Nanoparticles in optic nerve trauma: nanoscaffolding, visualization and regeneration

Session 1 - Nanotechnology / Vision Restoration: Concepts, Possibilities, Challengespostprin

Nanoscale technologies: nano-knitting, healing powers and hemostasis

Session 2 - Nanotechnology / Vision Restoration: Clinical Usespostprin

Nano hemostat solution: immediate hemostasis at the nanoscale

Hemostasis is a major problem in surgical procedures and after major trauma. There are few effective methods to stop bleeding without causing secondary damage. We used a self-assembling peptide that establishes a nanofiber barrier to achieve complete hemostasis immediately when applied directly to a wound in the brain, spinal cord, femoral artery, liver, or skin of mammals. This novel therapy stops bleeding without the use of pressure, cauterization, vasoconstriction, coagulation, or cross-linked adhesives. The self-assembling solution is nontoxic and nonimmunogenic, and the breakdown products are amino acids, which are tissue building blocks that can be used to repair the site of injury. Here we report the first use of nanotechnology to achieve complete hemostasis in less than 15 seconds, which could fundamentally change how much blood is needed during surgery of the future. © 2006.postprin

Forever young: How to control the elongation, differentiation, and proliferation of cells using nanotechnology

Within the emerging field of stem cells there is a need for an environment that can regulate cell activity, to slow down differentiation or proliferation, in vitro or in vivo while remaining invisible to the immune system. By creating a nanoenvironment surrounding PC12 cells, Schwann cells, and neural precursor cells (NPCs), we were able to control the proliferation, elongation, differentiation, and maturation in vitro. We extended the method, using self-assembling nanofiber scaffold (SAPNS), to living animals with implants in the brain and spinal cord. Here we show that when cells are placed in a defined system we can delay their proliferation, differentiation, and maturation depending on the density of the cell population, density of the matrix, and the local environment. A combination of SAPNS and young cells can be implanted into the central nervous system (CNS), eliminating the need for immunosuppressants. Copyright © 2009 Cognizant Comm. Corp.published_or_final_versio

The effect of peripheral nerve graft on the axonal regeneration of pyramidal neurons in hamsters following proximal or distal axotomy

Neuroscience Letters. Supplement, 1994, v. 45, p. S6

Morphological studies of nitric oxide synthase in hamster retina

Acta Physiologica Scandinavia, 1999, v. 167 n.2 - Proceedings of the Scandinavian Physiological Society meeting in Umea, 28-30 May 1999