3,436 research outputs found
Direct reconstruction of dynamical dark energy from observational Hubble parameter data
Reconstructing the evolution history of the dark energy equation of state
parameter directly from observational data is highly valuable in
cosmology, since it contains substantial clues in understanding the nature of
the accelerated expansion of the Universe. Many works have focused on
reconstructing using Type Ia supernova data, however, only a few studies
pay attention to Hubble parameter data. In the present work, we explore the
merit of Hubble parameter data and make an attempt to reconstruct from
them through the principle component analysis approach. We find that current
Hubble parameter data perform well in reconstructing ; though, when
compared to supernova data, the data are scant and their quality is worse. Both
CDM and evolving models can be constrained within at
redshifts
and even at redshifts 0.1 z 1 by
using simulated data of observational quality.Comment: 25 pages, 11 figure
microRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma.
Glycolysis was reported to have a positive correlation with radioresistance. Our previous study found that the miR-33a functioned as a tumor suppressor in malignant melanoma by targeting hypoxia-inducible factor1-alpha (HIF-1α), a gene known to promote glycolysis. However, the role of miR-33a-5p in radiosensitivity remains to be elucidated. We found that miR-33a-5p was downregulated in melanoma tissues and cells. Cell proliferation was downregulated after overexpression of miR-33a-5p in WM451 cells, accompanied by a decreased level of glycolysis. In contrast, cell proliferation was upregulated after inhibition of miR-33a-5p in WM35 cells, accompanied by increased glycolysis. Overexpression of miR-33a-5p enhanced the sensitivity of melanoma cells to X-radiation by MTT assay, while downregulation of miR-33a-5p had the opposite effects. Finally, in vivo experiments with xenografts in nude mice confirmed that high expression of miR-33a-5p in tumor cells increased radiosensitivity via inhibiting glycolysis. In conclusions, miR-33a-5p promotes radiosensitivity by negatively regulating glycolysis in melanoma
Bose-Einstein condensation on an atom chip
We report an experiment of creating Bose-Einstein condensate (BEC) on an atom
chip. The chip based Z-wire current and a homogeneous bias magnetic field
create a tight magnetic trap, which allows for a fast production of BEC. After
an 4.17s forced radio frequency evaporative cooling, a condensate with about
3000 atoms appears. And the transition temperature is about 300nK. This compact
system is quite robust, allowing for versatile extensions and further studying
of BEC.Comment: 5 pages, 6 figure
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