Terwilliger Algebras of Cyclotomic Schemes and Jacobi Sums

AbstractWe show that theT-module structure of a cyclotomic scheme is described in term of Jacobi sums. It holds that an irreducibleT-module of a cyclotomic scheme fails to have maximal dimension if and only if Jacobi sums satisfy certain kind of equations, which are of some number theoretical interest in themselves

Sacral Fracture Causing Neurogenic Bladder: A Case Report

A 76-year-old man presented with a Denis Zone III sacral fracture after a traffic accident. He also developed urinary retention and perineal numbness. The patient was diagnosed with neurogenic bladder dysfunction caused by the sacral fracture. A computed tomogram (CT) revealed that third sacral lamina was fractured and displaced into the spinal canal, but vertebral body did not displace. The fracture lines began at the center of lamina and extended bilateraly. The fracture pattern was unique. The sacrum was osteoporosis, and this fracture may be based on osteoporosis. We performed laminectomy to decompress sacral nerve roots. One month after surgery, the patient was able to urinate. Three months after surgery, his bladder function recovered normally. One year after surgery, he returned to a normal daily life and had no complaints regarding urination. One-year postoperative CT showed the decompressed third sacrum without displacement

The Specific Sagittal Magnetic Resonance Imaging of Intradural Extra-Arachnoid Lumbar Disc Herniation

Intradural extra-arachnoid lumbar disc herniation is a rare disease. Few MRI findings have been reported. We experienced an intradural extra-arachnoid lumbar disc herniation. We reviewed the preoperative MRI findings. Lumbar spine T2-weighted sagittal MRI showed that one line of the ventral dura was divided into two by a disc herniation. We speculated that the two lines comprised the dura and arachnoid and that a disc herniation existed between them. We believe that division of the ventral dural line on T2-weighted sagittal images is a characteristic finding of intradural extra-arachnoid lumbar disc herniation. The division of ventral dural line seemed to be a “Y,” and, thus, we called it the “Y sign.” The “Y sign” may be useful for diagnosing intradural extra-arachnoid lumbar disc herniation

A preliminary study of a cloth guiding mechanism for automatic sewing system

Purpose - In the trend from mass production to mass customization, more flexible production systems are required. In the clothing field, many studies about automatization of sewing processes have been done into producing small amounts of various kinds of products. The purpose of this paper is to propose a versatile guiding mechanism of a cloth for an automatic sewing system. Design/methodology/approach - Real sewing processes were referenced for the mechanism, and curved stitch is formed holding a point on a cloth. This mechanism consists of a solenoid for holding a cloth and a roller to prevent deformation of the cloth. When a cloth is sewn with the mechanism, the trajectory of the stitch is unstable because of anisotropy of a cloth. A precise trajectory was obtained by adding a device to control the pressure of the roller for holding a cloth and keeping a tension properly applied to a cloth. Findings - It was found out that shearing property is the most related to the stability of sewing trajectory: lithe tension for guidance applied to a cloth is constant, deformation of the cloth was observed and it was the cause of unstableness of sewing trajectory. By controlling the tension for guidance applied to a cloth properly according to the direction of the cloth, precise sewing trajectory was obtained. Originality/value - There have been some studies in which sewing conditions were dynamically controlled according to the mechanical properties of a cloth. To these studies, here it was proposed that sewing conditions were kept constant by controlling the guidance of a cloth according to its mechanical properties.ArticleINTERNATIONAL JOURNAL OF CLOTHING SCIENCE AND TECHNOLOGY. 24(1):6-14 (2012)journal articl

Deep Predictive Learning: Motion Learning Concept inspired by Cognitive Robotics

Bridging the gap between motion models and reality is crucial by using limited data to deploy robots in the real world. Deep learning is expected to be generalized to diverse situations while reducing feature design costs through end-to-end learning for environmental recognition and motion generation. However, data collection for model training is costly, and time and human resources are essential for robot trial-and-error with physical contact. We propose "Deep Predictive Learning," a motion learning concept that predicts the robot's sensorimotor dynamics, assuming imperfections in the prediction model. The predictive coding theory inspires this concept to solve the above problems. It is based on the fundamental strategy of predicting the near-future sensorimotor states of robots and online minimization of the prediction error between the real world and the model. Based on the acquired sensor information, the robot can adjust its behavior in real time, thereby tolerating the difference between the learning experience and reality. Additionally, the robot was expected to perform a wide range of tasks by combining the motion dynamics embedded in the model. This paper describes the proposed concept, its implementation, and examples of its applications in real robots. The code and documents are available at: https://ogata-lab.github.io/eipl-doc

Data-driven identification and classification of nonlinear aging patterns reveals the landscape of associations between DNA methylation and aging

オミックスデータから非線形な加齢変化の全体像を取得する解析手法を開発. 京都大学プレスリリース. 2023-02-13.[Background] Aging affects the incidence of diseases such as cancer and dementia, so the development of biomarkers for aging is an important research topic in medical science. While such biomarkers have been mainly identified based on the assumption of a linear relationship between phenotypic parameters, including molecular markers, and chronological age, numerous nonlinear changes between markers and aging have been identified. However, the overall landscape of the patterns in nonlinear changes that exist in aging is unknown. [Result] We propose a novel computational method, Data-driven Identification and Classification of Nonlinear Aging Patterns (DICNAP), that is based on functional data analysis to identify biomarkers for aging and potential patterns of change during aging in a data-driven manner. We applied the proposed method to large-scale, public DNA methylation data to explore the potential patterns of age-related changes in methylation intensity. The results showed that not only linear, but also nonlinear changes in DNA methylation patterns exist. A monotonous demethylation pattern during aging, with its rate decreasing at around age 60, was identified as the candidate stable nonlinear pattern. We also analyzed the age-related changes in methylation variability. The results showed that the variability of methylation intensity tends to increase with age at age-associated sites. The representative variability pattern is a monotonically increasing pattern that accelerates after middle age. [Conclusion] DICNAP was able to identify the potential patterns of the changes in the landscape of DNA methylation during aging. It contributes to an improvement in our theoretical understanding of the aging process

Effect of enhanced expression of connexin 43 on sunitinib-induced cytotoxicity in mesothelioma cells

AbstractConnexin (Cx) makes up a type of intercellular channel called gap junction (GJ). GJ plays a regulatory role in cellular physiology. The Cx expression level is often decreased in cancer cells compared to that in healthy ones, and the restoration of its expression has been shown to exert antiproliferative effects. This work aims to evaluate the effect of the restoration of connexin 43 (Cx43) (the most ubiquitous Cx subtype) expression on sunitinib (SU)-induced cytotoxicity in malignant mesothelioma (MM) cells. Increased Cx43 expression in an MM cell line (H28) improved the ability of SU to inhibit receptor tyrosine kinase (RTK) signaling. Moreover, higher Cx43 expression promoted SU-induced apoptosis. The cell viability test revealed that Cx43 enhanced the cytotoxic effect of SU in a GJ-independent manner. The effect of Cx43 on a proapoptotic factor, Bax, was then investigated. The interaction between Cx43 and Bax was confirmed by immunoprecipitation. Furthermore, higher Cx43 expression increased the production of a cleaved (active) form of Bax during SU-induced apoptosis with no alteration in total Bax expression. These findings indicate that Cx43 most likely increases sensitivity to SU in H28 through direct interaction with Bax. In conclusion, we found that Cx43 overcame the chemoresistance of MM cells

Learning of Language Grounding in Robot Behavior by Recurrent Neural Networks

早稲田大学博士(工学)早大学位記番号:新8122doctoral thesi

Unusual Protrusion of Conjunctiva in Two Neonates with Harlequin Ichthyosis

Background: We present two patients who developed severe protrusion of the conjunctiva and chemosis secondary to Harlequin ichthyosis (HI). Case Reports: Case 1 was a male infant diagnosed with HI who had parchment-like appearance and conjunctival protrusion with severe chemosis. Case 2 was a female infant on whom HI had been suspected before birth through ultrasonography. She showed thickened skin over the entire body and conjunctival protrusion with severe chemosis. For both cases, a vitamin A derivative was applied and the hyperkeratotic layer was peeled off every day. Great care was taken to sterilize and moisten the ocular surface. The conjunctival protrusion gradually improved and other systemic conditions were successfully treated. HI is a rare condition, but affected infants are surviving longer than previously and hence guidelines for ocular management are now required. Conclusions: Gentle and patient debridement of the hyperkeratotic skin and moisturizing were important in treating the unusual conjunctival protrusion

Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG

Nectins, Ca2+-independent immunoglobulin-like cell–cell adhesion molecules, initiate cell–cell adhesion by their trans interactions and recruit cadherins to cooperatively form adherens junctions (AJs). In addition, the trans interactions of nectins induce the activation of Cdc42 and Rac small G proteins, which increases the velocity of the formation of AJs. We examined here how nectins induce the activation of Cdc42 in MDCK epithelial cells and L fibroblasts. Nectins recruited and activated c-Src at the nectin-based cell–cell adhesion sites. FRG, a GDP/GTP exchange factor specific for Cdc42, was then recruited there, tyrosine phosphorylated by c-Src, and activated, causing an increase in the GTP-bound active form of Cdc42. Inhibition of the nectin-induced activation of c-Src suppressed the nectin-induced activation of FRG and Cdc42. Inhibition of the nectin-induced activation of FRG or depletion of FRG by RNA interference suppressed the nectin-induced activation of Cdc42. These results indicate that nectins induce the activation of Cdc42 through c-Src and FRG locally at the nectin-based cell–cell adhesion sites