Comments on the Monopole-Antimonopole Pair Solutions

Recently, the monopole-antimonopole pair and monopole-antimonopole chain solutions are solved with internal space coordinate system of $\theta$-winding number $m$ greater than one. However, we notice that it is also possible to solve these solutions numerically in terms of $\theta$-winding number $m=1$ instead. When $m=1$, the exact asymptotic solutions at small and large distances are parameterized by a single integer parameter $s$. Here we once again study the monopole-antimonopole pair solution of the SU(2) Yang-Mills-Higgs theory which belongs to the topological trivial sector numerically in its new form. This solution with $\theta$-winding and $\phi$-winding number one is parameterized by $s=0$ at small $r$ and $s=1$ at large $r$.Comment: Two figures, 13 pages, to be sent for publicatio

Decoherence of Einstein-Podolsky-Rosen steering

We consider two systems A and B that share Einstein-Podolsky-Rosen (EPR) steering correlations and study how these correlations will decay, when each of the systems are independently coupled to a reservoir. EPR steering is a directional form of entanglement, and the measure of steering can change depending on whether the system A is steered by B, or vice versa. First, we examine the decay of the steering correlations of the two-mode squeezed state. We find that if the system B is coupled to a reservoir, then the decoherence of the steering of A by B is particularly marked, to the extent that there is a sudden death of steering after a finite time. We find a different directional effect, if the reservoirs are thermally excited. Second, we study the decoherence of the steering of a Schr\"odinger cat state, modeled as the entangled state of a spin and harmonic oscillator, when the macroscopic system (the cat) is coupled to a reservoir

Half-Monopole and Multimonopole

We would like to present some exact SU(2) Yang-Mills-Higgs monopole solutions of half-integer topological charge. These solutions can be just an isolated half-monopole or a multimonopole with topological magnetic charge, ${1/2}m$, where $m$ is a natural number. These static monopole solutions satisfy the first order Bogomol'nyi equations. The axially symmetric one-half monopole gauge potentials possess a Dirac-like string singularity along the negative z-axis. The multimonopole gauge potentials are also singular along the z-axis and possess only mirror symmetries.Comment: 12 pages and 4 figures; typos corrected, reference adde

Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation

To identify rate-limiting steps in T cell-independent type 2 (TI-2) antibody production against polysaccharide antigens, we performed a genome-wide screen by immunizing several hundred pedigrees of C57BL/6 mice segregating ENU-induced mis-sense mutations. Two independent mutations, Tilcara and Untied, were isolated that semi-dominantly diminished antibody against polysaccharide but not protein antigens. Both mutations resulted from single amino acid substitutions within the kinase domain of Protein Kinase C Beta (PKCβ). In Tilcara, a Ser552>Pro mutation occurred in helix G, in close proximity to a docking site for the inhibitory N-terminal pseudosubstrate domain of the enzyme, resulting in almost complete loss of active, autophosphorylated PKCβI whereas the amount of alternatively spliced PKCβII protein was not markedly reduced. Circulating B cell subsets were normal and acute responses to BCR-stimulation such as CD25 induction and initiation of DNA synthesis were only measurably diminished in Tilcara homozygotes, whereas the fraction of cells that had divided multiple times was decreased to an intermediate degree in heterozygotes. These results, coupled with evidence of numerous mis-sense PRKCB mutations in the human genome, identify Prkcb as a genetically sensitive step likely to contribute substantially to population variability in anti-polysaccharide antibody levels

Decay and coherence of two-photon excited yellow ortho-excitons in Cu2O

Photoluminescence excitation spectroscopy has revealed a novel, highly efficient two-photon excitation method to produce a cold, uniformly distributed high density excitonic gas in bulk cuprous oxide. A study of the time evolution of the density, temperature and chemical potential of the exciton gas shows that the so called quantum saturation effect that prevents Bose-Einstein condensation of the ortho-exciton gas originates from an unfavorable ratio between the cooling and recombination rates. Oscillations observed in the temporal decay of the ortho-excitonic luminescence intensity are discussed in terms of polaritonic beating. We present the semiclassical description of polaritonic oscillations in linear and non-linear optical processes.Comment: 14 pages, 12 figure

OVERVIEW OF VIDEO DATA COLLECTION FOR 3-DIMENSIONAL MOTION ANALYSIS DURING THE FINAL ROUNDS OF THOMAS & UBER CUP 2000 BADMINTON CHAMPIONSHIPS

The aim of this paper is to report on the biomechanics project during the final rounds of Thomas & Uber Cup 2000 Badminton Championships. The results of three-dimensional analysis are also reported. To capture the data of world-class badminton players in competition, six synchronized video cameras were used to record video images at 50 field/second for 3-dimensional motion analysis during the Thomas & Uber Cup 2000 Badminton Championships in Malaysia. The semi-final and final matches were recorded. Some of the data was selected, analyzed and published in this paper

Hepatoprotective Activity of Dried- and Fermented-Processed Virgin Coconut Oil

The present study aims to determine the hepatoprotective effect of MARDI-produced virgin coconut oils, prepared by dried- or fermented-processed methods, using the paracetamol-induced liver damage in rats. Liver injury induced by 3 g/kg paracetamol increased the liver weight per 100 g bodyweight indicating liver damage. Histological observation also confirms liver damage indicated by the presence of inflammations and necrosis on the respective liver section. Interestingly, pretreatment of the rats with 10, but not 1 and 5, mL/kg of both VCOs significantly (P < .05) reduced the liver damage caused by the administration of paracetamol, which is further confirmed by the histological findings. In conclusion, VCO possessed hepatoprotective effect that requires further in-depth study

An immunotherapy survivor population: health-related quality of life and toxicity in patients with metastatic melanoma treated with immune checkpoint inhibitors

© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Purpose The immune checkpoint inhibitors (ICIs) have resulted in subgroups of patients with metastatic melanoma achievinghigh-quality durable responses. Metastatic melanoma survivors are a new population in the era of cancer survivorship. The aimofthis study was to evaluate metastatic melanoma survivors in terms of health-related quality of life (HRQoL), immune-relatedadverse events (irAEs) and exposure to immunosuppressive agents in a large single centre in the UK.Methods We defined the survivor population as patients with a diagnosis of metastatic melanoma who achieved a durableresponse to an ICI and had been followed-up for a minimum of 12 months from initiation of ICI without disease progression.HRQoL was assessed using SF-36. Electronic health records were accessed to collect data on demographics, treatments, irAEsand survival. HRQoL data was compared with two norm-based datasets.Results Eighty-four metastatic melanoma survivors were eligible and 87% (N = 73) completed the SF-36. ICI-related toxicity ofany grade occurred in 92%of patients and 43%had experienced a grade 3 or 4 toxicity. Almost half (49%) of the patients requiredsteroids for the treatment of ICI-related toxicity, whilst 14% required treatment with an immunosuppressive agent beyondsteroids.Melanoma survivors had statistically significant lower HRQoL scores with regard to physical, social and physical rolefunctioning and general health compared with the normative population. There was a trend towards inferior scores in patientswith previous exposure to ipilimumab compared with those never exposed to ipilimumab.Conclusions Our results show that metastatic melanoma survivors have potentially experienced significant ICI-related toxicityand experience significant impairments in specific HRQoL domains. Future service planning is required to meet this population’sunique survivorship needs.Peer reviewe

The 2011 Retrovirology Prize winner Masao Matsuoka: forward looking and antisense

Masao Matsuoka wins the 2011 Retrovirology Prize