22 research outputs found
Sample Size Effect of Magnetomechanical Response for Magnetic Elastomers by Using Permanent Magnets
The size effect of magnetomechanical response of chemically cross-linked disk shaped magnetic elastomers placed on a permanent magnet has been investigated by unidirectional compression tests. A cylindrical permanent magnet with a size of 35鈥塵m in diameter and 15鈥塵m in height was used to create the magnetic field. The magnetic field strength was approximately 420鈥塵T at the center of the upper surface of the magnet. The diameter of the magnetoelastic polymer disks was varied from 14鈥塵m to 35鈥塵m, whereas the height was kept constant (5鈥塵m) in the undeformed state. We have studied the influence of the disk diameter on the stress-strain behavior of the magnetoelastic in the presence and in the lack of magnetic field. It was found that the smallest magnetic elastomer with 14鈥塵m diameter did not exhibit measurable magnetomechanical response due to magnetic field. On the opposite, the magnetic elastomers with diameters larger than 30鈥塵m contracted in the direction parallel to the mechanical stress and largely elongated in the perpendicular direction. An explanation is put forward to interpret this size-dependent behavior by taking into account the nonuniform field distribution of magnetic field produced by the permanent magnet
Variantes gen茅ticas en el locus 9p21 contribuyen al desarrollo de arteriosclerosis a trav茅s de la modulaci贸n de ANRIL y CDKN2A/B
Registro creado en correspondencia al grado de doctora de Ada Congrains Castillo.Los estudios de asociaci贸n de todo el genoma (GWAS) han identificado variantes gen茅ticas que contribuyen al riesgo de enfermedad cardiovascular (ECV) en el locus del cromosoma 9p21. La regi贸n asociada a CVD es adyacente a los dos inhibidores de quinasas dependientes de ciclina (CDKN) 2A y 2B y los 煤ltimos exones del ARN no codificante, ANRIL. Todav铆a no est谩 claro cu谩l de estas transcripciones o c贸mo est谩n involucradas en la patog茅nesis de la aterosclerosis.Genome-wide association studies (GWAS) have identified genetic variants contributing to the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The CVD-associated region is adjacent to the two cyclin dependent kinase inhibitors (CDKN)2A and 2B and the last exons of the non-coding RNA, ANRIL. It is still not clear which of or how these transcripts are involved in the pathogenesis of atherosclerosis.Jap贸n. Programa de Promoci贸n de Estudios Fundamentales en el Instituto Nacional de Innovaci贸n Biom茅dica de Jap贸n
(HR: 22-2-5), el Ministerio de Educaci贸n, Cultura, Deportes, Ciencia y Tecnolog铆a de
Jap贸n (KK: 22510211) y la Fundaci贸n NOVARTIS para la Investigaci贸n Gerontol贸gica (KK).Tesi
Loss of ACE2 Exaggerates High-Calorie Diet鈥揑nduced Insulin Resistance by Reduction of GLUT4 in Mice
A protocol for preparation of chromosome spread and processing for transmission electron microscopy
Transmission electron microscopic (TEM) observation of human chromosome ultrastructure may provide useful information on various abnormalities. Due to the difficulties in detaching metaphase chromosome spreads from the glass slide, this approach has been restricted. We introduce a simplified protocol in which the metaphase chromosome spreads are made on a flexible thermoplastic membrane (Aclar film) glued to the routine microscopic glass slides. The chromosome spreads are then impregnated with 1% osmium tetroxide, stained with freshly prepared 2% tannic acid, dehydrated, and flat-embedded in epoxy resin. After polymerization, the epoxy resin sheet is easily detached from the Aclar film and all chromosome spreads retain on the resin sheet. Each chromosome spread is identified under a light microscope, demarcated, trimmed then attached to a pre-polymerized blank epoxy resin block. Ultrathin sections are cut and observed under a transmission electron microscope. Application of this method to chromosome research is suggested to provide useful information on the chromosome morphology and ultrastructure in relation to various conditions and/or function.</p
In situ Search for Breast Cancer Stem Cells and Their Niche: The Film Sheet Epoxy Resin Embedding Method and Breast Cancer Stem Cells
Immunohistochemical Localization of CA 125 Antigen in Formalin-Fixed Paraffin Sections of Ovarian Tumors with the Use of Pronase庐
Characteristics of histopathological and ultrastructural features of placental villi in pregnant Nepalese women
Variantes gen茅ticas en el locus 9p21 contribuyen al desarrollo de arteriosclerosis a trav茅s de la modulaci贸n de ANRIL y CDKN2A/B
Registro creado en correspondencia al grado de doctora de Ada Congrains Castillo.Los estudios de asociaci贸n de todo el genoma (GWAS) han identificado variantes gen茅ticas que contribuyen al riesgo de enfermedad cardiovascular (ECV) en el locus del cromosoma 9p21. La regi贸n asociada a CVD es adyacente a los dos inhibidores de quinasas dependientes de ciclina (CDKN) 2A y 2B y los 煤ltimos exones del ARN no codificante, ANRIL. Todav铆a no est谩 claro cu谩l de estas transcripciones o c贸mo est谩n involucradas en la patog茅nesis de la aterosclerosis.Genome-wide association studies (GWAS) have identified genetic variants contributing to the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The CVD-associated region is adjacent to the two cyclin dependent kinase inhibitors (CDKN)2A and 2B and the last exons of the non-coding RNA, ANRIL. It is still not clear which of or how these transcripts are involved in the pathogenesis of atherosclerosis.Este estudio fue apoyado en parte por subvenciones en ayuda del Programa de Promoci贸n
de Estudios Fundamentales en el Instituto Nacional de Innovaci贸n Biom茅dica de Jap贸n
(HR: 22-2-5), el Ministerio de Educaci贸n, Cultura, Deportes, Ciencia y Tecnolog铆a de
Jap贸n (KK: 22510211) y la Fundaci贸n NOVARTIS para la Investigaci贸n Gerontol贸gica (KK).Tesi