On relativization of the Sommerfeld-Gamow-Sakharov factor

The Sommerfeld-Gamow-Sakharov factor is considered for the general case of arbitrary masses and energies. It is shown that the scalar triangular one-loop diagram gives the Coulomb singularity in radiative corrections at the threshold. The singular part of the correction is factorized at the complete Born cross section regardless of its partial wave decomposition. Different approaches to generalize the factor are discussed.Comment: 9 pages, 4 figures; references and discussion are extende

α-Conotoxins and α-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells

Among the brain tumors, glioma is the most common. In general, different biochemical mechanisms, involving nicotinic acetylcholine receptors (nAChRs) and the arachidonic acid cascade are involved in oncogenesis. Although the engagement of the latter in survival and proliferation of rat C6 glioma has been shown, there are practically no data about the presence and the role of nAChRs in C6 cells. In this work we studied the effects of nAChR antagonists, marine snail α-conotoxins and snake α-cobratoxin, on the survival and proliferation of C6 glioma cells. The effects of the lipoxygenase and cyclooxygenase inhibitors either alone or together with α-conotoxins and α-cobratoxin were studied in parallel. It was found that α-conotoxins and α-cobratoxin promoted the proliferation of C6 glioma cells, while nicotine had practically no effect at concentrations below 1 µL/mL. Nordihydroguaiaretic acid, a nonspecific lipoxygenase inhibitor, and baicalein, a 12-lipoxygenase inhibitor, exerted antiproliferative and cytotoxic effects on C6 cells. nAChR inhibitors weaken this effect after 24 h cultivation but produced no effects at longer times. Quantitative real-time polymerase chain reaction showed that mRNA for α4, α7, β2 and β4 subunits of nAChR were expressed in C6 glioma cells. This is the first indication for involvement of nAChRs in mechanisms of glioma cell proliferation

Development of Fruit Diseases of Microbial Origin During Storage at Treatment with Antioxidant Compositions

Present study addresses scientific substantiation of appropriateness of conducting after-harvesting treatment with antioxidant compositions for preventing the development of pathogenic microflora on the surface of fruits during long-term storage. We examined the fruits of apple of the varieties Idared, Golden Delicious, Simirenko Renet, the fruits of pear of the varieties Victoria, Izyuminka Crimea and Cure, the fruits of plum of the varieties Voloshka, Stanley, and Ugorka Italian. The fruits were treated by immersion in the following antioxidant compositions: ACM is a mixture of dimethylsulfoxide, ionol and polyethylene glycols; AARL is a mixture of ascorbic acid, rutine and lecithin; DL is a mixture of dimethylsulfoxide, ionol and lecithin. Control fruits were treated with water. Exposure is 10 seconds. Storage was maintained at a temperature of 0±1 ºC, at relative air humidity 90–95 %. It was established that during preparation of fruits for storing, the largest mean population of epiphytic microflora was registered on the surface of plums and pears with medium term of ripening. The species composition of epiphytic microflora was dominated by spores of mesophilic aerobic and facultative anaerobic microorganisms. Their mean population on the surface of apples was 9.6•103 cfu/g, on the surface of plums – 18•103 cfu/g. Treating all kinds of fruit with AOC significantly decreased speed of growth of both MAFAnM and micromycetes. It is shown that the application of composition reduced the level of daily losses from microbiological diseases over the entire period of storage by 2...3.5 times. The largest positive effect was obtained when applying the composition based on dystynol and lecithin. By performing a multi-factor analysis, it was revealed that the level of daily losses from microbiological diseases during storage was affected by the dominant influence of factors of generic features of fruit raw materials (factor A) and treatment with antioxidant compositions (factor D). The shares of influence are, respectively, 24 and 21