Osteocalcin has a muscle-protective effect during weight loss in men without metabolic syndrome: a multicenter, prospective, observational study

ObjectiveWeight reduction often accompanies muscle loss. Existing studies highlight the involvement of osteocalcin (OC) in energy metabolism and its potential to prevent age-related muscle loss. Nevertheless, these studies predominantly involve individuals with hyperglycemia, yielding conflicting research outcomes. This study investigated the protective role of OC against muscle loss during weight reduction in individuals without metabolic syndrome (MetS).MeasuresWe enrolled 130 overweight or obese individuals without MetS in a 4-month high-protein, energy-restricted dietary weight management program conducted at two clinic centers. Body composition and laboratory tests were assessed both before and after weight loss. Correlation and regression analysis were made between the changes in metabolic indicators and muscle mass during weight loss.ResultsFollowing weight loss, there was a decrease in body mass index (BMI), percentage of body fat (PBF), visceral fat area (VFA), fasting insulin (FINS), homeostasis model assessment insulin resistance (HOMA-IR), glycated haemoglobin (HbA1c), and lipid profile, and increase in the percentage of skeletal muscle (PSM) and vitamin D. There was no change in osteocalcin (OC) during the intervention. Correlation analysis of the relative changes in all metabolic indicators revealed a positive correlation between OC and PSM (r=0.383, p=0.002). Multiple linear regression analysis found that OC has a significant protective effect on muscles during weight loss in males after adjusting for confounding factors (β=0.089, p=0.017).ConclusionHigh-protein, energy-restricted diets demonstrate efficacy in enhancing metabolic indicators within the weight-loss population. Furthermore, OC exhibits a protective effect on muscle mass during weight reduction in individuals without MetS, with this effect being particularly evident in males

Circulating magnesium levels and incidence of coronary heart diseases, hypertension, and type 2 diabetes mellitus: a meta-analysis of prospective cohort studies

Abstract Background Data on the associations between circulating magnesium (Mg) levels and incidence of coronary heart diseases (CHD), hypertension, and type 2 diabetes mellitus (T2DM) are inconsistent and inconclusive. The aim of this study was to examine circulating Mg levels in relation to incidence of CHD, hypertension, and T2DM. Methods Prospective cohort studies published before May 2017 were searched through PubMed, EmBase, SCOPUS, and Google Scholar. A total of 11 studies that reported multivariable-adjusted associations of interest were identified. Information on the characteristics of study and participants, exposure, main outcomes, risk estimates, and cofounders was extracted and analyzed. Results Of the 11 included studies, 5 reported results on CHD (38,808 individuals [4437 cases] with an average 10.5-year follow-up), 3 on hypertension (14,876 participants [3149 cases] with a 6.7-year follow-up), and 4 on T2DM (31,284 participants [2680 cases] with an 8.8-year follow-up). Comparing the highest to the lowest category of circulating Mg concentration, the pooled relative risks [RRs] (95% confidence intervals [CIs]) were 0.86 (0.74, 0.996), 0.91 (0.80, 1.02), and 0.64 (0.50, 0.81) for incidence of CHD, hypertension, and T2DM, respectively. Every 0.1 mmol/L increment in circulating Mg levels was associated with 4% (RR, 0.96; 95% CI: 0.94, 0.99) reduction in hypertension incidence. No significant linear association was found between circulating Mg levels and incidence of CHD (RR, 0.89; 95% CI: 0.77, 1.03) and T2DM (RR, 0.90; 95% CI: 0.81, 1.002). The observed associations of interest were sensitive to exclusion of individual studies. Conclusions Findings in this meta-analysis suggest that circulating Mg levels are inversely associated with incidence of CHD, hypertension, and T2DM. Additional studies are needed to provide more solid evidence and identify the optimal range of circulating Mg concentration with respect to primary prevention of CHD, hypertension, and T2DM

The Effects of Choline on Hepatic Lipid Metabolism, Mitochondrial Function and Antioxidative Status in Human Hepatic C3A Cells Exposed to Excessive Energy Substrates

Choline plays a lipotropic role in lipid metabolism as an essential nutrient. In this study, we investigated the effects of choline (5, 35 and 70 μM) on DNA methylation modifications, mRNA expression of the critical genes and their enzyme activities involved in hepatic lipid metabolism, mitochondrial membrane potential (Δψm) and glutathione peroxidase (GSH-Px) in C3A cells exposed to excessive energy substrates (lactate, 10 mM; octanoate, 2 mM and pyruvate, 1 mM; lactate, octanoate and pyruvate-supplemented medium (LOP)). Thirty five micromole or 70 μM choline alone, instead of a low dose (5 μM), reduced hepatocellular triglyceride (TG) accumulation, protected Δψm from decrement and increased GSH-Px activity in C3A cells. The increment of TG accumulation, reactive oxygen species (ROS) production and Δψm disruption were observed under LOP treatment in C3A cells after 72 h of culture, which were counteracted by concomitant treatment of choline (35 μM or 70 μM) partially via reversing the methylation status of the peroxisomal proliferator-activated receptor alpha (PPARα) gene promoter, upregulating PPARα, carnitine palmitoyl transferase-I (CPT-I) and downregulating fatty acid synthase (FAS) gene expression, as well as decreasing FAS activity and increasing CPT-I and GSH-Px activities. These findings provided a novel insight into the lipotropic role of choline as a vital methyl-donor in the intervention of chronic metabolic diseases

Table1_Seismological reference earth model in South China (SREM-SC): Crust and uppermost mantle.XLSX

The South China Block is located on the eastern margin of the Eurasian Plate and the western margin of the Pacific Plate. The South China Block is currently in a tectonically compressed environment, while the Tibetan Plateau is moving eastward and the Philippine Sea Plate is moving westward from geodetic observations. The South China Block is an ideal place to revisit tectonic history from the Archean to Cenozoic, where its information could be well preserved in the crust. In this study, we aim to build the crustal and uppermost mantle component of the Seismological Reference Earth Model in South China (SREM-SC) to provide a background velocity model for geological interpretations and fine-scale velocity inversion. The S-wave velocity model comes from combining models inverted by ambient noise tomography and surface wave tomography. The P-wave velocity model is obtained from converted S-wave velocity and joint inversion tomography. The density model is inferred from an empirical relationship with P-wave velocity. The Moho depth is obtained by a weighted averaging scheme of previously published receiver function results. The P-wave and S-wave velocity models have a grid interval of 0.5° in both latitude and longitude, and with a vertical sampling interval of 5 km down to the 60 km depth. This work provides the 3-D crust and uppermost mantle structures and a representative reference model beneath South China.</p

DataSheet1_Seismological reference earth model in South China (SREM-SC): Crust and uppermost mantle.PDF

The South China Block is located on the eastern margin of the Eurasian Plate and the western margin of the Pacific Plate. The South China Block is currently in a tectonically compressed environment, while the Tibetan Plateau is moving eastward and the Philippine Sea Plate is moving westward from geodetic observations. The South China Block is an ideal place to revisit tectonic history from the Archean to Cenozoic, where its information could be well preserved in the crust. In this study, we aim to build the crustal and uppermost mantle component of the Seismological Reference Earth Model in South China (SREM-SC) to provide a background velocity model for geological interpretations and fine-scale velocity inversion. The S-wave velocity model comes from combining models inverted by ambient noise tomography and surface wave tomography. The P-wave velocity model is obtained from converted S-wave velocity and joint inversion tomography. The density model is inferred from an empirical relationship with P-wave velocity. The Moho depth is obtained by a weighted averaging scheme of previously published receiver function results. The P-wave and S-wave velocity models have a grid interval of 0.5° in both latitude and longitude, and with a vertical sampling interval of 5 km down to the 60 km depth. This work provides the 3-D crust and uppermost mantle structures and a representative reference model beneath South China.</p

Hip circumference has independent association with the risk of hyperuricemia in middle-aged but not in older male patients with type 2 diabetes mellitus

Abstract Background Obesity and type 2 diabetes mellitus (T2DM) are risk factors for hyperuricemia. However, which anthropometric indices can better predict incident hyperuricemia in patients with T2DM remains inconsistent. This study aimed to examine the associations between hyperuricemia and different anthropometric indices in middle-aged and older male patients with T2DM. Methods In this retrospective study, a total of 1447 middle-aged (45—65 years, n = 791) and older (≥ 65 years, n = 656) male patients with T2DM were collected from December 2015 to January 2020 at Shanghai Xinhua Hospital. Hyperuricemia was defined as a serum uric acid level above 7.0 mg/dL. Weight, height, waist circumference (WC) and hip circumference (HC) were measured by trained nurses at visit. Results The median uric acid level of subjects was 5.6 (interquartile ranges: 4.7—6.7) mg/dl, and 279 (19.3%) were hyperuricemia, with 146 (18.5%) in the middle-aged group, and 133 (20.3%) in the older group. After adjusting for age, duration of T2DM, fasting plasma glucose and insulin, homeostasis model assessment-β, aspartate aminotransferase, triglycerides, high-density lipoprotein cholesterol and estimated glomerular filtration rate, body mass index (BMI), WC, HC, and waist-to-height ratio (WHtR) were associated with a higher risk of hyperuricemia in both middle-aged and older group (P < 0.05). After further adjusting for BMI and WC, HC still showed a positive relationship with the risk of hyperuricemia (Odds Ratio = 1.51, 95% confidence intervals: 1.06—2.14) in the middle-aged group, but such relationship was not found in the older group. Moreover, according to receiver operating characteristic analysis, the optimal cutoff value was 101.3 cm of HC for hyperuricemia screening in the middle-aged male patients with T2DM. Conclusion In middle-aged male patients with T2DM, more attention should be paid to HC with the cutoff value of 101.3 cm in clinical practice for early recognition of individuals with a high risk of hyperuricemia for targeted guidance on disease prevention, such as community screening

Table2_Seismological reference earth model in South China (SREM-SC): Crust and uppermost mantle.XLSX

The South China Block is located on the eastern margin of the Eurasian Plate and the western margin of the Pacific Plate. The South China Block is currently in a tectonically compressed environment, while the Tibetan Plateau is moving eastward and the Philippine Sea Plate is moving westward from geodetic observations. The South China Block is an ideal place to revisit tectonic history from the Archean to Cenozoic, where its information could be well preserved in the crust. In this study, we aim to build the crustal and uppermost mantle component of the Seismological Reference Earth Model in South China (SREM-SC) to provide a background velocity model for geological interpretations and fine-scale velocity inversion. The S-wave velocity model comes from combining models inverted by ambient noise tomography and surface wave tomography. The P-wave velocity model is obtained from converted S-wave velocity and joint inversion tomography. The density model is inferred from an empirical relationship with P-wave velocity. The Moho depth is obtained by a weighted averaging scheme of previously published receiver function results. The P-wave and S-wave velocity models have a grid interval of 0.5° in both latitude and longitude, and with a vertical sampling interval of 5 km down to the 60 km depth. This work provides the 3-D crust and uppermost mantle structures and a representative reference model beneath South China.</p

Effect of Decaffeinated Green Tea Polyphenols on Body Fat and Precocious Puberty in Obese Girls: A Randomized Controlled Trial

Background: Obesity has been reported to be an important contributing factor for precocious puberty, especially in girls. The effect of green tea polyphenols on weight reduction in adult population has been shown, but few related studies have been conducted in children. This study was performed to examine the effectiveness and safety of decaffeinated green tea polyphenols (DGTP) on ameliorating obesity and early sexual development in girls with obesity. Design: This is a double-blinded randomized controlled trial. Girls with obesity aged 6–10 years old were randomly assigned to receive 400 mg/day DGTP or isodose placebo orally for 12 weeks. During this period, all participants received the same instruction on diet and exercise from trained dietitians. Anthropometric measurements, secondary sexual characteristics, B-scan ultrasonography of uterus, ovaries and breast tissues, and related biochemical parameters were examined and assessed pre- and post-treatment. Results: Between August 2018 and January 2020, 62 girls with obesity (DGTP group n = 31, control group n = 31) completed the intervention and were included in analysis. After the intervention, body mass index, waist circumference, and waist-to-hip ratio significantly decreased in both groups, but the percentage of body fat (PBF), serum uric acid (UA), and the volumes of ovaries decreased significantly only within the DGTP group. After controlling confounders, DGTP showed a significantly decreased effect on the change of PBF (β = 2.932, 95% CI: 0.214 to 5.650), serum UA (β = 52.601, 95% CI: 2.520 to 102.681), and ovarian volumes (right: β = 1.881, 95% CI: 0.062 to 3.699, left: β = 0.971, 95% CI: 0.019 to 1.923) in girls with obesity. No side effect was reported in both groups during the whole period. Conclusion: DGTP have shown beneficial effects of ameliorated obesity and postponed early sexual development in girls with obesity without any adverse effects. Clinical Trial Registration: [https://clinicaltrials.gov/ct2/show/NCT03628937], identifier [NCT03628937]

Table3_Seismological reference earth model in South China (SREM-SC): Crust and uppermost mantle.XLSX

The South China Block is located on the eastern margin of the Eurasian Plate and the western margin of the Pacific Plate. The South China Block is currently in a tectonically compressed environment, while the Tibetan Plateau is moving eastward and the Philippine Sea Plate is moving westward from geodetic observations. The South China Block is an ideal place to revisit tectonic history from the Archean to Cenozoic, where its information could be well preserved in the crust. In this study, we aim to build the crustal and uppermost mantle component of the Seismological Reference Earth Model in South China (SREM-SC) to provide a background velocity model for geological interpretations and fine-scale velocity inversion. The S-wave velocity model comes from combining models inverted by ambient noise tomography and surface wave tomography. The P-wave velocity model is obtained from converted S-wave velocity and joint inversion tomography. The density model is inferred from an empirical relationship with P-wave velocity. The Moho depth is obtained by a weighted averaging scheme of previously published receiver function results. The P-wave and S-wave velocity models have a grid interval of 0.5° in both latitude and longitude, and with a vertical sampling interval of 5 km down to the 60 km depth. This work provides the 3-D crust and uppermost mantle structures and a representative reference model beneath South China.</p

Association between trimester-specific gestational weight gain and childhood obesity at 5 years of age: results from Shanghai obesity cohort

Abstract Background It is still unclear if and at which trimester gestational weight gain is related to childhood adiposity. Thus we aimed to evaluate the association between trimester-specific gestational weight gain and body-fat compositions in Chinese children. Methods Maternal gestational weight were measured by trained nurses every 2 to 4 weeks from the first prenatal care, and body-fat compositions of 407 children from the Shanghai Obesity Cohort at 5 years of age were measured by nutritionist through bioelectrical impedance analysis. Overweight/obesity of children was defined according to the criteria of International Obesity Task Force. Logistic and linear regression models adjusted for potential confounders were conducted to evaluate the associations of gestational weight gains with childhood obesity and body-fat compositions. Two-sided P-value < 0.05 was considered statistically significant. Results Greater gestational weight gain in the 1st-trimester was significantly associated with a higher risk of childhood overweight/obesity [OR: 1.40 (95% CI: 1.06, 1.86)], fat mass index [β: 0.25 (95% CI: 0.12, 0.38)], body fat percentage [β: 1.04 (95% CI: 0.43, 1.65)], and waist-to-height ratio [β: 0.005 (95% CI: 0.002, 0.008)]. A positive but nonsignificant association was found between greater 3rd-trimester gestational weight gain and a higher risk of offspring overweight/obesity, and we speculated that the association between 2nd-trimester gestational weight gain and offspring overweight/obesity is the “U” type. Conclusions Weight gain in the first trimester gestation is positively correlated with the risk of childhood overweight/obesity and with body adiposity distributions of children at 5 years of age. Weight gain should be well controlled and monitored from early pregnancy