2,909 research outputs found
Economically Feasible Crop Production Alternatives to Peanuts in Southwestern Oklahoma
Get PDFChanges in the U.S. peanut program have resulted in drastically decreased planted acres and forced many peanut producers in the Southwest to consider alternative crops. This study examined the economic risk associated with producing peanuts and common alternatives to peanuts. Seedless watermelon is an alternative for risk preferring farmers whereas, irrigated peanut is the best choice for risk averse farmers.Crop Production/Industries,
Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems
Get PDFConstitutive activation of the Notch pathway can promote gliogenesis by peripheral (PNS) and central (CNS) nervous system progenitors. This raises the question of whether physiological Notch signaling regulates gliogenesis in vivo. To test this, we conditionally deleted Rbpsuh (Rbpj) from mouse PNS or CNS progenitors using Wnt1-Cre or Nestin-Cre. Rbpsuh encodes a DNAbinding protein (RBP/J) that is required for canonical signaling by all Notch receptors. In most regions of the developing PNS and spinal cord, Rbpsuh deletion caused only mild defects in neurogenesis, but severe defects in gliogenesis. These resulted from defects in glial specification or differentiation, not premature depletion of neural progenitors, because we were able to culture undifferentiated progenitors from the PNS and spinal cord despite their failure to form glia in vivo. In spinal cord progenitors, Rbpsuh was required to maintain Sox9 expression during gliogenesis, demonstrating that Notch signaling promotes the expression of a glial-specification gene. These results demonstrate that physiological Notch signaling is required for gliogenesis in vivo, independent of the role of Notch in the maintenance of undifferentiated neural progenitors
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