Direct reconstruction of dynamical dark energy from observational Hubble parameter data

Reconstructing the evolution history of the dark energy equation of state parameter $w(z)$ directly from observational data is highly valuable in cosmology, since it contains substantial clues in understanding the nature of the accelerated expansion of the Universe. Many works have focused on reconstructing $w(z)$ using Type Ia supernova data, however, only a few studies pay attention to Hubble parameter data. In the present work, we explore the merit of Hubble parameter data and make an attempt to reconstruct $w(z)$ from them through the principle component analysis approach. We find that current Hubble parameter data perform well in reconstructing $w(z)$; though, when compared to supernova data, the data are scant and their quality is worse. Both $\Lambda$CDM and evolving $w(z)$ models can be constrained within $10\%$ at redshifts $z \lesssim 1.5$ and even $5\%$ at redshifts 0.1 $\lesssim$ z $\lesssim$ 1 by using simulated $H(z)$ data of observational quality.Comment: 25 pages, 11 figure

microRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma.

Glycolysis was reported to have a positive correlation with radioresistance. Our previous study found that the miR-33a functioned as a tumor suppressor in malignant melanoma by targeting hypoxia-inducible factor1-alpha (HIF-1α), a gene known to promote glycolysis. However, the role of miR-33a-5p in radiosensitivity remains to be elucidated. We found that miR-33a-5p was downregulated in melanoma tissues and cells. Cell proliferation was downregulated after overexpression of miR-33a-5p in WM451 cells, accompanied by a decreased level of glycolysis. In contrast, cell proliferation was upregulated after inhibition of miR-33a-5p in WM35 cells, accompanied by increased glycolysis. Overexpression of miR-33a-5p enhanced the sensitivity of melanoma cells to X-radiation by MTT assay, while downregulation of miR-33a-5p had the opposite effects. Finally, in vivo experiments with xenografts in nude mice confirmed that high expression of miR-33a-5p in tumor cells increased radiosensitivity via inhibiting glycolysis. In conclusions, miR-33a-5p promotes radiosensitivity by negatively regulating glycolysis in melanoma

Bose-Einstein condensation on an atom chip

We report an experiment of creating Bose-Einstein condensate (BEC) on an atom chip. The chip based Z-wire current and a homogeneous bias magnetic field create a tight magnetic trap, which allows for a fast production of BEC. After an 4.17s forced radio frequency evaporative cooling, a condensate with about 3000 atoms appears. And the transition temperature is about 300nK. This compact system is quite robust, allowing for versatile extensions and further studying of BEC.Comment: 5 pages, 6 figure