The NHS-HE Forum

This paper discusses the formation of the NHS-HE Forum by Professor Roland Rosner in 2001. It looks at the aims and objectives of the Forum and maps current progress. The second part of the paper looks particularly at the NHS-HE Procurement Group and the later JISC NHS-HE Procurement Group, which are part of the Forum. These groupings have been partially successful in conducting joint procurement activity across the NHS and HE sectors. The publication of Dr Ian Gibson?s Parliamentary Report Scientific Publications: Free for All? is seminal in progressing this joint activity. As of 1 February 2006, joint membership of the Public Library of Science has been achieved, but one joint procurement activity of commercial content has failed. Further joint procurement is planned, along with a mapping study of procurement activities and work on an Athens Account Linking Project. The library and informatics research components are coming to the fore with the use of a community-wide survey to establish the current situation and future plans for NHS-HE network connectivity and similarly the Mapping Study of Procurement Practices in the NHS and HE for content such as e-journals. This is moving to a more systematic approach than previously. The attempted joint procurement of selected journals has two joint aims: to support both research and clinical practice in the NHS and HE. This paper discusses the formation of the NHS-HE Forum by Professor Roland Rosner in 2001. It looks at the aims and objectives of the Forum and maps current progress. The second part of the paper looks particularly at the NHS-HE Procurement Group and the later JISC NHS-HE Procurement Group, which are part of the Forum. These groupings have been partially successful in conducting joint procurement activity across the NHS and HE sectors. The publication of Dr Ian Gibson?s Parliamentary Report Scientific Publications: Free for All? is seminal in progressing this joint activity. As of 1 February 2006, joint membership of the Public Library of Science has been achieved, but one joint procurement activity of commercial content has failed. Further joint procurement is planned, along with a mapping study of procurement activities and work on an Athens Account Linking Project. The library and informatics research components are coming to the fore with the use of a community-wide survey to establish the current situation and future plans for NHS-HE network connectivity and similarly the Mapping Study of Procurement Practices in the NHS and HE for content such as e-journals. This is moving to a more systematic approach than previously. The attempted joint procurement of selected journals has two joint aims: to support both research and clinical practice in the NHS and HE

Survival of Fecal Contamination Indicator Organisms in Soil

Soils amended with human or animal waste may result in pathogen contamination of ground and surface water. Because temperature has been shown to affect pathogen survival, two laboratory studies were conducted to evaluate the impact of extremes in temperature on bacterial and viral pathogen indicator die-off in soil. A Captina silt loam was amended with broiler litter (0.1 g/g dry soil), septic tank effluent, or Escherichia coli (ATCC 13706) culture (both at 0.04 and 0.1 mL/g dry soil in the two respective studies), incubated at 5 and 35°C, and analyzed over time to determine the number of fecal coliform, E. coli, and coliphage remaining. Pathogen indicator die-off rate constants (k) for all indicator- temperature-treatment combinations were determined by first-order kinetics. For all three pathogen indicators, die-off was significantly more rapid at 35°C than at 5°C. In both studies, fecal coliform die-off rates were not different from E. coli die-off rates across each temperature-treatment combination. Levels of these bacterial indicators appeared in a ratio of 1:0.94 with 95% confidence intervals at 0.89 and 0.99 in the E. coli- and litter-amended soils. Die-off of the viral indicator was significantly slower than the die-off of the bacterial indicators at 5°C in litter-amended soil. Die-off of the bacterial indicator, E. coli, in soil amended with E. coli culture was not significantly different than die-off in soil amended with broiler litter at 5 or 35°C in the two studies. Because the higher incubation temperature increased die-off rates for all three indicators, it is expected that the potential for contamination of ground and surface water decreases with increasing temperature

Measurement of a Sign-Changing Two-Gap Superconducting Phase in Electron-Doped Ba(Fe_{1-x}Co_x)_2As_2 Single Crystals using Scanning Tunneling Spectroscopy

Scanning tunneling spectroscopic studies of $Ba(Fe_{1-x}Co_x)_2As_2$ (x = 0.06, 0.12) single crystals reveal direct evidence for predominantly two-gap superconductivity. These gaps decrease with increasing temperature and vanish above the superconducting transition $T_c$. The two-gap nature and the slightly doping- and energy-dependent quasiparticle scattering interferences near the wave-vectors $(\pm \pi, 0)$ and $(0, \pm \pi)$ are consistent with sign-changing $s$-wave superconductivity. The excess zero-bias conductance and the large gap-to-$T_c$ ratios suggest dominant unitary impurity scattering.Comment: 4 pages, 4 figures. Paper accepted for publication in Physical Review Letters. Contact author: Nai-Chang Yeh ([email protected]

Scanning Tunneling Spectroscopic Studies of the Low-Energy Quasiparticle Excitations in Cuprate Superconductors

We report scanning tunneling spectroscopic (STS) studies of the low-energy quasiparticle excitations of cuprate superconductors as a function of magnetic field and doping level. Our studies suggest that the origin of the pseudogap (PG) is associated with competing orders (COs), and that the occurrence (absence) of PG above the superconducting (SC) transition T_c is associated with a CO energy Δ_(CO) larger (smaller) than the SC gap Δ_(SC). Moreover, the spatial homogeneity of Δ_(SC) and Δ_(CO) depends on the type of disorder in different cuprates: For optimally and under-doped YBa_2Cu_3O_(7−δ) (Y-123), we find that Δ_(SC) < Δ_(CO) and that both Δ_(SC) and Δ(CO) exhibit long-range spatial homogeneity, in contrast to the highly inhomogeneous STS in Bi_2Sr_2CaCu_2O_(8+x) (Bi-2212). We attribute this contrast to the stoichiometric cations and ordered apical oxygen in Y-123, which differs from the non-stoichiometric Bi-to-Sr ratio in Bi-2212 with disordered Sr and apical oxygen in the SrO planes. For Ca-doped Y-123, the substitution of Y by Ca contributes to excess holes and disorder in the CuO_2 planes, giving rise to increasing inhomogeneity, decreasing Δ_(SC) and Δ_(CO), and a suppressed vortex-solid phase. For electron-type cuprate Sr_(0.9)La_(0.1)CuO_2 (La-112), the homogeneous Δ_(SC) and Δ_(CO) distributions may be attributed to stoichiometric cations and the absence of apical oxygen, with Δ_(CO) < Δ_(SC) revealed only inside the vortex cores. Finally, the vortex-core radius (ξ_(halo)) in electron-type cuprates is comparable to the SC coherence length ξ_(SC), whereas ξ_(halo) ∼ 10ξ_(SC) in hole-type cuprates, suggesting that ξ_(halo) may be correlated with the CO strength. The vortex-state irreversibility line in the magnetic field versus temperature phase diagram also reveals doping dependence, indicating the relevance of competing orders to vortex pinning

Challenges and opportunities associated with neglected tropical disease and water, sanitation and hygiene intersectoral integration programs.

BACKGROUND: Recent research has suggested that water, sanitation, and hygiene (WASH) interventions, in addition to mass drug administration (MDA), are necessary for controlling and eliminating many neglected tropical diseases (NTDs). OBJECTIVES: This study investigated the integration of NTD and WASH programming in order to identify barriers to widespread integration and make recommendations about ideal conditions and best practices critical to future integrated programs. METHODS: Twenty-four in-depth, semi-structured interviews were conducted with key stakeholders in the global NTD and WASH sectors to identify barriers and ideal conditions in programmatic integration. RESULTS: The most frequently mentioned barriers to WASH and NTD integration included: 1) differing programmatic objectives in the two sectors, including different indicators and metrics; 2) a disproportionate focus on mass drug administration; 3) differences in the scale of funding; 4) siloed funding; and 5) a lack of coordination and information sharing between the two sectors. Participants also conveyed that a more holistic approach was needed if future integration efforts are to be scaled-up. The most commonly mentioned requisite conditions included: 1) education and advocacy; 2) development of joint indicators; 3) increased involvement at the ministerial level; 4) integrated strategy development; 5) creating task forces or committed partnerships; and 6) improved donor support. CONCLUSIONS: Public health practitioners planning to integrate NTD and WASH programs can apply these results to create conditions for more effective programs and mitigate barriers to success. Donor agencies should consider funding more integration efforts to further test the proof of principle, and additional support from national and local governments is recommended if integration efforts are to succeed. Intersectoral efforts that include the development of shared indicators and objectives are needed to foster conditions conducive to expanding effective integration programs