The association between iron deficiency anemia and febrile seizure

Objective Different studies have reported contradictory results regarding the relationship between iron deficiency anemia (IDA) and febrile seizure (FS). The present study was conducted to determine the effect of IDA on FS in children. Patients and methods This case-control study was conducted among 52 children with FS (the case group) and 18 children with afebrile seizures and 51 children with fever without seizures in the age range of 6 months to 5 years admitted to the pediatric ward of Imam Khomeini Hospital in Ilam from March 2016 to January 2017. Patients were selected using the convenience sampling method. Red blood cell (RBC) count as well as measurement of hemoglobin (Hb), hematocrit (Hct), ferritin, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) levels were performed in all patients. The collected data were analyzed using SPSS16 software. Results A total of 34.6 in the FS group, 66.7 in the afebrile seizure group and 41.2 in the fever without seizure group suffered from IDA, which was not statistically significant between the three groups. Hb, Hct and RBC levels were higher in the case group and MCV, MCH, MCHC levels in the case group were lower than those in the control group. The odds ratio (OR) for FS compared to the febrile group was 0.756 95% confidence interval (CI) = 0.34-1.68; p = 0.493 and that for FS compared to seizure was 0.265 (95% CI = 0.085-0.823; p = 0.022). Conclusions This study showed that IDA may have protective effects on the onset of FS, and based on the results, IDA is more common in children with afebrile seizures. Further and more comprehensive studies are recommended

The Association Between Borna Disease Virus and Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis

Context: Several studies have controversial results regarding the association between Borna disease virus (BDV) and chronic fatigue syndrome (CFS). The present systematic review and meta-analysis investigated the association between CFS and BDV. Evidence Acquisition: The present study was conducted based on the PRISMA guidelines for systematic review and meta-analysis studies. To avoid bias, all procedures of the study were performed by two researchers independently. A comprehensive search was performed using online databases, including PubMed, Scopus, Embase, PsycINFO, science Direct, Cochrane Library, web of science, and Google scholar using the MeSH keywords until December 12th, 2016. Heterogeneity among studies was evaluated using Cochran's Q test I-2 Index. Finally, the random effect model was used for combined Odds Ratio (OR) using Review Manger software version 5.3.5. Results: Among 9 eligible studies comprising 610 cases and 2176 controls, the total OR for association between BDV and CFS was estimated to be 10.41 (95 confidence interval CI: 4.24 - 25.55, P < 0.0001). For subgroup analysis by the diagnostic methods (ELISA, RT-PCR, and Western blot), OR was 2.47 (95% CI: 0.77 - 7.96, P=0.13), 12.20 (95% CI: 1.66 - 89.57, P=0.01), and 28.36 (95% CI: 3.76- 213.85, P=0.001), respectively (test for subgroup differences: P=0.08; I-2=59.5). Subgroup analysis for BDV and CFS association by antigens and antibodies had an OR of 12.20 (1.66, 89.57) and 8.20 (3.32, 20.22), respectively (test for subgroup differences: P=0.72; I-2=0). Conclusions: This study supports the association between BDV and CFS and shows the role of viral agents in etiology of CFS. Therefore, viral agents may play a role in the etiology of neuropsychiatric disorders

Endovenous Laser Ablation for Varicose Vein Treatment: A Systematic Review and Meta-Analysis

Varicose veins are among the common problems affecting the quality of life. Endovenous laser ablation (EVLA) has been introduced as a noninvasive treatment for varicose veins. This study was performed according to the Meta-analyses Of Observational Studies in Epidemiology (MOOSE) protocol, and the results were reported based on Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. MeSH keywords were searched in several online databases. Heterogeneity among studies was assessed using Cochran's Q test and I-2 index, and the random-effects model. Data were analyzed using Comprehensive Meta-analysis software version 2. EVLA success, recurrence and recanalization rates were 94.5, 10.3 and 3.6, respectively. EVLA complications in the treatment of varicose veins were ecchymosis (41.3), pain (26.1), bruising (24.2), induration (22.7), edema (8.3), phlebitis (4.8), dyspigmentation (4.1), venous thrombosis (3.7), thrombophlebitis (3.7), paresthesia (3.1), thermal injury (1.8), hematoma (1.7), cellulitis (1.4), bleeding (0.9), infection (0.9), nerve injury (0.9), deep vein thrombosis (DVT) (0.6) and pulmonary thromboembolism (PTE) (0.4). The success rate of EVLA increased with an increase in wavelength and peaked at 1470 nm (nm). The highest rate of recurrence and recanalization was at 810 nm and 940 nm, and the lowest was at 1470 nm. EVLA is an effective, less invasive and mostly safe treatment with no need to general anesthesia and also minor complications. The follow-up duration and geographical location of studies also provide insight into the differences in success rate, recurrence and recanalization rate of EVLA

Endovenous Laser Ablation for Varicose Vein Treatment: A Systematic Review and Meta-Analysis

Varicose veins are among the common problems affecting the quality of life. Endovenous laser ablation (EVLA) has been introduced as a noninvasive treatment for varicose veins. This study was performed according to the Meta-analyses Of Observational Studies in Epidemiology (MOOSE) protocol, and the results were reported based on Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. MeSH keywords were searched in several online databases. Heterogeneity among studies was assessed using Cochran's Q test and I-2 index, and the random-effects model. Data were analyzed using Comprehensive Meta-analysis software version 2. EVLA success, recurrence and recanalization rates were 94.5, 10.3 and 3.6, respectively. EVLA complications in the treatment of varicose veins were ecchymosis (41.3), pain (26.1), bruising (24.2), induration (22.7), edema (8.3), phlebitis (4.8), dyspigmentation (4.1), venous thrombosis (3.7), thrombophlebitis (3.7), paresthesia (3.1), thermal injury (1.8), hematoma (1.7), cellulitis (1.4), bleeding (0.9), infection (0.9), nerve injury (0.9), deep vein thrombosis (DVT) (0.6) and pulmonary thromboembolism (PTE) (0.4). The success rate of EVLA increased with an increase in wavelength and peaked at 1470 nm (nm). The highest rate of recurrence and recanalization was at 810 nm and 940 nm, and the lowest was at 1470 nm. EVLA is an effective, less invasive and mostly safe treatment with no need to general anesthesia and also minor complications. The follow-up duration and geographical location of studies also provide insight into the differences in success rate, recurrence and recanalization rate of EVLA

A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Cohort Studies to Study the Efficacy of Ultrasound-Guided Foam Sclerotherapy for Varicose Vein Treatment

Varicose veins are common disorders that affect the quality of life of sufferers due to the symptoms they cause. The efficacy of different varicose vein treatments has been studied extensively, with varying success rates. Less invasive treatments, such as sclerotherapy, can be mentioned among the proposed therapies. This study investigates the efficacy of ultrasound-guided foam sclerotherapy (UGFS) for treating varicose veins. In this study, the results were reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines of the Meta-analysis of Observational Studies in Epidemiology (MOOSE) protocol. By searching in 11 databases as well as the Google Scholar search engine using the keywords "varicose vein," "foam sclerotherapy," "occlusion," "success," "Duplex-guided foam sclerotherapy," "efficacy," and "Ultrasound-Guided Foam Sclerotherapy," randomized clinical trial (RCT) and cohort articles published until July 2022 were collected. The required information was extracted and analyzed using Comprehensive Meta-analysis (CMA) software version 2. Data analysis of 35 randomized clinical trial articles showed that the success rate of ultrasound-guided foam sclerotherapy in the treatment of varicose veins is 78 (95 CI: 73-83; P value < 0.001) (I-2 = 89.11, P value < 0.001). The subgroup analysis showed that the success of this method is more in the form of sodium tetradecyl sulfate and polidocanol 2 foam and in a period of fewer than 3 months from the start of treatment and in the Asian race. Also, the analysis of 8 cohort studies showed that the success rate of ultrasound-guided foam sclerotherapy in the treatment of varicose veins is 81 (95 CI: 65-91; P value < 0.001). The most prevalent complications of this method in the treatment of varicose veins were induration, thrombophlebitis, bruising, dyspigmentation, hematoma, pain, and phlebitis. Present study illustrated that the effectiveness of ultrasound-guided foam sclerotherapy in the treatment of varicose veins is high. However, it was significantly less successful than published meta-analyses on other less invasive methods such as radiofrequency ablation (RFA) and endovenous laser ablation (EVLA). Also, this method showed more major complications than our previous study on the effect of endovenous laser ablation in the treatment of varicose veins. Factors such as foam type, follow-up duration, and racial differences can affect the study's results

Efficacy of Radiofrequency Ablation (RFA) in the Treatment of Varicose Veins: a Systematic Review and Meta-analysis

Varicose veins are a common disorder for which different treatments with varied efficacy have been introduced so far. In this study, we review the results of previous studies to evaluate the efficacy of ClosureFast endovenous radiofrequency ablation (RFA) in treating varicose veins. The present study was performed based on the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) protocols, and the results were reported based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guideline. Searches were conducted in all authentic online databases, and the retrieved papers were conducted until March 2021 using Mesh keywords. Study data with the necessary quality to enter the meta-analysis were extracted. Data were analyzed using comprehensive meta-analysis (CMA) software version 2. The cutoff level for significance was determined at 0.05. In total, 36 studies with sample size 7404 procedures were included. Radiofrequency ablation success, recurrence, and recanalization rates in the treatment of varicose veins were estimated to be 95, 7, and 3 respectively. The most common complications were bruising 13, induration 11.6, edema 8, ecchymosis 7.4, and numbness 6.3. This study showed that the radiofrequency ablation method is a high-performance method with few and often transient complications, and the risk of significant complications in using this method to treat varicose veins is low. More studies are needed to evaluate the effectiveness of this method compared to other treatments

The prevalence of metabolic syndrome in patients with polycystic ovary syndrome: A systematic review and meta-analysis

Introduction: Polycystic ovary syndrome (PCOS) is an endocrinopathy with unknown pathophysiology among women of reproductive age. Several studies have been conducted to determine the prevalence of metabolic syndrome (MetS) among PCOS patients. However, the results were contradictory. The present study was conducted to evaluate the prevalence of MetS in PCOS patients using the related published data. Method: The present systematic review was perfumed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The search was done using MeSH keywords in databases of PubMed, Scopus, Embase, CINAHL, Web of Science, Cochrane Library, EBSCO, and Google scholar search engine as well as the reference list of the retrieved papers without time limit until October 2018. We used Cochran's Q test and I-2 Index to evaluate the heterogeneity among the studies and the random effects model was used to combine the results. Data analysis was performed using Stata ver. 11.1. Results: Forty six studies including 8946 patients with PCOS were included in the final analysis. Total heterogeneity was high (I-2 : 91.43, P <0.001). The prevalence of MetS in PCOS patients was estimated to be 30 (95CI: 27-33). Subgroup analysis based on MetS diagnostic criteria showed an estimated prevalence of 0.27 (95CI: 0.18-0.37), 0.30 (95Cl: 0.27-0.34), 0.32 (95CI: 0.25-0.39), 0.32 (95CI: 0.27-0.37) and 0.24 (95CI: 0.14-0.34) for IDF, NECP-ATPIII, AHA NHLBI, CDS, and unknown criteria, respectively. Conclusion: Considering the prevalence of MetS in PCOS patients, diagnosis of MetS in PCOS patients is necessary to reduce the mortality and morbidity rates. (C) 2019 Published by Elsevier Ltd on behalf of Diabetes India

Efficacy of Radiofrequency Ablation (RFA) in the Treatment of Varicose Veins: a Systematic Review and Meta-analysis

Varicose veins are a common disorder for which different treatments with varied efficacy have been introduced so far. In this study, we review the results of previous studies to evaluate the efficacy of ClosureFast endovenous radiofrequency ablation (RFA) in treating varicose veins. The present study was performed based on the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) protocols, and the results were reported based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guideline. Searches were conducted in all authentic online databases, and the retrieved papers were conducted until March 2021 using Mesh keywords. Study data with the necessary quality to enter the meta-analysis were extracted. Data were analyzed using comprehensive meta-analysis (CMA) software version 2. The cutoff level for significance was determined at 0.05. In total, 36 studies with sample size 7404 procedures were included. Radiofrequency ablation success, recurrence, and recanalization rates in the treatment of varicose veins were estimated to be 95, 7, and 3 respectively. The most common complications were bruising 13, induration 11.6, edema 8, ecchymosis 7.4, and numbness 6.3. This study showed that the radiofrequency ablation method is a high-performance method with few and often transient complications, and the risk of significant complications in using this method to treat varicose veins is low. More studies are needed to evaluate the effectiveness of this method compared to other treatments

The association between Borna Disease Virus and schizophrenia: A systematic review and meta-analysis

Introduction: Schizophrenia is a disabling psychiatric disorder. The role of Borna Disease Virus (BDV) in the etiology of schizophrenia has been suggested by several studies. However, the existence of such association remained controversial. The present meta-analysis was conducted to evaluate this association. Method: This systematic review and meta-analysis was conducted using preferred reporting items for systematic reviews and meta-analysis (PRISMA). Online databases including Scopus, PubMed, Science direct, Embase, PsycINFO, Web of Science and Google scholar search engine were searched until January 15, 2017. The heterogeneity of the studies was evaluated using Cochran's Q test and I-2 statistic. Finally, random effects model was used for combining the results using Stata software version 11.1. Result: Overall, 30 studies containing 2533 cases and 4004 controls were included in the meta-analysis. The combined odds ratio (OR) for the relationship between BDV and schizophrenia was estimated to be 2.72 (95 CI: 1.75-4.20). This association based on RT-PCR, WB, IFA, EIA, RLA, ECLIA methods was estimated to be 3.83 (95 CI: 1.59-9.20), 4.99 (95 CI: 1.80-13.85), 1.27 (95 CI: 0.23-7.12), 2.26 (95 CI: 0.48-10.64), 1.67 (95 CI: 0.50-5.56) and 2.88 (95 CI: 1.38-6.01), respectively. Subgroup analysis according to WBC, serum and plasma samples was estimated to be 3.31 (95 CI: 1.19-9.25), 2.21 (95 CI: 1.17-4.17), 2.21 (95 CI: 1.03-4.73) and 7.89 (95 CI: 1.75-35.53), respectively. Conclusion: The results indicated the role of BDV in the etiology of schizophrenia

The association between psoriasis and diabetes mellitus: A systematic review and meta-analysis

Background: Psoriasis is an immune-mediated chronic inflammatory skin disease with unknown etiology. Current findings demonstrate that psoriatic patients are at higher risk of other systemic disorders such as diabetes mellitus. The present study was conducted to evaluate the association between psoriasis and diabetes mellitus. Method: The current study was conducted based on preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. Using MeSH keywords we searched online databases of PubMed, Scopus, Web of Science, Science Direct, Embase, CINAHL, Cochrane Library, EBSCO and Google scholar search engine and the reference list of the retrieved articles until June 2018. Heterogeneity among studies was assessed using Cochran's Q test and I 2 index and the random effects model was used to estimate Odds Ratio (OR) and 95 confidence interval (CI). Data were analyzed using Comprehensive Meta-Analysis (CMA) software version 2. Results: Analysis of 38 eligible studies involving 922870 cases and 12808071 controls suggested the estimated OR to be 1.69 (95 Confidence Interval CI: 1.51–1.89; P &lt; 0.001). Subgroup analysis was conducted based on study design and country of study and was significant (test for subgroup differences: P = 0.025 and P &lt; 0.001, respectively). Conclusions: Our study indicated the significant association between psoriasis and diabetes. Therefore, psoriasis is a systemic disorder and other comorbidities should be considered in the management of patients with psoriasis. © 201