Slotted Aloha for Optical Wireless Communications in Internet of Underwater Things

In this work, we design and analyse a Slotted ALOHA (SA) solution for Optical Wireless Communication (OWC)-based Internet of Underwater Things (IoUT). In the proposed system, user devices exchange data with an access point (AP) which exploits the capture effect. The space spanned by the IoUT nodes is three-dimensional, i.e., users are located in half-sphere centered at the AP placed at the bottom of a floating object at the water surface level. The analytical expressions for the system throughput and reliability expressed in terms of the outage probability are derived. Based on the simulated signal-to-noise-and-interference-ratio statistics and derived analytical expressions, we present numerical results that investigate the trade-off between the system performance and the IoUT system parameters, such as the number of users, activation probability and type of water medium. The presented conclusions provide valuable insights into the design of an SA-based solution for IoUT communications.Comment: Published in: 2023 32nd Wireless and Optical Communications Conference (WOCC

Attaching NorA efflux pump inhibitors to methylene blue enhances antimicrobial photodynamic inactivation of Escherichia coli and Acinetobacter baumannii in vitro and in vivo

Resistance of bacteria to antibiotics is a public health concern worldwide due to the increasing failure of standard antibiotic therapies. Antimicrobial photodynamic inactivation (aPDI) is a promising non-antibiotic alternative for treating localized bacterial infections that uses non-toxic photosensitizers and harmless visible light to produce reactive oxygen species and kill microbes. Phenothiazinium photosensitizers like methylene blue (MB) and toluidine blue O are hydrophobic cations that are naturally expelled from bacterial cells by multidrug efflux pumps, which reduces their effectiveness. We recently reported the discovery of a NorA efflux pump inhibitor-methylene blue (EPI-MB) hybrid compound INF55-(Ac)en-MB that shows enhanced photodynamic inactivation of the Gram-positive bacterium methicillin-resistant Staphylococcus aureus (MRSA) relative to MB, both in vitro and in vivo. Here, we report the surprising observation that INF55-(Ac)en-MB and two related hybrids bearing the NorA efflux pump inhibitors INF55 and INF271 also show enhanced aPDI activity in vitro (relative to MB) against the Gram-negative bacteria Escherichia coli and Acinetobacter baumannii, despite neither species expressing the NorA pump. Two of the hybrids showed superior effects to MB in murine aPDI infection models. The findings motivate wider exploration of aPDI with EPI-MB hybrids against Gram-negative pathogens and more detailed studies into the molecular mechanisms underpinning their activity

Multiple Access in the Era of Distributed Computing and Edge Intelligence

This paper focuses on the latest research and innovations in fundamental next-generation multiple access (NGMA) techniques and the coexistence with other key technologies for the sixth generation (6G) of wireless networks. In more detail, we first examine multi-access edge computing (MEC), which is critical to meeting the growing demand for data processing and computational capacity at the edge of the network, as well as network slicing. We then explore over-the-air (OTA) computing, which is considered to be an approach that provides fast and efficient computation of various functions. We also explore semantic communications, identified as an effective way to improve communication systems by focusing on the exchange of meaningful information, thus minimizing unnecessary data and increasing efficiency. The interrelationship between machine learning (ML) and multiple access technologies is also reviewed, with an emphasis on federated learning, federated distillation, split learning, reinforcement learning, and the development of ML-based multiple access protocols. Finally, the concept of digital twinning and its role in network management is discussed, highlighting how virtual replication of physical networks can lead to improvements in network efficiency and reliability

Systemic Mastocytosis

A 64-year-old man was admitted to the hematology ward due to neutropenia and thrombocytopenia. The only symptom in the month preceding his admission, was significant weight loss. Based on clinical and laboratory investigations, specifically bone marrow aspiration and biopsy, the patient was diagnosed with aggressive systemic mastocytosis (WHO 2008 ICD-0 code 9741/3)

Hemispheric symptoms and carotid plaque echomorphology

AbstractPurpose: In patients with carotid bifurcation disease, the risk of stroke mainly depends on the severity of the stenosis, the presenting hemispheric symptom, and, as recently suggested, on plaque echodensity. We tested the hypothesis that asymptomatic carotid plaques and plaques of patients who present with different hemispheric symptoms are related to different plaque structure in terms of echodensity and the degree of stenosis. Methods: Two hundred sixty-four patients with 295 carotid bifurcation plaques (146 symptomatic, 149 asymptomatic) causing more than 50% stenosis were examined with duplex scanning. Thirty-six plaques were associated with amaurosis fugax (AF), 68 plaques were associated with transient ischemic attacks (TIAs), and 42 plaques were associated with stroke. B-mode images were digitized and normalized using linear scaling and two reference points, blood and adventitia. The gray scale median (GSM) of blood was set to 0, and the GSM of the adventitia was set to 190 (gray scale range, black = 0; white = 255). The GSM of the plaque in the normalized image was used as the objective measurement of echodensity. Results: The mean GSM and the mean degree of stenosis, with 95% confidence intervals, for plaques associated with hemispheric symptoms were 13.3 (10.6 to 16) and 80.5 (78.3 to 82.7), respectively; and for asymptomatic plaques, the mean GSM and the mean degree of stenosis were 30.5 (26.2 to 34.7) and 72.2 (69.8 to 74.5), respectively. Furthermore, in plaques related to AF, the mean GSM and the mean degree of stenosis were 7.4 (1.9 to 12.9) and 85.6 (82 to 89.2), respectively; in those related to TIA, the mean GSM and the mean degree of stenosis were 14.9 (11.2 to 18.6) and 79.3 (76.1 to 82.4), respectively; and in those related to stroke, the mean GSM and the mean degree of stenosis were 15.8 (10.2 to 21.3) and 78.1 (73.4 to 82.8), respectively. Conclusion: Plaques associated with hemispheric symptoms are more hypoechoic and more stenotic than those associated with no symptoms. Plaques associated with AF are more hypoechoic and more stenotic than those associated with TIA or stroke or those without symptoms. Plaques causing TIA and stroke have the same echodensity and the same degree of stenosis. These findings confirm previous suggestions that hypoechoic plaques are more likely to be symptomatic than hyperechoic ones. They support the hypothesis that the pathophysiologic mechanism for AF is different from that for TIA and stroke. (J Vasc Surg 2000;31:39-49.