Estimation of 511 keV gamma scatter fraction in WLS layer in total-body J-PET : a simulation study

Positron emission tomography (PET) is essential in medical diagnostics and monitoring therapy. The J-PET Collaboration at Jagiellonian University is developing a new generation of Total-Body PET scanners based on plastic scintillators. One of the Total-Body J-PET designs comprises seven rings, each consisting of 24 modules. A single module is built of 2 layers, each comprises of 16 axially arranged plastic scintillator strips of 330 mm length, read out by silicon photomultiplier (SiPM) arrays from both ends, and an additional layer of 50 wavelength shifter (WLS) bars, placed perpendicular to plastic layers. This study estimates the scatter fraction of the Total-Body J-PET manufactured from plastic scintillator strips according to the NEMA NU 2-2018 standards by using the GATE software. The scatter phantom was simulated as a solid cylinder with a length of 700 mm and an outside diameter equal to 203 mm. At the same time, at a radial distance of 45 mm, we have a hole with a diameter of 6.4 mm where a linear source with total activity of 1 MBq is placed. For data processing, sinograms were generated, and the Single Slice Rebinning (SSRB) algorithm was used for the scatter fraction calculation. As a result, we estimate that addition of the WLS layer is increasing the scatter fraction by 0.67%

ProTheRaMon : a GATE simulation framework for proton therapy range monitoring using PET imaging

Objective. This paper reports on the implementation and shows examples of the use of the ProTheRaMon framework for simulating the delivery of proton therapy treatment plans and range monitoring using positron emission tomography (PET). ProTheRaMon offers complete processing of proton therapy treatment plans, patient CT geometries, and intra-treatment PET imaging, taking into account therapy and imaging coordinate systems and activity decay during the PET imaging protocol specific to a given proton therapy facility. We present the ProTheRaMon framework and illustrate its potential use case and data processing steps for a patient treated at the Cyclotron Centre Bronowice (CCB) proton therapy center in Krakow, Poland. Approach. The ProTheRaMon framework is based on GATE Monte Carlo software, the CASToR reconstruction package and in-house developed Python and bash scripts. The framework consists of five separated simulation and data processing steps, that can be further optimized according to the user’s needs and specific settings of a given proton therapy facility and PET scanner design. Main results. ProTheRaMon is presented using example data from a patient treated at CCB and the J-PET scanner to demonstrate the application of the framework for proton therapy range monitoring. The output of each simulation and data processing stage is described and visualized. Significance. We demonstrate that the ProTheRaMon simulation platform is a high-performance tool, capable of running on a computational cluster and suitable for multi-parameter studies, with databases consisting of large number of patients, as well as different PET scanner geometries and settings for range monitoring in a clinical environment. Due to its modular structure, the ProTheRaMon framework can be adjusted for different proton therapy centers and/or different PET detector geometries. It is available to the community via github (Borys et al 2022)