4 research outputs found
The Gelatinase BiosynthesisâActivating Pheromone binds and stabilizes the FsrB membrane protein in Enterococcus faecalis quorum sensing
Quorumâsensing mechanisms regulate gene expression in response to changing cellâpopulation density detected through pheromones. In Enterococcus faecalis, Fsr quorum sensing produces and responds to the gelatinase biosynthesisâactivating pheromone (GBAP). Here we establish that the enterococcal FsrB membrane protein has a direct role connected with GBAP by showing that GBAP binds to purified FsrB. FarâUV CD measurements demonstrated a predominantly αâhelical protein exhibiting a small level of conformational flexibility. Fivefold (400 ÎŒm) GBAP stabilised FsrB (80 ÎŒm) secondary structure. FsrB thermal denaturation in the presence and absence of GBAP revealed melting temperatures of 70.1 and 60.8 °C, respectively, demonstrating GBAP interactions and increased thermal stability conferred by GBAP. Addition of GBAP also resulted in tertiary structural changes, confirming GBAP binding
HHIPL1, a Gene at the 14q32 Coronary Artery Disease Locus, Positively Regulates Hedgehog Signaling and Promotes Atherosclerosis
The research leading to these results has received funding from the European Union Seventh Framework Programme FP7/2007â2013 under grant agreement number HEALTH-F2-2013â601456, a Transatlantic Networks of Excellence Award (12CVD02) from The Leducq Foundation and the British Heart Foundation (SP/18/8/33620) as a partner of the European Research Area Network on Cardiovascular Diseases (ERA-CVD) druggable-MI-genes (01KL1802) and supported by the UK National Institute for Health Research (NIHR) Leicester Biomedical Research Centre. Dr Samani is a UK NIHR Senior Investigator. Drs Morris, Ye, and Webb are funded by the British Heart Foundation (SP/16/4/32697).Peer reviewedPublisher PD
Gray matter volume covariance patterns associated with gait speed in older adults: a multi-cohort MRI study
Teaching Bioeconomics
Bioeconomics is a relatively young field that uses an expanded microeconomics to examine animal behavior, human behavior, and animal and human social institutions. A voluminous literature is rapidly accumulating. There are as yet no standard textbooks, but there are several excellent books and/or articles that can be used in combination with videos and other aids to make a course that students will enjoy and that teachers can use to advance the frontiers of scholarship in economics and biology. Copyright Springer 2005altruism, conflict, cooperation, evolution, game theory, institutions, rationality,