A High Phase Detection Density and Low Space Complexity Mueller-Muller Phase Detector for DB PAM-4 Wireline Receiver

A Mueller-Muller Phase Detector (MM PD) technology based on duo-binary four-level pulse amplitude modulation (DB PAM-4) with low complexity and high phase-detection density is presented. The proposed low complexity includes low phase-detection complexity and low space complexity of data processing. The waveform sifting technology simplifies 175 specific waveform changes into five fuzzy waveform change trends, reducing the complexity of subsequent phase detection. By making the data sample before the waveform sifting, the data bit width is reduced from 8 bit to 3 bit, which realizes data dimensionality reduction, greatly reduces the scale of subsequent auxiliary data, reduces the number of basic devices by 13.7%, and reduces the spatial complexity of data processing. The coherent coding of DB PAM-4 combined with waveform sifting increases the phase-detection density from 50% to 65% and improves both phase-detection density and phase-detection gain by 30%, and improves the jitter tolerance. Through the simulation of the clock and data recovery (CDR) model built by Cadence, the fast locking capability of CDR is verified

A 112 Gb/s DAC-Based Duo-Binary PAM4 Transmitter in 28 nm CMOS

To reduce the high bit error rate of serial transceivers under strong channel attenuation, a low-power 112 Gb/s SerDes transmitter was designed using a duo-binary PAM4 modulation technology. By adopting duo-binary PAM4 modulation technology, the problem of the low bandwidth utilization of a high-speed PAM4 (pulse amplitude modulation 4) signal was improved. The problem of high jitter caused by charge sharing and the limited bandwidth of a 4:1 high-speed MUX was improved by using precharging auxiliary transistors. The system power consumption of the transmitter was reduced by using a 7-bit weighted voltage-driven digital-to-analog converter (DAC). The transmitter was designed with a 28 nm CMOS process and powered by a voltage of 0.9 V. The simulation results showed that when the channel attenuation was 20.9 dB, the transmitter could work at 112 Gb/s, the power consumption was 2.02 pJ/bit, and the linearity was 96.7%

A 112 Gb/s DAC-Based Duo-Binary PAM4 Transmitter in 28 nm CMOS

To reduce the high bit error rate of serial transceivers under strong channel attenuation, a low-power 112 Gb/s SerDes transmitter was designed using a duo-binary PAM4 modulation technology. By adopting duo-binary PAM4 modulation technology, the problem of the low bandwidth utilization of a high-speed PAM4 (pulse amplitude modulation 4) signal was improved. The problem of high jitter caused by charge sharing and the limited bandwidth of a 4:1 high-speed MUX was improved by using precharging auxiliary transistors. The system power consumption of the transmitter was reduced by using a 7-bit weighted voltage-driven digital-to-analog converter (DAC). The transmitter was designed with a 28 nm CMOS process and powered by a voltage of 0.9 V. The simulation results showed that when the channel attenuation was 20.9 dB, the transmitter could work at 112 Gb/s, the power consumption was 2.02 pJ/bit, and the linearity was 96.7%

A case of SLE with COVID-19 and multiple infections

The coronavirus disease 2019 (COVID-19) has become a global pandemic, which is induced by infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with systemic lupus erythematosus (SLE) are susceptible to infections due to the chronic use of immunosuppressive drugs and the autoimmune disorders. Now we report a case of SLE infected with SARS-CoV-2, influenza A virus and Mycoplasma pneumoniae concurrently. The patient used hydroxychloroquine and prednisone chronically to control the SLE. After infection of SARS-CoV-2, she was given higher dose of prednisone than before and the same dosage of hydroxychloroquine. Besides, some empirical treatments such as antiviral, antibiotic and immunity regulating therapies were also given. The patient finally recovered from COVID-19. This case indicated that hydroxychloroquine may not be able to fully protect SLE patient form SARS-CoV-2. Intravenous immunoglobulin therapies and increased dose of corticosteroids might be adoptable for patient with both COVID-19 and SLE. Physicians should consider SARS-CoV-2 virus test when SLE patient presented with suspected infection or SLE flare under the epidemic of COVID-19

Optimization Design of Laser Arrays Based on Absorption Spectroscopy Imaging for Detecting Temperature and Concentration Fields

Detecting temperature and concentration fields within engine combustors holds paramount significance in enhancing combustion efficiency and ensuring operational safety. Within the realm of engine combustors, the laminar absorption spectroscopy technique has garnered considerable attention. Particularly crucial is the optimization of the optical path configuration to enhance the efficacy of reconstruction. This study presents a flame parameter field reconstruction model founded on laminar absorption spectroscopy. Furthermore, an optimization approach for refining the optical path configuration is delineated. In addressing non-axisymmetric flames, the simulated annealing algorithm (SA) and Harris’s Hawk algorithm (HHO) are employed to optimize the optical path layout across varying beam quantities. The findings underscore a marked reduction in imaging errors with the optimized optical path configuration compared to conventional setups, thereby elevating detection precision. Notably, the HHO algorithm demonstrates superior performance over the SA algorithm in terms of optimization outcomes and computational efficiency. Compared with the parallel optical path, the optimized optical path of the HHO algorithm reduces the temperature field error by 25.5% and the concentration field error by 26.5%

Young Cervical Cancer Patients May Be More Responsive than Older Patients to Neoadjuvant Chemotherapy Followed by Radical Surgery.

OBJECTIVE:To evaluate the effects of age and the clinical response to neoadjuvant chemotherapy (NACT) in patients with cervical cancer who received neoadjuvant chemotherapy followed by radical surgery. METHODS:A total of 1,014 patients with advanced cervical cancer who received NACT followed by radical surgery were retrospectively selected. Patients were divided into young (aged ≤35 years, n = 177) and older (aged >35 years, n = 837) groups. We compared the short-term responses and survival rates between the groups. The five-year disease-free survival (DFS) and overall survival (OS) rates were stratified by age, NACT response, and FIGO stage. RESULTS:The overall response rate was 86.8% in the young group and 80.9% in the older group. The young patients had an earlier FIGO stage (P<0.001), a higher rate of adenocarcinoma (P = 0.022), and more lymph node metastasis (P = 0.033) than the older patients. The presence of adenocarcinoma as the histological type (P = 0.024) and positive lymph node metastasis (P<0.001) were identified as independent risk factors for survival. When stratified by age and clinical response, young patients with no response to NACT had a worse clinicopathological condition compared with the other subgroups. Compared with non-responders, responders to NACT had a higher five-year DFS rate (80.1% versus 71.8%; P = 0.019) and OS rate (82.6% versus 71.8%; P = 0.003) among the young patients but not among the older patients. CONCLUSIONS:Responders to NACT aged 35 years or younger benefitted the most from NACT, while the young non-responders benefitted the least. Age might represent an important factor to consider when performing NACT in patients with cervical cancer

The predictive value of serum squamous cell carcinoma antigen in patients with cervical cancer who receive neoadjuvant chemotherapy followed by radical surgery: a single-institute study.

Neoadjuvant chemotherapy (NACT) could affect the levels of squamous cell carcinoma antigen (SCC-Ag). This study evaluates the predictive value of pre- and posttreatment SCC-Ag levels in patients with cervical cancer who were treated with NACT followed by radical surgery.A total of 286 patients with Stage IB1-IIIB squamous cell carcinoma of the uterine cervix who were treated with NACT followed by radical hysterectomy were analyzed retrospectively. The relationship between SCC-Ag levels, the clinicopathologic parameters, the response to NACT and the three-year survival rate was investigated.The levels of SCC-Ag were elevated (>3.5 ng/mL) in 43.8% of patients before NACT, and 13.0% of patients after NACT. Pre- and posttreatment levels of SCC-Ag correlated with the response to NACT (P = 0.010, and P3.5 ng/mL (P3.5 ng/mL) indicated a poor response to NACT and a higher risk of lymph node metastases. Elevated posttreatment levels of SCC-Ag were correlated with poor DFS and OS