Anemia and Related Factors in Preschool Children in the Southern Rural Lao People’s Democratic Republic

Anemia is a severe public health problem in the Lao People’s Democratic Republic (PDR). Consequently, a new control strategy to reduce the burden of anemia has been introduced for preschool children (aged 6–52 months). The objective of this study was to assess the current prevalence of anemia and related factors in preschool children in southern rural Lao PDR. A population-based cross-sectional study was carried out in six communities in Songkhone district, Savannakheth province, in February 2009. As a result, the prevalence of anemia was found to be 48.9% (95% confidence interval (CI), 43.5–54.3), although most cases were mild. A multiple logistic regression analysis indicated that there was no protective effect of breastfeeding against anemia. The anemia prevalence was higher in 1) children aged 6–23 months (Odds Ratio (OR) = 1.73, 95% CI, 1.02–2.90) than in older children, 2) children in large families (6 or more members) (OR = 1.96, 95% CI, 1.17–3.29), and 3) children in three remote villages with relatively difficult access to markets (OR = 3.01, 95% CI, 1.25–7.47)

Effect of daily versus weekly home fortification with multiple micronutrient powder on haemoglobin concentration of young children in a rural area, Lao People's Democratic Republic: a randomised trial

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.Abstract Background Multiple micronutrient deficiencies, in particular iron deficiency anaemia (IDA) is a severe public health problem in Lao People's Democratic Republic (Lao PDR). Because of the practical difficulties encountered in improving the nutritional adequacy of traditional complementary foods and the limitations associated with the use of liquid iron supplementation for the treatment and prevention of IDA in infants and young children, recently, home-fortification with multivitamins and minerals sprinkles was recommended. This study aims to compare the effect of twice weekly versus daily supplementation with multivitamins and minerals powder (MMP) on anaemia prevalence, haemoglobin concentration, and growth in infants and young children in a rural community in Lao PDR. Methods A randomized trial was conducted in six rural communities. Children aged 6 to 52 months (n = 336) were randomly assigned to a control group (n = 110) or to one of two intervention groups receiving either two sachets per week (n = 115) or a daily sachet (n = 111) of MMP for 24 weeks; 331 children completed the study. A finger prick of blood was taken at baseline, at week 12, and again at week 24 to determine haemoglobin concentration. Anthropometric measurements were taken every 4 weeks. The McNemar test was used to assess within group differences at three time points in the study subjects with anaemia and one-way ANOVA was used to assess changes in mean haemoglobin concentration in the treatment groups. Results MMP supplementation resulted in significant improvements in haemoglobin concentration and in the reduction of anaemia prevalence in the two treatment groups compared with the control group (p <0.001). The severely to moderately anaemic children (Hb <100 g/L) on daily supplementation recovered faster than those on twice weekly supplementation. MMP was well accepted and compliance was high in both treatment groups. Overall, the improvement in the weight for age Z-score was very small and not statistically significant across the three study groups. Conclusions MMP supplementation had positive effects in reduction of anaemia prevalence and in improving haemoglobin concentration. For severely to moderately anaemic children, daily MMP supplementation was more effective in improving haemoglobin concentration and reducing anaemia prevalence. A longer intervention period is probably needed to have a positive effect on growth.Peer Reviewe

Regional Differences in the Growing Incidence of Dengue Fever in Vietnam Explained by Weather Variability

Dengue fever is a major health problem in Vietnam, but its incidence differs from province to province. To understand this at the local level, we assessed the effect of four weather components(humidity, rainfall, temperature and sunshine) on the number of dengue cases in nine provinces of Vietnam. Monthly data from 1999 to 2009 were analysed by time-series regression using negative binomial models. A test for heterogeneity was applied to assess the weather-dengue association in the provinces. Those associations were significantly heteroge neous(for temperature, humidity, and sunshine: P<0.001 heterogeneity test; for rainfall: P=0.018 heterogeneity test). This confirms that weather components strongly affect dengue transmission at a lag time of 0 to 3 months, with considerable variation in their influence among different areas in Vietnam. This finding may promote the strategic prevention of dengue disease by suggesting specific plans at the local level, rather than a nationally unified approach

Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese

The neuronal nitric oxide synthase gene (NOS1) is located at 12q24, a susceptibility region for schizophrenia, and produces nitric oxide (NO). NO has been reported to play important roles as a gaseous neurotransmitter in brain. NO is a second messenger for the N-methyl-D aspartate (NMDA) receptor and is related to the dopaminergic system. Because the symptomatology of methamphetamine (METH) use disorder patients with psychosis is similar to that of patients with schizophrenia, NOS1 is a good candidate gene for METH-induced psychosis. Therefore, we conducted a case-control association study between NOS1 and METH-induced psychosis with Japanese subjects (183 with METH-induced psychosis patients and 519 controls). We selected seven SNPs (rs41279104, rs3782221, rs3782219, rs561712, rs3782206, rs6490121, rs2682826) in NOS1 from previous reports. Written informed consent was obtained from each subject. This study was approved by the Ethics Committee at Fujita Health University School of Medicine and each participating institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). No significant association was found between NOS1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS1 might not contribute to the risk of METH-induced psychosis in the Japanese population

Corrigendum to “Efficiency and stability under substitutable priorities with ties” [J. Econ. Theory 184 (2019) 104950]

We identify an error in Proposition 3 by Erdil and Kumano (2019). We then recover the result by replacing the substitutability condition on priority structures with a new condition which we call bridging. We further show that the priorities in both applications in Erdil and Kumano (2019) satisfy the bridging property, which in turn ensures that their Propositions 5 and 6 are still valid

Hierarchical Back-off Modeling of Hiero Grammar based on Non-parametric Bayesian Model

In hierarchical phrase-based machine translation, a rule table is automatically learned by heuristically extracting syn-chronous rules from a parallel corpus. As a result, spuriously many rules are extracted which may be composed of various incorrect rules. The larger rule table incurs more run time for decoding and may result in lower translation quality. To resolve the problems, we propose a hierarchical back-off model for Hiero grammar, an instance of a synchronous context free grammar (SCFG), on the basis of the hierarchical Pitman-Yor process. The model can extract a compact rule and phrase table without resorting to any heuristics by hierarchically backing off to smaller phrases under SCFG. Inference is efficiently carried out using two-step synchronous parsing of Xiao et al., (2012) combined with slice sampling. In our experiments, the proposed model achieved higher or at least comparable translation quality against a previous Bayesian model on various language pairs; German/French/Spanish/Japanese-English. When compared against heuristic models, our model achieved comparable translation quality on a full size German-English language pair in Europarl v7 corpus with significantly smaller grammar size; less than 10 % of that for heuristic model.

The Multifaceted Role of Plasminogen in Cancer

Fibrinolytic factors like plasminogen, tissue-type plasminogen activator (tPA), and urokinase plasminogen activator (uPA) dissolve clots. Though mere extracellular-matrix-degrading enzymes, fibrinolytic factors interfere with many processes during primary cancer growth and metastasis. Their many receptors give them access to cellular functions that tumor cells have widely exploited to promote tumor cell survival, growth, and metastatic abilities. They give cancer cells tools to ensure their own survival by interfering with the signaling pathways involved in senescence, anoikis, and autophagy. They can also directly promote primary tumor growth and metastasis, and endow tumor cells with mechanisms to evade myelosuppression, thus acquiring drug resistance. In this review, recent studies on the role fibrinolytic factors play in metastasis and controlling cell-death-associated processes are presented, along with studies that describe how cancer cells have exploited plasminogen receptors to escape myelosuppression

Hierarchical Back-off Modeling of Hiero Grammar based on Non-parametric Bayesian Model

In hierarchical phrase-based machine translation, a rule table is automatically learned by heuristically extracting syn-chronous rules from a parallel corpus. As a result, spuriously many rules are extracted which may be composed of various incorrect rules. The larger rule table incurs more run time for decoding and may result in lower translation quality. To resolve the problems, we propose a hierarchical back-off model for Hiero grammar, an instance of a synchronous context free grammar (SCFG), on the basis of the hierarchical Pitman-Yor process. The model can extract a compact rule and phrase table without resorting to any heuristics by hierarchically backing off to smaller phrases under SCFG. Inference is efficiently carried out using two-step synchronous parsing of Xiao et al., (2012) combined with slice sampling. In our experiments, the proposed model achieved higher or at least comparable translation quality against a previous Bayesian model on various language pairs; German/French/Spanish/Japanese-English. When compared against heuristic models, our model achieved comparable translation quality on a full size German-English language pair in Europarl v7 corpus with significantly smaller grammar size; less than 10 % of that for heuristic model.