a new index developed to reflect compliance with four main food-based dietary guidelines for preschool children in Flanders. The present study investigates: (1) the validity of this index by comparing DQI scores for preschool children with nutrient intakes, both of which were derived from 3d estimated diet records; (2) the reproducibility of the DQI for preschoolers based on a parentally reported forty-seven-item FFQ DQI, which was repeated after 5 weeks; (3) the relative validity of the FFQ DQI with 3d record DQI scores as reference. The study sample included 510 and 58 preschoolers (2-5-6.5 years) for validity and reproducibility analyses, respectively. Increasing 3d record DQI scores were associated with decreasing consumption of added sugars, and increasing intakes of fibre, water, Ca and many micronutrients. Mean FFQ DQI test-retest scores were not significantly different: 72 (so 11) v. 71 (Si) 10) (P-=0-218) out of a maximum of 100. Mean 3d record DQI score (66 (so 10)) was significantly lower than mean FFQ DQI (71 (so 10);

Evanescence in Coined Quantum Walks

In this paper we complete the analysis begun by two of the authors in a previous work on the discrete quantum walk on the line [J. Phys. A 36:8775-8795 (2003) quant-ph/0303105 ]. We obtain uniformly convergent asymptotics for the "exponential decay'' regions at the leading edges of the main peaks in the Schr{\"o}dinger (or wave-mechanics) picture. This calculation required us to generalise the method of stationary phase and we describe this extension in some detail, including self-contained proofs of all the technical lemmas required. We also rigorously establish the exact Feynman equivalence between the path-integral and wave-mechanics representations for this system using some techniques from the theory of special functions. Taken together with the previous work, we can now prove every theorem by both routes.Comment: 32 pages AMS LaTeX, 5 figures in .eps format. Rewritten in response to referee comments, including some additional references. v3: typos fixed in equations (131), (133) and (134). v5: published versio

Topological Phases in Graphitic Cones

The electronic structure of graphitic cones exhibits distinctive topological features associated with the apical disclinations. Aharonov-Bohm magnetoconductance oscillations (period Phi_0) are completely absent in rings fabricated from cones with a single pentagonal disclination. Close to the apex, the local density of states changes qualitatively, either developing a cusp which drops to zero at the Fermi energy, or forming a region of nonzero density across the Fermi energy, a local metalization of graphene.Comment: 4 pages, RevTeX 4, 3 PostScript figure

Evaluation of Modern 3He(alpha,gamma)7Be Data

In both the Sun and the early universe, the 3He(alpha,gamma)7Be reaction plays a key role. The rate of this reaction is the least certain nuclear input needed to calculate both the primordial 7Li abundance in big bang nucleosynthesis (BBN) and the solar neutrino flux. Taking advantage of several recent highly precise experiments, we analyse modern 3He(alpha,gamma)7Be data using a robust and minimally model dependent approach capable of handling discrepant data sets dominated by systematic rather than statistical errors. We find S34(0)=0.580 pm 0.043(0.054) keV b at the 68.3(95.4)% confidence level.Comment: 13 pages, 5 figure

Data compression for the First G-APD Cherenkov Telescope

The First Geiger-mode Avalanche photodiode (G-APD) Cherenkov Telescope (FACT) has been operating on the Canary island of La Palma since October 2011. Operations were automated so that the system can be operated remotely. Manual interaction is required only when the observation schedule is modified due to weather conditions or in case of unexpected events such as a mechanical failure. Automatic operations enabled high data taking efficiency, which resulted in up to two terabytes of FITS files being recorded nightly and transferred from La Palma to the FACT archive at ISDC in Switzerland. Since long term storage of hundreds of terabytes of observations data is costly, data compression is mandatory. This paper discusses the design choices that were made to increase the compression ratio and speed of writing of the data with respect to existing compression algorithms. Following a more detailed motivation, the FACT compression algorithm along with the associated I/O layer is discussed. Eventually, the performances of the algorithm is compared to other approaches.Comment: 17 pages, accepted to Astronomy and Computing special issue on astronomical file format

Perturbative Approach to the Quasinormal Modes of Dirty Black Holes

Using a recently developed perturbation theory for uasinormal modes (QNM's), we evaluate the shifts in the real and imaginary parts of the QNM frequencies due to a quasi-static perturbation of the black hole spacetime. We show the perturbed QNM spectrum of a black hole can have interesting features using a simple model based on the scalar wave equation.Comment: Published in PR

Coarse-Grained Finite-Temperature Theory for the Condensate in Optical Lattices

In this work, we derive a coarse-grained finite-temperature theory for a Bose condensate in a one-dimensional optical lattice, in addition to a confining harmonic trap potential. We start from a two-particle irreducible (2PI) effective action on the Schwinger-Keldysh closed-time contour path. In principle, this action involves all information of equilibrium and non-equilibrium properties of the condensate and noncondensate atoms. By assuming an ansatz for the variational function, i.e., the condensate order parameter in an effective action, we derive a coarse-grained effective action, which describes the dynamics on the length scale much longer than a lattice constant. Using the variational principle, coarse-grained equations of motion for the condensate variables are obtained. These equations include a dissipative term due to collisions between condensate and noncondensate atoms, as well as noncondensate mean-field. To illustrate the usefulness of our formalism, we discuss a Landau instability of the condensate in optical lattices by using the coarse-grained generalized Gross-Pitaevskii hydrodynamics. We found that the collisional damping rate due to collisions between the condensate and noncondensate atoms changes sign when the condensate velocity exceeds a renormalized sound velocity, leading to a Landau instability consistent with the Landau criterion. Our results in this work give an insight into the microscopic origin of the Landau instability.Comment: 38 pages, 2 figures. Submitted to Journal of Low Temperature Physic

Identification of SOX2 as a novel glioma-associated antigen and potential target for T cell-based immunotherapy

Prognosis for patients suffering from malignant glioma has not substantially improved. Specific immunotherapy as a novel treatment concept critically depends on target antigens, which are highly overexpressed in the majority of gliomas, but the number of such antigens is still very limited. SOX2 was identified by screening an expression database for transcripts that are overexpressed in malignant glioma, but display minimal expression in normal tissues. Expression of SOX2 mRNA was further investigated in tumour and normal tissues by real-time PCR. Compared to cDNA from pooled normal brain, SOX2 was overexpressed in almost all (9 out of 10) malignant glioma samples, whereas expression in other, non-malignant tissues was almost negligible. SOX2 protein expression in glioma cell lines and tumour tissues was verified by Western blot and immunofluorescence. Immunohistochemistry demonstrated SOX2 protein expression in all malignant glioma tissues investigated ranging from 6 to 66% stained tumour cells. Human leucocyte antigen-A*0201-restricted SOX2-derived peptides were tested for the activation of glioma-reactive CD8+ cytotoxic T lymphocytes (CTLs). Specific CTLs were raised against the peptide TLMKKDKYTL and were capable of lysing glioma cells. The abundant and glioma-restricted overexpression of SOX2 and the generation of SOX2-specific and tumour-reactive CTLs may recommend this antigen as target for T-cell-based immunotherapy of glioma

Can One Trust Quantum Simulators?

Various fundamental phenomena of strongly-correlated quantum systems such as high-$T_c$ superconductivity, the fractional quantum-Hall effect, and quark confinement are still awaiting a universally accepted explanation. The main obstacle is the computational complexity of solving even the most simplified theoretical models that are designed to capture the relevant quantum correlations of the many-body system of interest. In his seminal 1982 paper [Int. J. Theor. Phys. 21, 467], Richard Feynman suggested that such models might be solved by "simulation" with a new type of computer whose constituent parts are effectively governed by a desired quantum many-body dynamics. Measurements on this engineered machine, now known as a "quantum simulator," would reveal some unknown or difficult to compute properties of a model of interest. We argue that a useful quantum simulator must satisfy four conditions: relevance, controllability, reliability, and efficiency. We review the current state of the art of digital and analog quantum simulators. Whereas so far the majority of the focus, both theoretically and experimentally, has been on controllability of relevant models, we emphasize here the need for a careful analysis of reliability and efficiency in the presence of imperfections. We discuss how disorder and noise can impact these conditions, and illustrate our concerns with novel numerical simulations of a paradigmatic example: a disordered quantum spin chain governed by the Ising model in a transverse magnetic field. We find that disorder can decrease the reliability of an analog quantum simulator of this model, although large errors in local observables are introduced only for strong levels of disorder. We conclude that the answer to the question "Can we trust quantum simulators?" is... to some extent.Comment: 20 pages. Minor changes with respect to version 2 (some additional explanations, added references...