Assessment of cure by benznidazole (Bz) and posaconazole (Ps), administered in monotherapy or concomitant combinations, in a murine model of <i>Trypanosoma cruzi</i> infection¹.

1<p>Swiss female (n = 10) weight 20 to 24 g were inoculated with 5×10³ trypomastigotes (VL-10 strain).</p><p>Treatment was initiated at 7^th day after inoculation followed by 20 days and the drugs were administered orally. Benznidazole was given once daily and posaconazole administered twice a day (b.i.d.).</p>2<p>FBE – fresh blood examination performed before and after cyclophosphamide immunosuppression.</p>3<p>PCR assay was performed in the 1^st and 6^th month after treatment.</p

Efficacy of benznidazole (Bz) and posaconazole (Ps) treatments for 7 days (monotherapy or combination) in murine model of acute <i>Trypanosoma cruzi</i> infection¹.

1<p>Swiss female (n = 6) weight 20 to 24 g were inoculated with 5×10³ trypomastigotes (Ystrain).</p><p>Treatment was started at 4^th day after inoculation followed by 7 daily doses and the drugs were administered orally.</p>*<p>Significant difference in relation to benznidazole monotherapy treatment at same dose.</p><p>ND – Not detected.</p

Assessment of cure by benznidazole (Bz) and posaconazole (Ps), administered in monotherapy or sequential combinations, in a murine model of <i>Trypanosoma cruzi</i> infection¹.

1<p>Swiss female (n = 10) weight 20 to 24 g were inoculated with 5×10³ trypomastigotes (Y strain).</p><p>Treatment was initiated at 4^th day after inoculation followed by 10 or 20 daily doses and it was being orally administered.</p>2<p>FBE – fresh blood examination performed before and after cyclophosphamide immunossupression.</p>3<p>PCR assay was performed in the 1^st and 6^th month after treatment.</p>4<p>mpk – milligrams/kilogram/day.</p>5<p>All mice died before 30 days of infection.</p>6<p>All mice had positive results in fresh blood examination.</p

Benznidazole plus posaconazole therapy against VL-10 benznidazole resistant <i>Trypanosoma cruzi</i> stock.

<p>Maximum number of trypomastigote forms detected in the peripheral blood of mice infected with <i>Trypanosoma cruzi</i> VL-10 strain and treated with 100 mg/kg of bodyweight (mpk) of benznidazole (Bz) or 40 mpk of posaconazole (Ps) and with Bz plus Ps combination at the following dosages: 50 or 100 mpk of Bz in combination with 10 or 20 mpk of Ps for 20 consecutive days. Benznidazole was given daily and posaconazole twice a day (b.i.d.). IC – infected and untreated animals. a, b, c - different letters indicate significant differences, and the same letters indicates similar values among parasitemia levels.</p