6 research outputs found
Vitamin E Protects Against Oxidative Damage Caused By Cadmium In The Blood Of Rats
Aim: The protective effect of vitamin E (vit E) on cadmium (Cd) induced
oxidative stress was studied in the blood of rats. Methods: The rats
were randomly divided in to three experimental groups: Control, Cd
treated and Cd + vit E treated, each contain-ing 10 animals. The Cd
treated and Cd + vit E treated groups were injected subcutaneously
daily with CdCl2 dissolved in isotonic NaCl in the amount of 2 mL/kg
for 20 days, resulting in a dosage of 0.49 mg Cd/kg/d. In addition, Cd
+ vit E treated group received intramuscular injection of 150 mg/kg vit
E until the end of the study. Results: Cd treatment increased
significantly malondialdehyde (MDA) levels and the antioxidant enzyme
activities of superoxide dismutase (SOD), glutathione peroxidase
(GSH-Px) and catalase (CAT) in plasma and erythrocytes compared to the
control group. Cd + vit E treatment, decreased significantly elevated
MDA lev-els in plasma and erythrocyte and also reduced significantly
the enhanced antioxidant levels. Cd treatment increased significantly
the activity of iron levels in the plasma compared to the control
group. Cd + vit E treatment, decreased the activity of iron levels in
the plasma compared to the Cd treated group. In the control group, the
histology of erythrocytes was normal. In Cd treated group, there was
marked membrane destruction and there were hemolytic changes in
erythrocytes. In Cd + vit E treated group, these changes were less than
Cd treated group. Conclussion: Our results show that vit E exerts a
protective effect against cadmium toxicity