Synthesis of novel tetrahydroindeno[1,2-<i>b</i>]pyrrolidines via Ugi multicomponent and palladium-catalyzed aerobic oxidative cyclization

<p>Novel tetrahydroindeno[1,2-<i>b</i>]pyrrolidines were conveniently prepared in moderate to good yields via a sequential Ugi multicomponent reaction or Staudinger/aza-Wittig/Ugi combination, followed by the palladium-catalyzed aerobic oxidative cyclization of the resulting Ugi adducts.</p