1 research outputs found
Synthesis and Activity of 6″-Deoxy-6″-thio-α-GalCer and Peptide Conjugates
A major challenge in the development
of highly defined synthetic
vaccines is the codelivery of vaccine components (i.e., antigen and
adjuvant) to secondary lymphoid tissue to induce optimal immune responses.
This problem can be addressed by synthesizing vaccines that comprise
peptide antigens covalently attached to glycolipid adjuvants through
biologically cleavable linkers. Toward this, a strategy utilizing
previously unreported 6″-deoxy-6″-thio analogues of
α-GalCer that can undergo chemoselective conjugation with peptide
antigens is described. Administration of these conjugate vaccines
leads to enhanced priming of antigen specific T cells. This simple
vaccine design is broadly applicable to multiple disease indications
such as cancer and infectious disease