Monolithic Integration of a Novel Microfluidic Device with Silicon Light Emitting Diode-Antifuse and Photodetector

Light emitting diode antifuse has been integrated into a microfluidic device that is realized with extended standard CMOS technological steps. The device comprises of a microchannel sandwiched between a photodiode detector and a nanometer-scale diode antifuse light emitter. Within this contribution, the device fabrication process, working principle and properties will be discussed. Change in the interference fringe of the antifuse spectra has been measured due to the filling of the channel. Preliminary applications are electroosmotic flow speed measurement, detection of absorptivity of liquids in the channe

Time resolution of the Atlas Tile calorimeter and its performance for a measurement of heavy stable particles

Time resolution of the Atlas Tile calorimeter modules has been measured using the test beam data. The resolution depends on an energy deposited in a given cell and is equal to about 1.5 $ns$ at $E$ = 1 $GeV$, 270 $ps$ at $E$ = 25 $GeV$ (high gain), 700 $ps$ at $E$ = 25 $GeV$ (low gain) and 170 $ps$ at $E$ = 150 $GeV$. These values have to be compared to the time of flight of relativistic particles to reach first samples of Tile calorimeter (from 8.3 $ns$ to 20 $ns$). Time of Flight measurement using Tile Calorimeter can be used to identify, and combined with momentum measurements by Atlas inner detector, to measure the mass of exotic heavy stable particles. The results are compared to previous analysis using the Atlas muon spectrometercite{KRAAN2}

Electronic band structure and carrier effective mass in calcium aluminates

First-principles electronic band structure investigations of five compounds of the CaO-Al2O3 family, 3CaO.Al2O3, 12CaO.7Al2O3, CaO.Al2O3, CaO.2Al2O3 and CaO.6Al2O3, as well as CaO and alpha-, theta- and kappa-Al2O3 are performed. We find that the conduction band in the complex oxides is formed from the oxygen antibonding p-states and, although the band gap in Al2O3 is almost twice larger than in CaO, the s-states of both cations. Such a hybrid nature of the conduction band leads to isotropic electron effective masses which are nearly the same for all compounds investigated. This insensitivity of the effective mass to variations in the composition and structure suggests that upon a proper degenerate doping, both amorphous and crystalline phases of the materials will possess mobile extra electrons

Nonequilibrium Electron Interactions in Metal Films

Ultrafast relaxation dynamics of an athermal electron distribution is investigated in silver films using a femtosecond pump-probe technique with 18 fs pulses in off-resonant conditions. The results yield evidence for an increase with time of the electron-gas energy loss rate to the lattice and of the free electron damping during the early stages of the electron-gas thermalization. These effects are attributed to transient alterations of the electron average scattering processes due to the athermal nature of the electron gas, in agreement with numerical simulations

Measurement-based modeling of bromine chemistry at the Dead Sea boundary layer ? Part 2: The influence of NO₂ on bromine chemistry at mid-latitude areas

International audienceUnderstanding the interaction between anthropogenic air pollution and Reactive Halogen Species (RHS) activity has had only limited support of direct field measurements, due to the fact that past field measurements of RHS have been mainly performed in Polar Regions. The present paper investigates the interaction between NO2 and Reactive Bromine Species (RBS) activity by model simulations based on extensive field measurements performed in the Dead Sea area, as described in a companion paper (Tas et al., 2006). The Dead Sea is an excellent natural laboratory for this investigation since elevated concentrations of BrO (up to more than 150 pptv) are frequently observed, while the average levels of NO2 are around several ppb. The results of the present study show that under the chemical mechanisms that occur at the Dead Sea, higher levels of NO2 lead to higher daily average concentrations of BrOX, as a result of an increase in the rate of the heterogeneous decomposition of BrONO2 that in turn causes an increase in the rate of the "Bromine Explosion" mechanism. The present study has shown that the influence of NO2 on BrOX production clearly reflects an enhancement of RBS activity caused by anthropogenic activity. However, above a certain threshold level of NO2 (daily average mixing ratios of 0.2 ppbv during RBS activity), the daily average concentrations of BrOX decrease for a further increase in the NO2 concentrations

Olive phenology as a sensitive indicator of future climatic warming in the Mediterranean

Experimental and modelling work suggests a strong dependence of olive flowering date on spring temperatures. Since airborne pollen concentrations reflect the flowering phenology of olive populations within a radius of 50 km, they may be a sensitive regional indicator of climatic warming. We assessed this potential sensitivity with phenology models fitted to flowering dates inferred from maximum airborne pollen data. Of four models tested, a thermal time model gave the best fit for Montpellier, France, and was the most effective at the regional scale, providing reasonable predictions for 10 sites in the western Mediterranean. This model was forced with replicated future temperature simulations for the western Mediterranean from a coupled ocean-atmosphere general circulation model (GCM). The GCM temperatures rose by 4·5 °C between 1990 and 2099 with a 1% per year increase in greenhouse gases, and modelled flowering date advanced at a rate of 6·2 d per °C. The results indicated that this long-term regional trend in phenology might be statistically significant as early as 2030, but with marked spatial variation in magnitude, with the calculated flowering date between the 1990s and 2030s advancing by 3–23 d. Future monitoring of airborne olive pollen may therefore provide an early biological indicator of climatic warming in the Mediterranean

Discovery of Innovative Therapies for Rare Immune-Mediated Inflammatory Diseases via Off-Label Prescription of Biologics: The Case of IL-6 Receptor Blockade in Castleman’s Disease

Biologics have revolutionized the field of clinical immunology and proven to be both effective and safe in common immune-mediated inflammatory diseases (IMIDs) such as rheumatoid arthritis, inflammatory bowel diseases, and various hematological disorders. However, in patients with rare, severe IMIDs failing on standard therapies, it is virtually impossible to conduct randomized controlled trials. Therefore, biologics are usually prescribed off-label in these often severely ill patients. Unfortunately, off-label prescription is sometimes hampered in these diseases due to a lack of reimbursement that is often based on a presumed lack of evidence for effectiveness. In the present article, we will discuss that off-label prescription of biologics can be a good way to discover new treatments for rare diseases. This will be illustrated using a case of multicentric Castleman's disease, an immune-mediated lymphoproliferative disorder, in which off-label tocilizumab (humanized anti-IL-6 receptor blocking antibody) treatment resulted in remarkable clinical improvement. Furthermore, we will give recommendations for monitoring efficacy and safety of biologic treatment in rare IMIDs, including the use of registries. In conclusion, we put forward that innovative treatments for rare IMIDs can be discovered via off-label prescription of biologicals, provided that this is based on rational arguments including knowledge of the pathophysiology of the diseas

Femtosecond nonlinear ultrasonics in gold probed with ultrashort surface plasmons

Fundamental interactions induced by lattice vibrations on ultrafast time scales become increasingly important for modern nanoscience and technology. Experimental access to the physical properties of acoustic phonons in the THz frequency range and over the entire Brillouin zone is crucial for understanding electric and thermal transport in solids and their compounds. Here, we report on the generation and nonlinear propagation of giant (1 percent) acoustic strain pulses in hybrid gold/cobalt bilayer structures probed with ultrafast surface plasmon interferometry. This new technique allows for unambiguous characterization of arbitrary ultrafast acoustic transients. The giant acoustic pulses experience substantial nonlinear reshaping already after a propagation distance of 100 nm in a crystalline gold layer. Excellent agreement with the Korteveg-de Vries model points to future quantitative nonlinear femtosecond THz-ultrasonics at the nano-scale in metals at room temperature

Optical sideband generation up to room temperature with mid-infrared quantum cascade lasers

Room temperature sideband generation on an optical carrier is demonstrated using midinfrared quantum cascade lasers. This is achieved via an enhancement of the nonlinear susceptibility via resonant interband and intersubband excitations, compensating the large phase-mismatch

DE Canum Venaticorum : a bright, eclipsing red dwarf–white dwarf binary

Context. Close white dwarf–red dwarf binaries must have gone through a common-envelope phase during their evolution. DE CVn is a detached white dwarf–red dwarf binary with a relatively short (∼8.7 h) orbital period. Its brightness and the presence of eclipses makes this system ideal for a more detailed study. Aims. From a study of photometric and spectroscopic observations of DE CVn we derive the system parameters that we discuss in the framework of common-envelope evolution. Methods. Photometric observations of the eclipses are used to determine an accurate ephemeris. From a model fit to an average lowresolution spectrum of DE CVn, we constrain the temperature of the white dwarf and the spectral type of the red dwarf. The eclipse light curve is analysed and combined with the radial velocity curve of the red dwarf determined from time-resolved spectroscopy to derive constraints on the inclination and the masses of the components in the system. Results. The derived ephemeris is HJDmin = 2 452 784.5533(1) + 0.3641394(2) × E. The red dwarf in DE CVn has a spectral type of M3V and the white dwarf has an effective temperature of 8 000 K. The inclination of the system is 86+3◦ −2 and the mass and radius of the red dwarf are 0.41 ± 0.06 M and 0.37+0.06 −0.007 R, respectively, and the mass and radius of the white dwarf are 0.51+0.06 −0.02 M and 0.0136+0.0008 −0.0002 R, respectively. Conclusions. We found that the white dwarf has a hydrogen-rich atmosphere (DA-type). Given that DE CVn has experienced a common-envelope phase, we can reconstruct its evolution and we find that the progenitor of the white dwarf was a relatively lowmass star (M ≤ 1.6 M). The current age of this system is 3.3−7.3 × 109 years, while it will take longer than the Hubble time for DE CVn to evolve into a semi-detached system