Effects of LatticeQCD EoS and Continuous Emission on Some ObseErvables

Effects of lattice-QCD-inspired equations of state and continuous emission on some observables are discussed, by solving a 3D hydrodynamics. The particle multiplicity as well as v2 are found to increase in the mid-rapidity. We also discuss the effects of the initial-condition fluctuations.Comment: 6 pages, 10 figures, prepared for Workshop on Particle Correlations and Fentoscopy, Kromeriz (Czech Republic), Aug. 15-17,200

NeXSPheRIO results on elliptic flow at RHIC and connection with thermalization

Elliptic flow at RHIC is computed event-by-event with NeXSPheRIO. Reasonable agreement with experimental results on $v_2(\eta)$ is obtained. Various effects are studied as well: reconstruction of impact parameter direction, freeze out temperature, equation of state (with or without crossover), emission mecanism.Comment: Contribution to the Proceedings of the Quark-Gluon Plasma Thermalization workshop. Content slightly increase

Disruption of ph dynamics suppresses proliferation and potentiates doxorubicin cytotoxicity in breast cancer cells

The reverse pH gradient is a major feature associated with cancer cell reprogrammed metabolism. This phenotype is supported by increased activity of pH regulators like ATPases, carbonic anhydrases (CAs), monocarboxylate transporters (MCTs) and sodium–proton exchangers (NHEs) that induce an acidic tumor microenvironment, responsible for the cancer acid-resistant phenotype. In this work, we analyzed the expression of these pH regulators and explored their inhibition in breast cancer cells as a strategy to enhance the sensitivity to chemotherapy. Expression of the different pH regulators was evaluated by immunofluorescence and Western blot in two breast cancer cell lines (MDA-MB-231 and MCF-7) and by immunohistochemistry in human breast cancer tissues. Cell viability, migration and invasion were evaluated upon exposure to the pH regulator inhibitors (PRIs) concanamycin-A, cariporide, acetazolamide and cyano-4-hydroxycinnamate. Additionally, PRIs were combined with doxorubicin to analyze the effect of cell pH dynamic disruption on doxorubicin sensitivity. Both cancer cell lines expressed all pH regulators, except for MCT1 and CAXII, only expressed in MCF-7 cells. There was higher plasma membrane expression of the pH regulators in human breast cancer tissues than in normal breast epithelium. Additionally, pH regulator expression was significantly associated with different molecular subtypes of breast cancer. pH regulator inhibition decreased cancer cell aggressiveness, with a higher effect in MDA-MB-231. A synergistic inhibitory effect was observed when PRIs were combined with doxorubicin in the breast cancer cell line viability. Our results support proton dynamic disruption as a breast cancer antitumor strategy and the use of PRIs to boost the activity of conventional therapy.This research was funded by National funds, through the Foundation for Science and Technology (FCT) - project UIDB/50026/2020 and UIDP/50026/2020; and by the projects NORTE-01-0145-FEDER-000013 and NORTE-01-0145-FEDER-000023, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). This work was also supported by an internal CESPU project MetabRes_CESPU_2017. DT-V received a fellowship from FCT (ref. SFRH/BD/103025/2014)

Spatial distribution, host specificity, and affinity of Branchiura for surface and macrohabitat types in fish species from the Brazilian Amazon.

This study investigated the spatial distribution, parasite interactions, and affinities of Branchiura parasites according to macrohabitat and surface type on fish from the Araguari River, Amapá State, in the Brazilian Amazon. This study presents novel information on the interactions of branchiuran species with host fish, and how the morphology of their attachment structures is associated with different host surface morphologies, with and without scales. A total of 558 fish specimens of 26 species were collected, of which 109 fish (10 species) were parasitized by at least one branchiuran parasite; these were selected for further study. The parasites were collected from the buccal cavity, gills, fins, and integument of the host fish. Parasites with suction discs (Argulus) were mainly associated to hosts with small scales and no scales, while parasites with hooks (Dolops) were mainly associated to hosts with large scales. Overall, parasites with suction discs were more specialized per site than those with hooks

O arranjo produtivo local (APL) do açaí na Ilha de Arumanduba (Abaetetuba/PA): um estudo de caso na comunidade Nossa Senhora da Paz.

O artigo discute o arranjo produtivo local (APL) do açaí na ilha de Arumanduba no município de Abaetetuba/PA. São analisados os principais aspectos da extração com base na cadeia produtiva e na potencialização do fruto para o desenvolvimento local gerado pelo manejo e comercialização do açaí. Ressalta-se ainda a importância da atividade para a comunidade Nossa Senhora da Paz e as principais características da produção, observando suas particularidades. O trabalho apresenta também a cadeia produtiva do açaí na região, tal atividade agrega para a agricultura familiar oportunidades de geração de renda através do fruto durante todo o ano, comercializando a matéria prima do açaizeiro, originando subprodutos para o comércio local e adjacências. Por fim, o artigo destaca que a atividade, além de satisfazer as necessidades econômicas e sociais dos agricultores locais, estes acabam permanecendo em suas propriedades