Hazard Ratios from Cox Regression Models for Baseline Troponin Assessed by Contemporary-Sensitivity, High-Sensitivity and Super-Sensitivity Assays for Various Endpoints after Adjustment for the Framingham Risk Score.

<p>Shown are the hazard ratios for continuous troponin concentration per 1-SD increment and for categorical troponin concentration, comparing the highest with the lowest defined category. Please see the footnote to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0090063#pone-0090063-t002" target="_blank">Table 2</a> for cut points of the categories.</p><p>Abbreviations: MACE = major adverse cardiac events, CVD = cardiovascular disease, MI = myocardial infarction, HF = heart failure, HR = hazard ratio, CI = confidence interval, cs-cTnI = troponin I measured by contemporary-sensitivity assay, hs-cTnI = highly sensitive troponin, ss-cTnI = supersensitive troponin, ns = not significant.</p

Baseline Characteristics of the Study Population by Gender.

<p>Persons with prevalent MACE and pregnant women have been excluded. Binary variables are shown in absolute counts and percentages. For continuous variables the median and the IQR are shown.</p><p>MI = Myocardial infarction, MACE = major adverse cardiac events, BP = blood pressure, HDL = high-density-lipoprotein, CRP = c-reactive protein, NT-proBNP = N-terminal pro-brain natriuretic peptide, IQR = interquartile range, CVD = cardiovascular disease, cs-cTnI = troponin I measured by contemporary-sensitivity assay, hs-cTnI = troponin I measured by high-sensitivity assay, ss-cTnI = troponin measured by super-sensitivity assay</p

Kaplan-Meier Curves According to Troponin Categories as Measured by Contemporary-Sensitivity, High-Sensitivity and Super-Sensitivity Assays for MACE and HF after Adjustment for Age and Gender.

<p>Dotted lines indicate the 95% confidence intervals. MACE = major adverse cardiac events, cs-cTnI = troponin I measured by contemporary-sensitivity assay, hs-cTnI = highly sensitive troponin I measured by high-sensitivity assay, ss-cTnI = troponin I measured by super-sensitivity assay. Please see the footnote to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0090063#pone-0090063-t002" target="_blank">Table 2</a> for the cut points of the troponin categories.</p

Net Reclassification Improvement (NRI) and Clinical NRI for Various Endpoints for Baseline Troponin Assessed by Contemporary-Sensitivity, High-Sensitivity and Super-Sensitivity Assays in Addition to the Standard Framingham Risk Score.

<p>NRI = net reclassification improvement, clinical NRI = NRI for individuals with an intermediate 10-year risk (5–20%) according to the Framingham Risk Score, MACE = major adverse cardiac events, CVD = cardiovascular disease, MI = myocardial infarction, HF = heart failure, cs-cTnI = troponin I measured by contemporary-sensitivity assay, hs-cTnI = troponin I measured by high-sensitivity assay, ss-cTnI = troponin I measured by super-sensitivity assay, ns = not significant.</p

Absolute and Relative Distributions of Troponin I Concentrations in the Study Population.

<p>The categories were defined as follows. For the contemporary-sensitivity assay, troponin category 1 is 0–1 pg/mL (lowest observed non-zero value), category 2 is 1–10 pg/mL (LOD), and category 3 is >10 pg/mL. For the high-sensitivity assay, troponin category 1 is 0–1.9 pg/mL (LOD), category 2 1.9–5.1 pg/mL (same percentile as 10 pg/mL for contemporary troponin), and category 3 is >5.1 pg/mL. For the super-sensitivity assay, troponin category 1 is 0–1.0 pg/mL (median limit of detection), category 2 1.0–5.1 pg/mL (according to the percentiles of contemporary troponin), and category 3 is >5.1 mg/mL.</p><p>cs-cTnI = troponin I measured by contemporary-sensitivity assay, hs-cTnI = troponin I measured by high-sensitivity assay, ss-cTnI = troponin I measured by super-sensitivity assay, LOD = limit of detection.</p