W=0 Pairing in (N,N)(N,N) Carbon Nanotubes away from Half Filling

We use the Hubbard Hamiltonian $H$ on the honeycomb lattice to represent the valence bands of carbon single-wall $(N,N)$ nanotubes. A detailed symmetry analysis shows that the model allows W=0 pairs which we define as two-body singlet eigenstates of $H$ with vanishing on-site repulsion. By means of a non-perturbative canonical transformation we calculate the effective interaction between the electrons of a W=0 pair added to the interacting ground state. We show that the dressed W=0 pair is a bound state for resonable parameter values away from half filling. Exact diagonalization results for the (1,1) nanotube confirm the expectations. For $(N,N)$ nanotubes of length $l$, the binding energy of the pair depends strongly on the filling and decreases towards a small but nonzero value as $l \to \infty$. We observe the existence of an optimal doping when the number of electrons per C atom is in the range 1.2$\div$1.3, and the binding energy is of the order of 0.1 $\div$ 1 meV.Comment: 16 pages, 6 figure

Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor.

BackgroundGastrointestinal stromal tumor (GIST) is the most common sarcoma and its treatment with imatinib has served as the paradigm for developing targeted anti-cancer therapies. Despite this success, imatinib-resistance has emerged as a major problem and therefore, the clinical efficacy of other drugs has been investigated. Unfortunately, most clinical trials have failed to identify efficacious drugs despite promising in vitro data and pathological responses in subcutaneous xenografts. We hypothesized that it was feasible to develop orthotopic patient-derived xenografts (PDXs) from resected GIST that could recapitulate the genetic heterogeneity and biology of the human disease.MethodsFresh tumor tissue from three patients with pathologically confirmed GISTs was obtained immediately following tumor resection. Tumor fragments (4.2-mm3) were surgically xenografted into the liver, gastric wall, renal capsule, and pancreas of immunodeficient mice. Tumor growth was serially assessed with ultrasonography (US) every 3-4 weeks. Tumors were also evaluated with positron emission tomography (PET). Animals were sacrificed when they became moribund or their tumors reached a threshold size of 2500-mm3. Tumors were subsequently passaged, as well as immunohistochemically and histologically analyzed.ResultsHerein, we describe the first model for generating orthotopic GIST PDXs. We have successfully xenografted three unique KIT-mutated tumors into a total of 25 mice with an overall success rate of 84% (21/25). We serially followed tumor growth with US to describe the natural history of PDX growth. Successful PDXs resulted in 12 primary xenografts in NOD-scid gamma or NOD-scid mice while subsequent successful passages resulted in 9 tumors. At a median of 7.9 weeks (range 2.9-33.1 weeks), tumor size averaged 473 ± 695-mm³ (median 199-mm3, range 12.6-2682.5-mm³) by US. Furthermore, tumor size on US within 14 days of death correlated with gross tumor size on necropsy. We also demonstrated that these tumors are FDG-avid on PET imaging, while immunohistochemically and histologically the PDXs resembled the primary tumors.ConclusionsWe report the first orthotopic model of human GIST using patient-derived tumor tissue. This novel, reproducible in vivo model of human GIST may enhance the study of GIST biology, biomarkers, personalized cancer treatments, and provide a preclinical platform to evaluate new therapeutic agents for GIST

Network-Oblivious Algorithms

A framework is proposed for the design and analysis of network-oblivious algorithms, namely algorithms that can run unchanged, yet efficiently, on a variety of machines characterized by different degrees of parallelism and communication capabilities. The framework prescribes that a network-oblivious algorithm be specified on a parallel model of computation where the only parameter is the problem\u2019s input size, and then evaluated on a model with two parameters, capturing parallelism granularity and communication latency. It is shown that for a wide class of network-oblivious algorithms, optimality in the latter model implies optimality in the decomposable bulk synchronous parallel model, which is known to effectively describe a wide and significant class of parallel platforms. The proposed framework can be regarded as an attempt to port the notion of obliviousness, well established in the context of cache hierarchies, to the realm of parallel computation. Its effectiveness is illustrated by providing optimal network-oblivious algorithms for a number of key problems. Some limitations of the oblivious approach are also discussed

Semantic Segmentation to Extract Coronary Arteries in Invasive Coronary Angiograms

Accurate semantic segmentation of each coronary artery using invasive coronary angiography (ICA) is important for stenosis assessment and coronary artery disease (CAD) diagnosis. In this paper, we propose a multi-step semantic segmentation algorithm based on analyzing arterial sements extraced from ICAs. The proposed algorithm firstly extracts the entire arterial binary mask (binary vascular tree) using a deep learning-based method. Then we extract the centerline of the binary vascular tree and separate it into different arterial segments. Finally, by extracting the underlyingarterial topology, position, and pixel features, we construct a powerful coronary artery segment classifier based on a support vector machine. Each arterial segment is classified into the left coronary artery (LCA), left anterior descending (LAD), and other types of arterial segments. The proposed method was tested on a dataset with 225 ICAs and achieved a mean accuracy of 70.33% for the multi-class artery classification and a mean intersection over union of 0.6868 for semantic segmentation of arteries. The experimental results show the effectiveness of the proposed algorithm, which provides impressive performance for analyzing the individual arteries in ICAs

Semantic Segmentation to Extract Coronary Arteries in Invasive Coronary Angiograms

Accurate semantic segmentation of each coronary artery using invasive coronary angiography (ICA) is important for stenosis assessment and coronary artery disease (CAD) diagnosis. In this paper, we propose a multi-step semantic segmentation algorithm based on analyzing arterial sements extraced from ICAs. The proposed algorithm firstly extracts the entire arterial binary mask (binary vascular tree) using a deep learning-based method. Then we extract the centerline of the binary vascular tree and separate it into different arterial segments. Finally, by extracting the underlyingarterial topology, position, and pixel features, we construct a powerful coronary artery segment classifier based on a support vector machine. Each arterial segment is classified into the left coronary artery (LCA), left anterior descending (LAD), and other types of arterial segments. The proposed method was tested on a dataset with 225 ICAs and achieved a mean accuracy of 70.33% for the multi-class artery classification and a mean intersection over union of 0.6868 for semantic segmentation of arteries. The experimental results show the effectiveness of the proposed algorithm, which provides impressive performance for analyzing the individual arteries in ICAs

High performance waveguide uni-travelling carrier photodiode grown by solid source molecular beam epitaxy

The first waveguide coupled phosphide-based UTC photodiodes grown by Solid Source Molecular Beam Epitaxy (SSMBE) are reported in this paper. Metal Organic Vapour Phase Epitaxy (MOVPE) and Gas Source MBE (GSMBE) have long been the predominant growth techniques for the production of high quality InGaAsP materials. The use of SSMBE overcomes the major issue associated with the unintentional diffusion of zinc in MOVPE and gives the benefit of the superior control provided by MBE growth techniques without the costs and the risks of handling toxic gases of GSMBE. The UTC epitaxial structure contains a 300 nm n-InP collection layer and a 300 nm n++-InGaAsP waveguide layer. UTC-PDs integrated with Coplanar Waveguides (CPW) exhibit 3 dB bandwidth greater than 65 GHz and output RF power of 1.1 dBm at 100 GHz. We also demonstrate accurate prediction of the absolute level of power radiated by our antenna integrated UTCs, between 200 GHz and 260 GHz, using 3d full-wave modelling and taking the UTC-to-antenna impedance match into account. Further, we present the first optical 3d full-wave modelling of waveguide UTCs, which provides a detailed insight into the coupling between a lensed optical fibre and the UTC chip.Comment: 19 pages, 24 figure

Quality of Life in Chronic Pancreatitis is Determined by Constant Pain, Disability/Unemployment, Current Smoking, and Associated Co-Morbidities

OBJECTIVES: Chronic pancreatitis (CP) has a profound independent effect on quality of life (QOL). Our aim was to identify factors that impact the QOL in CP patients. METHODS: We used data on 1,024 CP patients enrolled in the three NAPS2 studies. Information on demographics, risk factors, co-morbidities, disease phenotype, and treatments was obtained from responses to structured questionnaires. Physical and mental component summary (PCS and MCS, respectively) scores generated using responses to the Short Form-12 (SF-12) survey were used to assess QOL at enrollment. Multivariable linear regression models determined independent predictors of QOL. RESULTS: Mean PCS and MCS scores were 36.7+/-11.7 and 42.4+/-12.2, respectively. Significant (P \u3c 0.05) negative impact on PCS scores in multivariable analyses was noted owing to constant mild-moderate pain with episodes of severe pain or constant severe pain (10 points), constant mild-moderate pain (5.2), pain-related disability/unemployment (5.1), current smoking (2.9 points), and medical co-morbidities. Significant (P \u3c 0.05) negative impact on MCS scores was related to constant pain irrespective of severity (6.8-6.9 points), current smoking (3.9 points), and pain-related disability/unemployment (2.4 points). In women, disability/unemployment resulted in an additional 3.7 point reduction in MCS score. Final multivariable models explained 27% and 18% of the variance in PCS and MCS scores, respectively. Etiology, disease duration, pancreatic morphology, diabetes, exocrine insufficiency, and prior endotherapy/pancreatic surgery had no significant independent effect on QOL. CONCLUSIONS: Constant pain, pain-related disability/unemployment, current smoking, and concurrent co-morbidities significantly affect the QOL in CP. Further research is needed to identify factors impacting QOL not explained by our analyses