21 research outputs found
The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity
Get PDFDeregulated metabolism is a well-established hallmark of cancer. At the hub of various metabolic pathways deeply integrated within mitochondrial functions, the α-ketoglutarate dehydrogenase complex represents a major modulator of electron transport chain activity and tricarboxylic acid cycle (TCA) flux, and is a pivotal enzyme in the metabolic reprogramming following a cancer cell’s change in bioenergetic requirements. By contributing to the control of α-ketoglutarate levels, dynamics, and oxidation state, the α-ketoglutarate dehydrogenase is also essential in modulating the epigenetic landscape of cancer cells. In this review, we will discuss the manifold roles that this TCA enzyme and its substrate play in cancer
Some peculiarities of the population biology of the ghost shrimp Nihonotrypaea petalura (Stimpson, 1860) (Decapoda: Callianassidae) in coastal waters of Vostok bay, the Sea of Japan
No full textWhole exome sequencing revealed novel variants in consanguineous Pakistani families with intellectual disability
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A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer
No full textOrganization of a Unified Coordinate-Information Space to Provide for the Operation of the Multi-Agent Robotic System
No full textHolocene vegetation and hydrology variations and their associations with climate changes: a multi-proxy analysis of a sediment core from an alpine basin in the middle Tianshan Mountains
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