13 research outputs found
Mechanistic Surprises in the Gold(I)-Catalyzed Intramolecular Hydroarylation of Allenes
Zwei machen die Show: Mechanistische Studien ĂĽber die Cyclisierung von allenischen Arenen zeigen, dass die Ruheform des Katalysators ein zweikerniges verbrĂĽcktes Vinylsystem ist. Dieses wurde..
Tin can
Tin has been ubiquitous throughout the course of human history, from Bronze Age tools to lithium-ion battery components, yet Michael A. Tarselli warns it should not be deemed pedestrian. Its tendency to linger in human tissues presents a dangerous side that steers researchers towards greener chemistries
Unzipping Natural Products: Improved Natural Product Structure Predictions by Ensemble Modeling and Fingerprint Matching
This pre-print explores ensemble modeling of natural product targets to match chemical structures to precursors found in large open-source gene cluster repository antiSMASH. Commentary on method, effectiveness, and limitations are enclosed. All structures are public domain molecules and have been reviewed for release
Big Data from Pharmaceutical Patents: A Computational Analysis of Medicinal Chemists’ Bread and Butter
Multiple recent studies
have focused on unraveling the content
of the medicinal chemist’s toolbox. Here, we present an investigation
of chemical reactions and molecules retrieved from U.S. patents over
the past 40 years (1976–2015). We used a sophisticated text-mining
pipeline to extract 1.15 million unique whole reaction schemes, including
reaction roles and yields, from pharmaceutical patents. The reactions
were assigned to well-known reaction types such as Wittig olefination
or Buchwald–Hartwig amination using an expert system. Analyzing
the evolution of reaction types over time, we observe the previously
reported bias toward reaction classes like amide bond formations or
Suzuki couplings. Our study also shows a steady increase in the number
of different reaction types used in pharmaceutical patents but a trend
toward lower median yield for some of the reaction classes. Finally,
we found that today’s typical product molecule is larger, more
hydrophobic, and more rigid than 40 years ago