Efficient Termination of Spatially-Coupled Codes

Spatially-coupled low-density parity-check codes attract much attention due to their capacity-achieving performance and a memory-efficient sliding-window decoding algorithm. On the other hand, the encoder needs to solve large linear equations to terminate the encoding process. In this paper, we propose modified spatially-coupled codes. The modified (\dl,\dr,L) codes have less rate-loss, i.e., higher coding rate, and have the same threshold as (\dl,\dr,L) codes and are efficiently terminable by using an accumulator

Non-Binary LDPC Codes with Large Alphabet Size

We study LDPC codes for the channel with input ${x}\in \mathbb{F}_q^m$ and output ${y}={x}+{z}\in \mathbb{F}_q^m$. The aim of this paper is to evaluate decoding performance of $q^m$-ary non-binary LDPC codes for large $m$. We give density evolution and decoding performance evaluation for regular non-binary LDPC codes and spatially-coupled (SC) codes. We show the regular codes do not achieve the capacity of the channel while SC codes do

A Method for Estimating Physician Stress Using Wearable Sensor Devices

The idea of Society 5.0 initiative has been proposed to solve various social problems by connecting virtual cyberspace and real physical space through information technology. When applying the idea to improve the work-life balance of physicians in the medical field, we must consider the increased stress owing to their long continuous working hours. Estimating the stress of physicians in their daily lives by the questionnaires is insufficient, because of the difficulty of accurate their activity recalling. By using bio-metric information such as heart rate, physical activity, and sleeping information, it was expected that the daily stress state of physicians with high accuracy. In this paper, we propose a method for estimating physician stress by analyzing bio-metric information acquired by wearing a wearable sensor device. The proposed method estimates the state of stress during daily activities by acquiring data on heart rate variability (HRV) during wakefulness as well as sleep depth during rapid eye movement (REM) and non-REM sleep. Up to seven physicians wore the wearable sensor device for the maximum of eight weeks and the sleep depth and low-/high-frequency (LF/HF) components of HRV were obtained. Our observation showed that physicians' root mean square of successive differences (rMSSDs) were constantly high in their healthy state. Therefore, the decreasing of this index can be used as an indicator of fatigue and stress. In addition, by combining LF/HF components to the rMSSDs, we may estimate the stress state of physicians and find personal stressors

Effects of oral administration of S-1 on the pharmacokinetics of SN-38, irinotecan active metabolite, in patients with advanced colorectal cancer

Previous studies have assessed the efficacy and safety of combined treatment with irinotecan (7-ethyl-10-[4-[1-piperidino]-1-piperidino]carbonyloxycamptothecin, CPT-11) and S-1, containing tegafur, a prodrug of 5-fluorouracil, in the treatment of colorectal and gastric cancer. The objective of this study was to describe the interaction between CPT-11 and S-1 in 4 patients with colorectal cancer. Coadministration of S-1 changed the pharmacokinetic behavior of CPT-11 and its metabolites. In particular, maximum plasma concentration (Cmax) and area under the plasma concentration curve (AUC) of 7-ethyl-10-hydroxycampothecin (SN-38) was markedly decreased by coadministration of S-1. For SN-38, the median ratio of Cmax and AUC with S-1 to those without S-1 was median 0.34 (range 0.24-0.78) and 0.56 (range 0.23-0.68), respectively. A markedly difference in drug interaction among individual patients was observed. We conclude that the plasma concentration of SN-38 was decreased by oral administration of S-1 in patients with colorectal cancer. This observation might be important for clinical decisions regarding combination therapy