5 research outputs found
Reducing Energy Consumption by Optimizing Thermal Losses and Measures of Energy Recovery in Preschools
Genetic alterations in quadruple malignancies of a patient with multiple sclerosis: their role in malignancy development and response to therapy
Multiple cancers represent 2.42\% of all human cancers and are mainly
double or triple cancers. Many possible causes of multiple malignancies
have been reported such as genetic alterations, exposure to anti-cancer
chemotherapy, radiotherapy, immunosuppressive therapy and reduced
immunologic response. We report a female patient with multiple sclerosis
and quadruple cancers of different embryological origin. Patient was
diagnosed with stage III (T3, N1a, MO) medullary thyroid carcinoma
(MTC), multicentric micropapillary thyroid carcinoma, scapular and
lumbar melanomas (Clark II, Breslow II), and lobular invasive breast
carcinoma (T1a, NO, MO). All tumors present in our patient except
micropapillary thyroid carcinomas were investigated for gene alterations
known to have a key role in cancer promotion and progression. Tumor
samples were screened for the p16 alterations (loss of heterozygosity
and homozygous deletions), loss of heterozygosity of PTEN, p53
alterations (mutational status and loss of heterozygosity) and
mutational status of RET, HRAS and KRAS. Each type of tumor investigated
had specific pattern of analyzed genetic alterations. The most prominent
genetic changes were mutual alterations in PTEN and p53 tumor
suppressors present in breast cancer and two melanomas. These
co-alterations could be crucial for promoting development of multiple
malignancies. Moreover the insertion in 4th codon of HRAS gene was
common for all tumor types investigated. It represents frameshift
mutation introducing stop codon at position 5 which prevents synthesis
of a full-length protein. Since the inactivated RAS enhances sensitivity
to tamoxifen and radiotherapy this genetic alteration could be
considered as a good prognostic factor for this patient.Ministry of Education, Science and Technological Development of the
Republic of Serbia {[}III41031
Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
PURPOSE: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles.
MATERIALS AND METHODS: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies).
RESULTS: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129-0.278; p\u3c0.001; I²=83.62%, Egger\u27s p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474-1.706; p\u3c0.001; I²=97.86%, Egger\u27s p\u3c0.0001; total sperm count: SMD 1.824, 95% CI: 1.526-2.121; p\u3c0.001; I²=97.88%, Egger\u27s p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318-1.968; p\u3c0.001; I²=98.65%, Egger\u27s p=0.0003; progressive sperm motility: SMD 1.845, 95% CI: 1.537%-2.153%; p\u3c0.001; I²=98.97%, Egger\u27s p\u3c0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%-1.759%; p\u3c0.001; l2=97.98%, Egger\u27s p\u3c0.001; sperm morphology: SMD 1.066, 95% CI 0.992%-1.211%; p\u3c0.001; I²=97.87%, Egger\u27s p=0.1864.
CONCLUSIONS: The current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele
Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
Purpose: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles. Materials and Methods: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies). Results: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were includ-ed in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129-0.278; p<0.001; I2=83.62%, Egger's p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474-1.706; p<0.001; I2=97.86%, Egger's p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526-2.121; p<0.001; I2=97.88%, Egger's p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318-1.968; p<0.001; I2=98.65%, Egger's p=0.0003; progressive sperm motil-ity: SMD 1.845, 95% CI: 1.537%-2.153%; p<0.001; I2=98.97%, Egger's p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%-1.759%; p<0.001; l2=97.98%, Egger's p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%-1.211%; p<0.001; I2=97.87%, Egger's p=0.1864. Conclusions: The current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele
Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
International audiencePurpose: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles.Materials and methods: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies).Results: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129-0.278; p<0.001; I²=83.62%, Egger's p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474-1.706; p<0.001; I²=97.86%, Egger's p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526-2.121; p<0.001; I²=97.88%, Egger's p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318-1.968; p<0.001; I²=98.65%, Egger's p=0.0003; progressive sperm motility: SMD 1.845, 95% CI: 1.537%-2.153%; p<0.001; I²=98.97%, Egger's p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%-1.759%; p<0.001; l2=97.98%, Egger's p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%-1.211%; p<0.001; I²=97.87%, Egger's p=0.1864.Conclusions: The current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele