5 research outputs found
Methyl-α‑d‑2-selenonyl Pent-2-enofuranoside: A Reactive Selenosugar for the Diversity Oriented Synthesis of Enantiomerically Pure Heterocycles, Carbocycles, and Isonucleosides
The construction of vinyl selenone
on a furanoside led to a highly
reactive synthetic intermediate methyl-α-d-2-selenonyl
pent-2-enofuranoside composed of a masked aldehyde, an electron-deficient
double bond along with an excellent leaving group. This new Michael
acceptor on reactions with different nucleophiles afforded bicyclic
azasugars, cyclopropanated carbohydrate, dihydrofuran- and dihydroisoxazole-
substituted furanosides, and isonucleosides in moderate to good yields.
Hydrolysis of the hemiacetal linkage of some of these modified carbohydrates
afforded enantiopure aziridines, nitrocyclopropane, and dihydrofuran
1,5‑Disubstituted 1,2,3-Triazolylation at C1, C2, C3, C4, and C6 of Pyranosides: A Metal-Free Route to Triazolylated Monosaccharides and Triazole-Linked Disaccharides
A pair of easily accessible vinyl
sulfones derived from styrene
epoxide and monotosylated glycerol were reacted with six different
azidopyranosides having an azido group at C1, C2, C3, C4, C6, and
at the terminal position of an exocylic chain attached to C1. The
reaction was performed mostly in water at elevated temperature without
any metal catalyst to afford regioselectively 1,5-disubstituted triazolylated
pyranosides in high yields. Another set of exocyclic vinyl sulfones
prepared from 3-<i>O</i>-methylated- and 3-<i>O</i>-benzylated glucofuranosides as well as 3-<i>O</i>-benzylated
allofuranoside were also subjected to 1,3-dipolar cycloaddition reactions
with six azidopyranosides under similar reaction conditions to generate
a series of 1,5-disubstituted triazole-linked disaccharides. The synthesis
of all 1,5-disubstituted triazolylated monosaccharides as well as
all 1,5-disubstituted triazole linked disaccharides are reported for
the first time. Steric bulk around the azido and vinyl sulfone groups
plays a significant role in deciding the outcome of the reactions.
This powerful and practical route has the potential to be exploited
for the synthesis of complex 1,5-disubstituted 1,2,3-triazolylated
carbohydrates
Methyl-α‑d‑2-selenonyl Pent-2-enofuranoside: A Reactive Selenosugar for the Diversity Oriented Synthesis of Enantiomerically Pure Heterocycles, Carbocycles, and Isonucleosides
The construction of vinyl selenone
on a furanoside led to a highly
reactive synthetic intermediate methyl-α-d-2-selenonyl
pent-2-enofuranoside composed of a masked aldehyde, an electron-deficient
double bond along with an excellent leaving group. This new Michael
acceptor on reactions with different nucleophiles afforded bicyclic
azasugars, cyclopropanated carbohydrate, dihydrofuran- and dihydroisoxazole-
substituted furanosides, and isonucleosides in moderate to good yields.
Hydrolysis of the hemiacetal linkage of some of these modified carbohydrates
afforded enantiopure aziridines, nitrocyclopropane, and dihydrofuran
Enantiopure 1,4,5-Trisubstituted 1,2,3-Triazoles from Carbohydrates: Applications of Organoselenium Chemistry
A wide range of stable vinyl selenone-modified
furanosides has
been synthesized for the first time. These 2Ï€-partners undergo
1,3-dipolar cycloaddition reactions with a wide range of organic azides
to afford enantiopure trisubstituted triazoles. Furanosyl rings opened
up during triazole synthesis to generate polyfunctionalized molecules,
ready to undergo further transformations. This strategy is one of
the most convenient methods for the synthesis of enantiopure 1,4,5-trisubstituted
1,2,3-triazoles where the chiral components are attached to C-4 or
C-5 position of triazole ring. These triazoles are formed in a regioselective
manner, and several pairs of regioisomeric triazoles have also been
synthesized. The approach affords densely functionalized triazoles,
which are amenable to further modifications because of the presence
of aldehyde and hydroxyl groups. This powerful and practical route
adds to the arsenals of chemists and biologists interested in the
synthesis and applications of triazoles
Regioselectivity of Vinyl Sulfone Based 1,3-Dipolar Cycloaddition Reactions with Sugar Azides by Computational and Experimental Studies
DFT (M06-L) calculations on the transition
state for the 1,3-dipolar
cycloadditions between substituted vinyl sulfones with sugar azide
have been reported in conjunction with new experimental results, and
the origin of reversal of regioselectivity has been revealed using
a distortion/interaction model. This study provides the scientific
justification for combining organic azides with two different types
of vinyl sulfones for the preparation of 1,5-disubstituted 1,2,3-triazoles
and 1,4-disubstituted triazolyl esters under metal-free conditions