GoCo: planning expressive commitment protocols

Acknowledgements We gratefully thank those who shared their code with us. Special thanks to Ugur Kuter. We thank the anonymous reviewers, and also acknowledge with gratitude the reviewers at ProMAS’11, AAMAS’13, AAAI’13, and AAMAS’15, where preliminary parts of this work appeared. FM thanks the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for the support within process numbers 306864/2013-4 under the PQ fellowship and 482156/2013-9 under the Universal project programs. NYS acknowledges support of the AUB University Research Board Grant Number 102853 and the OSB Grant OFFER_C1_2013_2014.Peer reviewe

Aligning Monitoring and Compliance Requirements in Evolving Business Networks

Dynamic business networks (BNs) are intrinsically characterised by change. Compliance requirements management, in this context, may become particularly challenging. Partners in the network may join and leave the collaboration dynamically and tasks over which compliance requirements are specified may be consequently delegated to new partners or backsourced by network participants. This paper considers the issue of aligning the compliance requirements in a BN with the monitoring requirements they induce on the BN participants when change (or evolution) occurs. We first provide a conceptual model of BNs and their compliance requirements, introducing the concept of monitoring capabilities induced by compliance requirements. Then, we present a set of mechanisms to ensure consistency between the monitoring and compliance requirements when BNs evolve, e.g. tasks are delegated or backsourced in-house. Eventually, we discuss a prototype implementation of our framework, which also implements a set of metrics to check the status of a BN in respect of compliance monitorability

Collecfion of chickpea germplasm in Madhya Pradesh, India and their agronomic evaldation

Three-hundred-and-fifty-one seed samples of local chickpeas (Cicer arietinum L.) were collected in Madhya Pradesh, India, during 1986 and 1987 for the world germplasm collection maintained at ICRISAT Centre. These missions were joint efforts of the International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Jawaharlal Nehru Krishi Vishwa Vidyalaya(JNKVV), Jabalpur, and the National Bureau of Plant Genetic Resources (NBPGR), New Delhi. Vast variability was noticed for several morphoagronomic traits of chickpea during these missions. The collected samples were sorted out into relatively homogenous samples and later grouped into five homogenous sets for easy evaluation. These sets were evaluated for eight agronomic traits at ICR/SAT Centre (18°N) and Gwalior (26°N). The performance of accessions for seeds per pod and 100-seed mass were almost similar at both locations whereas other agronomic characters varied with locations. The accessions with superior performance in five sets and two locations were identified

Leveraging semantic resources in diversified query expansion

A search query, being a very concise grounding of user intent, could potentially have many possible interpretations. Search engines hedge their bets by diversifying top results to cover multiple such possibilities so that the user is likely to be satisfied, whatever be her intended interpretation. Diversified Query Expansion is the problem of diversifying query expansion suggestions, so that the user can specialize the query to better suit her intent, even before perusing search results. In this paper, we consider the usage of semantic resources and tools to arrive at improved methods for diversified query expansion. In particular, we develop two methods, those that leverage Wikipedia and pre-learnt distributional word embeddings respectively. Both the approaches operate on a common three-phase framework; that of first taking a set of informative terms from the search results of the initial query, then building a graph, following by using a diversity-conscious node ranking to prioritize candidate terms for diversified query expansion. Our methods differ in the second phase, with the first method Select-Link-Rank (SLR) linking terms with Wikipedia entities to accomplish graph construction; on the other hand, our second method, Select-Embed-Rank (SER), constructs the graph using similarities between distributional word embeddings. Through an empirical analysis and user study, we show that SLR ourperforms state-of-the-art diversified query expansion methods, thus establishing that Wikipedia is an effective resource to aid diversified query expansion. Our empirical analysis also illustrates that SER outperforms the baselines convincingly, asserting that it is the best available method for those cases where SLR is not applicable; these include narrow-focus search systems where a relevant knowledge base is unavailable. Our SLR method is also seen to outperform a state-of-the-art method in the task of diversified entity ranking. <br/

Gene by Disease Interaction on Orbitofrontal Gray Matter in Cocaine Addiction

Chronic cocaine use has been associated with structural deficits in brain regions having dopamine receptive neurons. However, the concomitant use of other drugs and common genetic variability in monoamine regulation present additional structural variability. We therefore examined variations in gray matter volume (GMV) as a function of lifetime drug use and the monoamine oxidase A (MAOA) genotype in cocaine use disorders (CUD) and healthy controls

Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma

<p>Abstract</p> <p>Background</p> <p>We previously found that administration of an interleukin 2/diphtheria toxin conjugate (DAB/IL2; Denileukin Diftitox; ONTAK) to stage IV melanoma patients depleted CD4⁺CD25^HIFoxp3⁺regulatory T cells and expanded melanoma-specific CD8⁺T cells. The goal of this study was to assess the clinical efficacy of DAB/IL2 in an expanded cohort of stage IV melanoma patients.</p> <p>Methods</p> <p>In a single-center, phase II trial, DAB/IL2 (12 μg/kg; 4 daily doses; 21 day cycles) was administered to 60 unresectable stage IV melanoma patients and response rates were assessed using a combination of 2-[¹⁸F]-fluoro-2-deoxy-glucose (FDG)-positron emission tomography (PET) and computed tomography (CT) imaging.</p> <p>Results</p> <p>After DAB/IL2 administration, 16.7% of the 60 patients had partial responses, 5% stable disease and 15% mixed responses. Importantly, 45.5% of the chemo/immuno-naïve sub-population (11/60 patients) experienced partial responses. One year survival was markedly higher in partial responders (80 ± 11.9%) relative to patients with progressive disease (23.7 ± 6.5%; <it>p </it>value < 0.001) and 40 ± 6.2% of the total DAB/IL2-treated population were alive at 1 year.</p> <p>Conclusions</p> <p>These data support the development of multi-center, randomized trials of DAB/IL2 as a monotherapy and in combination with other immunotherapeutic agents for the treatment of stage IV melanoma.</p> <p>Trial registration</p> <p><a href="http://www.clinicaltrials.gov/ct2/show/NCT00299689">NCT00299689</a></p

Sulforaphane Causes Epigenetic Repression of hTERT Expression in Human Breast Cancer Cell Lines

Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is a common dietary component that has histone deacetylase inhibition activity and exciting potential in cancer prevention. The mechanisms by which SFN imparts its chemopreventive properties are of considerable interest and little is known of its preventive potential for breast cancer. expression facilitated the induction of cellular apoptosis in human breast cancer cells.Collectively, our results provide novel insights into SFN-mediated epigenetic down-regulation of telomerase in breast cancer prevention and may open new avenues for approaches to SFN-mediated cancer prevention

Disrupted Functional Connectivity with Dopaminergic Midbrain in Cocaine Abusers

Background: Chronic cocaine use is associated with disrupted dopaminergic neurotransmission but how this disruption affects overall brain function (other than reward/motivation) is yet to be fully investigated. Here we test the hypothesis that cocaine addicted subjects will have disrupted functional connectivity between the midbrain (where dopamine neurons are located) and cortical and subcortical brain regions during the performance of a sustained attention task. Methodology/Principal Findings: We measured brain activation and functional connectivity with fMRI in 20 cocaine abusers and 20 matched controls. When compared to controls, cocaine abusers had lower positive functional connectivity of midbrain with thalamus, cerebellum, and rostral cingulate, and this was associated with decreased activation in thalamus and cerebellum and enhanced deactivation in rostral cingulate. Conclusions/Significance: These findings suggest that decreased functional connectivity of the midbrain interferes with the activation and deactivation signals associated with sustained attention in cocaine addicts