Preparation and characterization of herbal emulsion formulations

WOS: 000417369600003St John's wort extract (Hypericum perforatum L. aerial part extract), marigold extract (Calendula officinalis L. flower extract), wheat germ oil (Triticum vulgare Vill. germ oil) and rose oil (Rosa damascena Mill. volatile oil) have anti-inflammatory, antimicrobial and wound healing properties. In this study, it is aimed to prepare and characterize herbal topical emulsion formulations for skin disorders with these herbal extracts and oils. Initially the compatibility of herbal ingredients was evaluated and the design of formulation as an emulsion was studied. Then decided cream formulations were prepared as o/w type emulsions. The formulations characterized via several parameters such as; macroscopic and microscopic observations, pH, electrical conductivity and rheological measurements. The characterization of prepared three formulations revealed acceptable properties while one of them had better applicability, maintained its macroscopic stability in room conditions for 6 months, had appropriate pH and electrical conductivity values and had pseudoplastic flow properties. As conclusion, a topical emulsion formulation was prepared with appropriate properties

Preparation of allantoin loaded liposome formulations and application for cosmetic textile production

WOS:000631924600001Liposomal systems are suitable for cosmetotextile applications because this system shows topical effect on the skin. Allantoin is a skin active ingredient that has moisturizing and re-epithelization effect. in this work, allantoin loaded liposome formulations were prepared by using the thin film hydration method for textile application. The characterization of liposome formulation was performed by z-average mean polydispersity index, pH, encapsulation efficiency and electrical conductivity. in vitro release of the liposome was performed by dialysis bag method. Selected liposome formulations were applied on polyamide and cotton fabrics by padding and exhaustion methods. Treated fabrics were characterized by release of allantoin from treated fabric, amount of allantoin, determination of formulation loading capacity of fabrics, SEM images and washing durability of liposomes on the fabric surface. Results confirmed a textile product with allantoin loaded liposome could be a good alternative for moisturizing the skin.Scientific and Technological Research Council of Turkey (TUBITAK) projectTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114M031]This project was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) project (Project number: 114M031)

Antioxidant properties evaluation of topical astaxanthin formulations as anti-aging products

WOS: 000457464700037PubMed ID: 29745467Background The reactive oxygen species lead to skin aging via oxidative damage that are induced by UV radiation. Therefore, topical formulations which have antioxidant effect could reduce aging level. Astaxanthin is an antioxidant substance. Aims The aim of this study was to investigate antioxidant activity and cytotoxicity potential of the astaxanthin-loaded gel formulations. Methods Astaxanthin-loaded oleoresin and algae extract were used as natural active materials. The lipogel and hydrogel of these natural materials were prepared as anti-aging formulations. The formulations were characterized via parameters such as, pH, rheological analysis, mechanical properties, and stability. And also in vitro release experiments of the formulations were carried out. The antioxidant activity and cytotoxicity test were performed. Results The results of characterization studies confirmed the formulations suitable for topical application. After 24 hours, 99 mu g, 88.3 mu g, 403 mu g, and 234.8 mu g of astaxanthin released through oleoresin lipogel, oleoresin hydrogel, algae extract lipogel, and algae extract hydrogel, respectively. It was found by the cytotoxicity tests that astaxanthin is more proliferative in lipogel formulations compared to hydrogel formulations. And finally, the highest antioxidant activity was found in the algae extract hydrogel and algae extract lipogel formulation, respectively (P < .05). Conclusions Topical formulations of astaxanthin-loaded oleoresin and algae extract were prepared successfully. At the same time, according to antioxidant activity and release studies, algae extract loaded could be suggested as topical anti-aging formulations.Scientific Research Projects (BAP) commission of Ege UniversityScientific Research Projects (BAP) commission of Ege Universit

Preparation and in vitro evaluation of melatonin-loaded HA/PVA gel formulations

WOS: 000445486600009PubMed ID: 27915492Melatonin-loaded hyaluronic acid (HA) and poly(vinyl alcohol) (PVA) gels were prepared by using freeze-thaw technique and an emulsion method followed by freeze-thaw technique to produce a new synergistic system for topical application. Freeze-thaw hydrogels and emulgels were characterized by means of Fourier transform infrared spectroscopy, rheology and swelling tests. The porous structure of the hydrogels was shown by scanning electron microscopy observations and thermal properties were tested by differential scanning calorimetry measurements. Bioadhesion and in vitro release characterization of formulations were performed by texture profile analysis and dialysis bag method, respectively. The pore size of both formulations was ranging from 900nm to 30m. Melatonin showed a good compatibility with the polymeric matrices as the pores were smaller for the drug-loaded systems. In vitro release studies showed that the release was improved by emulgel formulations. After 24h, the release percentage was found to be 13.240%+/- 1.094 and 15.192%+/- 2.270 for hydrogel and emulgel, respectively. Emulgels had better bioadhesion properties than simple freeze-thaw samples. As a conclusion, regarding the in vitro characterization studies HA and PVA hydrogel and emulgel formulations and their lyophilized forms could be promising systems for topical application of melatonin