Chronic pelvic pain due to pelvic lymphangioleiomyomatosis: A case report

AbstractLymphangioleiomyomatosis (LAM), a rare multisystem disease affecting mainly young women, is characterized by an abnormal proliferation of smooth muscle-like cells in the lungs. We report a case of endometriosis with chronic pelvic pain due to pelvic LAM. A 41-year-old gravida 1, para 1 woman had been experiencing intermittent left pelvic pain for several years. She also complained of dyspnea on effort 2 years previously, and was diagnosed with pulmonary LAM. Abdominal magnetic resonance imaging showed a right ovarian endometriotic cyst and a left pelvic mass. She was referred to our hospital for the treatment of pelvic pain; she underwent laparoscopic cystectomy of the right ovarian endometriotic cyst. Her left pelvic cyst was found in the retroperitoneal space, and biopsy confirmed the diagnosis of LAM. Therefore, we suggest that LAM localized in the pelvis should be considered when a patient with pulmonary LAM presents with pelvic pain or abdominal distention

Simple and highly efficient method for transient in vivo gene transfer to mid-late pregnant mouse uterus

Shinsuke Koyama, Tadashi Kimura, Kazuhide Ogita, Hitomi Nakamura, Chisa Tabata, Khan Md Abu Hadi Noor Ali, Kumiko Temma-Asano, Koichiro Shimoya, Tateki Tsutsui, Masayasu Koyama, Yasufumi Kaneda, Yuji Murat

Mouse model of human infertility: transient and local inhibition of endometrial STAT-3 activation results in implantation failure

AbstractEmbryo implantation involves a series of biochemical reactions and its failure is an important therapeutic target of infertility treatment. We established an infertile mouse model using transient and local suppression of signal transducer and activator of transcription-3 (STAT-3) activity by STAT-3 decoy transfer into the uterine cavity during implantation, resulting in <30% implantation. This infertility is caused by suppression of decidualization, which is indispensable for implantation, and independent of progesterone. These conditions may mimic clinically unexplained infertility. Our results suggest that STAT-3 could be a useful target for diagnosis and therapy of human implantation failure