44 research outputs found
Asymmetric Addition of Cyanide to β‐Nitroalkenes Catalysed by Chiral Salen Complexes of Titanium(IV) and Vanadium(V)
No full text
N
No full textRNA-cleaving deoxyribozymes can serve as selective sensors and catalysts to examine the modification state of RNA. However, site-specific endonuclease deoxyribozymes that selectively cleave posttranscriptionally modified RNA are extremely rare and their specificity over unmodified RNA is low. In this study, we report that the native tRNA modification N-isopentenyladenosine (iA) strongly enhances the specificity and has the power to reconfigure the active site of an RNA-cleaving deoxyribozyme. Using in vitro selection, we identified a DNA enzyme that cleaves iA-modified RNA at least 2500-fold faster than unmodified RNA. Another deoxyribozyme shows unique and unprecedented behaviour by shifting its cleavage site in the presence of the iA RNA modification. Together with deoxyribozymes that are strongly inhibited by iA, these results highlight intricate ways of modulating the catalytic activity of DNA by posttranscriptional RNA modifications
The First Highly Enantioselective Homogeneously Catalyzed Asymmetric Reductive Amination: Synthesis of α- N
No full text
Schiff Bases of Amino Acid Esters as New Substrates for the Enantioselective Enzymatic Hydrolysis and Accompanied Asymmetric Transformations in Aqueous Organic Solvents 1
No full textA novel application of the chiral reagent (s)-2-N-(N?benzylprolyl)-aminobenzaldehyde: Synthesis of optically pure ?-methylvaline and ?-methylglutamic acid
No full textAsymmetric synthesis of aspartic and ?-methylaspartic acids via Ni(II) complexes with schiff bases of glycine and alanine and chiral carbonyl-containing reagents
No full textRuHCl(diphosphine)(diamine): Catalyst Precursors for the Stereoselective Hydrogenation of Ketones and Imines 1
No full text
