Wound healing acceleration in inflammationphase of post-tooth extraction after aerobicand anaerobic exercise

Background: Tooth extraction leads a wound healing that is expected to be physiologicallyhealed in a short time. Both aerobic and anaerobic physical exercises are scientifically provento enhance various biological functions as well as to accelerate the wound healing in oralmucosa. Aerobic exercise increases tissue oxygenation, accelerates the wound healing andthis is different to anaerobic exercise which is considered to produce more free radicals andinterferes the wound healing process. Purpose: To observe the differences of wound healing effectiveness in the inflammatory phaseafter tooth extraction based on the number of PMN and macrophage cells in Wistar rats (Rattusnorvegicus) that received aerobic and anaerobic exercise. Methods: Forty-two rats were divided into three groups: control group (K), aerobic exercisegroup (P1), and anaerobic exercise group (P2). In each group the number of PMN cells wascalculated one day after tooth extraction and the counting of the macrophage cells were per-formed on the other groups two days later. Data was analyzed statistically using Kruskal Wallis,Levene’s test, and proceed with Oneway Anova. Results: The highest number of PMN and macrophage cells was obtained in P1 group and thelowest results were in K group. The data between groups demonstrated significant differences

Increased Levels of Human 8 Defensinsin Childs with Dental Caries

Background: Human Beta Defensin peptide in saliva plays a role as innate immunity to dental caries. The purpose of this study is to determine whether peptide secretion of hBD1,2 and 3 saliva can be used as biological immune response to dental caries. Methods: Unstimulated whole saliva was collected for 55 elementary school students (6-10 years old) at Pondok Pesantren Qomaruddin Gresik, for levels of hBD1,2 and 3 were assessed by ELISA. Salivary pH was measured using digital pH meter. Results: The median hBD1, hBD2 and hBD3 saliva levels for the caries-free group (n = 22) were 0.86 μg / ml, 1.76 μg / ml and 1.88 μg / ml respectively and for the caries group (n = 33) were 5.26 μg / ml, 4.25 μg / ml and 4.85 μg / ml. The result proofs that the Levels of hBD1, hBD2 and hBD3 has a significant correlation with caries experience (p <0.01). The saliva pH in the caries group patient is also more acidic (6.0 - 6.5) than the caries-free group pH (6,9 - 7.0). Conclusion: From the results of this study it can be concluded that the high saliva levels secretion hBD1,2 and 3, can represent the immune response to dental caries and can be used as a new way to prevent dental caries and caries risk assessmen

Correlation Between DMF-T/def-t and The Secretion of Salivary HBD-1 in Carious and Non-Carious Group of Children

Background: DMF-T/deft (Decay Missing Filled Teeth) is an index for assessing dental and oral health status, in this case, dental caries. Dental caries is a multifactorial disease with factors namely teeth and saliva, microorganisms, dietary, and time that affecting each other. Human Beta Defensins-1 (HBD-1) is an Antimicrobial Peptides (AMPs) that has a role as an adaptive immune system in oral health, is a factor that affects the susceptibility and development of dental caries that exhibits activity in Streptococcus mutans bacteria. Objective: To prove the relationship between DMF-T/deft and the levels of HBD-1 saliva secretion in the carious and non-carious groups of children. Method: This study was an observational analytic with cross-sectional study design, with the division of 3 groups namely; group 1 (DMF-T/deft = 0, caries-free), group 2 (DMF-T/deft = 1-3, low caries), and group 3 (DMF-T/deft > 6, high caries). Result: DMF-T/deft index (1,000) obtained HBD-1 concentration (-0.451). Low DMF-T/deft index has high HBD-1 concentration, whereas high DMF-T/deft index has low HBD-1 concentration. The value of p < (0.05) showed there was a significant correlation between the DMF-T/deft index with salivary HBD-1 concentrations. Conclusion: There was a relationship between DMF-T/deft and the level of HBD-1 saliva secretion in the carious and non-carious groups of children