55 research outputs found
RuCp* Complexes of Ambidentate 4,5-Diazafluorene Derivatives: From Linkage Isomers to Coordination-Driven Self-Assembly
The
coordination chemistry of the {RuCp*}<sup>+</sup> fragment
was studied toward several 4,5-diazafluorene derivatives. The ambidentate
nature of these 4,5-diazafluorene derivatives with multiple coordination
sites allowed for the syntheses of different linkage isomers and self-assembled
macrocycles. Both a tetramer (<b>2</b>) and a monomer (<b>3</b>) of [RuCp*<b>L</b>] (where <b>L</b><sup><b>–</b></sup> = 4,5-diazafluorenide) were prepared with the <b>L</b><sup><b>–</b></sup> ligand. The dimeric head-to-tail
macrocycles [Cp*RuÂ(L<sub>p</sub>H)]<sub>2</sub>Cl<sub>2</sub> (<b>4</b>) and [Cp*RuL<sub>p</sub>]<sub>2</sub> (<b>5</b>) were
obtained with the ditopic <b>L</b><sub><b>p</b></sub><b>H</b> and <b>L</b><sub><b>p</b></sub><sup><b>–</b></sup> ligands (where <b>L</b><sub><b>p</b></sub><b>H</b> = 9-(2-(diphenylphosphino)Âethyl)-4,5-diazafluorene and <b>L</b><sub><b>p</b></sub><sup><b>–</b></sup> = 9-(2-(diphenylphosphino)Âethyl)-4,5-diazafluorenide). The bulky
arene-substituted <b>L</b><sub><b>Mes</b></sub><b>H</b> ligand (where <b>L</b><sub><b>Mes</b></sub><b>H</b> = 3,6-dimesityl-4,5-diazafluorene) was prepared, and its coordination
to {RuCp*}<sup>+</sup> gave [Cp*RuÂ(<b>L</b><sub><b>Mes</b></sub><b>H</b>)]Cl (<b>13</b>). The selective syntheses
of different linkage isomers of [RuCp*Â(<b>L</b><sub><b>Mes</b></sub>)] (<b>14</b> and <b>15</b>) (where <b>L</b><sub><b>Mes</b></sub><sup><b>–</b></sup> = 3,6-dimesityl-4,5-diazafluorenide)
were also demonstrated
Percentage distribution by the Fuhrman grade.
<p>Percentage distribution by the Fuhrman grade.</p
RuCp* Complexes of Ambidentate 4,5-Diazafluorene Derivatives: From Linkage Isomers to Coordination-Driven Self-Assembly
The
coordination chemistry of the {RuCp*}<sup>+</sup> fragment
was studied toward several 4,5-diazafluorene derivatives. The ambidentate
nature of these 4,5-diazafluorene derivatives with multiple coordination
sites allowed for the syntheses of different linkage isomers and self-assembled
macrocycles. Both a tetramer (<b>2</b>) and a monomer (<b>3</b>) of [RuCp*<b>L</b>] (where <b>L</b><sup><b>–</b></sup> = 4,5-diazafluorenide) were prepared with the <b>L</b><sup><b>–</b></sup> ligand. The dimeric head-to-tail
macrocycles [Cp*RuÂ(L<sub>p</sub>H)]<sub>2</sub>Cl<sub>2</sub> (<b>4</b>) and [Cp*RuL<sub>p</sub>]<sub>2</sub> (<b>5</b>) were
obtained with the ditopic <b>L</b><sub><b>p</b></sub><b>H</b> and <b>L</b><sub><b>p</b></sub><sup><b>–</b></sup> ligands (where <b>L</b><sub><b>p</b></sub><b>H</b> = 9-(2-(diphenylphosphino)Âethyl)-4,5-diazafluorene and <b>L</b><sub><b>p</b></sub><sup><b>–</b></sup> = 9-(2-(diphenylphosphino)Âethyl)-4,5-diazafluorenide). The bulky
arene-substituted <b>L</b><sub><b>Mes</b></sub><b>H</b> ligand (where <b>L</b><sub><b>Mes</b></sub><b>H</b> = 3,6-dimesityl-4,5-diazafluorene) was prepared, and its coordination
to {RuCp*}<sup>+</sup> gave [Cp*RuÂ(<b>L</b><sub><b>Mes</b></sub><b>H</b>)]Cl (<b>13</b>). The selective syntheses
of different linkage isomers of [RuCp*Â(<b>L</b><sub><b>Mes</b></sub>)] (<b>14</b> and <b>15</b>) (where <b>L</b><sub><b>Mes</b></sub><sup><b>–</b></sup> = 3,6-dimesityl-4,5-diazafluorenide)
were also demonstrated
Living bacteria inhibited human colonic smooth muscle contraction.
<p>The higher concentration (10<sup>10</sup> CFUs/mL) obviously inhibited human colonic smooth muscle contraction compared with lower contractions (all <i>P</i><0.05). <i>E</i>. <i>faecalis</i> had the strongest inhibition compared with other probiotics (<i>P</i><0.05). N = 6 for each group.</p
Average size of tumor by the Fuhrman grade.
<p>Average size of tumor by the Fuhrman grade.</p
The change trend in increase of case number by Fuhrman grade from 2005 to 2014.
<p>In this figure, the X-axis represents the year from 2005 to 2014; the Y-axis represents number of the case. I: representing Fuhrman grade I; II: representing Fuhrman grade II; III: representing Fuhrman grade III; and IV: representing Fuhrman grade IV.</p
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