3 research outputs found

    Exploring the Therapeutic Potential of Rosemary: An In-depth Review of its Pharmacological Properties

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    The pharmacological effects of rosemary plant period a wide range and include anti-inflammatory and antioxidant properties. Rosemary is shown to have its potential on Ischemic stroke because of its Anti-oxidant and Anti-inflammatory properties. It contains strong antioxidants such carnosol, which has anti-inflammatory properties, and Rosmarinus acid, which fights oxidative stress. Rosemary is an attractive possibility for treating disorders like oxidative-related diseases because of its dual activity. Additionally, Rosemary has shown neuroprotective qualities that aid in maintaining brain health and cognitive function. The aromatic components in its essential oil may improve concentration and memory. Rosemary has also been investigated for its potential in hair care, with research indicating that it can encourage hair growth. These rosemary Officinalis also have different chemical substances and compounds like Terpenes, Essential oils, Bicyclic monoterpenes, Monoterpenoids, Ester and also, we have different pharmacological activates they are Anti-oxidative, Anti-inflammatory, Anti-microbial, Anti-obesity, Anti-fungal, Anti-cancer, Anti-diabetic, Cardiovascular activity, Skin health, Neuroprotective, Gastrointestinal, Sperm motility, Anti-depressant, Anti-viral activity

    Alleviating Ulcer Burdens Examining the Potential of Albizia Odoratissima Bark Extract as a Therapeutic Agent in Mice

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    Ulcerative stomach disease continues to be a prevalent gastrointestinal illness associated with high worldwide morbidity and medical costs. While nonsteroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori infection are well-known risk factors for the development of peptic ulcers, recent evidence suggests a complex interaction between host factors and the gut microbiota in ulcer etiology. This study provides a comprehensive review of recent research investigating the relationship between the genesis and progression of peptic ulcers and dysbiosis of the gut microbiota. The study highlights several natural compounds, such as flavonoids, polyphenols, alkaloids, and polysaccharides, that have demonstrated anti-ulcer activity in experimental models and clinical trials. Mechanistic understanding clarifies the many pathways, including antibacterial, anti-inflammatory, and antioxidant ones, through which these drugs perform their medicinal effects. It is interesting to note that many natural compounds focus on many pathogenic procedures that aid in the development and spread of ulcers, resulting in multifactorial effects. Albizia odoratissima is a member of the Fabaceae family and has been used traditionally in many folk medicines due to its medicinal characteristics. This study used experimental models of stomach ulceration to investigate potential anti-ulcer properties of methanolic bark extract from Albizia odoratissima (MAO). The anti-ulcer qualities of MAO were evaluated in rats using models of stomach ulceration brought on by HCL. Many parameters were assessed when different doses of MAO were administered orally, including the ulcer index, mucosal injury to the stomach, mucin content, and antioxidant enzyme levels. Additionally, a histological analysis was carried out to evaluate the possible protective qualities of MAO against harm to the stomach mucosa

    Zebrafish Heart: A Model for Cardiovascular Research and Regeneration

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    Zebrafish models are pivotal in cardiovascular research, offering a unique platform to study heart development, disease mechanisms, and potential therapies. Their transparent embryos and genetic manipulation tools, like CRISPR/Cas9, enable precise replication of human cardiac conditions such as heart failure, arrhythmias, and congenital defects. This accuracy is crucial for understanding disease pathways and testing new treatments effectively. These models simulate cardiac dysfunction through chemical disruptions, serving as robust platforms for drug discovery and testing. Their exceptional ability to regenerate heart tissue post-injury provides insights into treating human cardiovascular diseases. Various models, including surgical resection and genetic ablation, allow scientists to explore the mechanisms of cardiac regeneration, uncovering the roles of inflammation, cardiomyocyte dedifferentiation, and tissue reconstruction. Advanced imaging techniques like confocal microscopy offer detailed insights into cardiac dynamics, while electrophysiological recordings deepen the understanding of heart rhythms and abnormalities. High-throughput screening methods in zebrafish accelerate drug discovery efforts, aiding in the identification of potential treatments for diverse cardiovascular conditions. In essence, zebrafish models are invaluable tools for unraveling cardiovascular biology, clarifying disease pathways, and developing targeted therapies, with profound implications for improving cardiovascular disease management globally
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